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      熱門詞:生物顯微鏡 水質分析儀 微波消解 熒光定量PCR 電化學工作站 生物安全柜

      現在位置首頁>技術資料首頁>行業動態>新品動態>FLEXCELL細胞機械牽拉儀器與美國B-Bridge細胞機械牽拉儀器對比,細胞力學設備對比,細胞加力設備對比

      FLEXCELL細胞機械牽拉儀器與美國B-Bridge細胞機械牽拉儀器對比,細胞力學設備對比,細胞加力設備對比

      世聯博研(北京)科技有限公司2014年2月10日 10:38 點擊:4555

       Comparison of the Flexcell® FX-5000T Tension System and STREX stretch device

      Flexcell® International Corporation products are broadly accepted and treated as the gold

      standard in the field of cytomechanics. Papers have been published in the highestranked journals’’ such as Nature’’ Nature Biotechnology’’ and the Journal of Biological Chemistry. Calibrated under the same tested system’’ customers can compare their data between two-dimensional and three-dimensional cultures’’ uniaxial and equibiaxial strain’’fluid shear stress’’ tension and compression.
       

       

      美國Flexcellint國際公司,成立于1987年,該公司專注于細胞力學培養產品的設計和制造。以提供獨特的體外細胞拉應力、壓應力和流體剪切應力加載刺激系統以及配套的培養板、硅膠膜載片等耗材聞名于世。

      Flexcell的細胞組織體外機械力加載裝置的細胞力學加載方法和能模擬生命體內細胞組織生長生物力環境、實現體外分離和建立合適的加載膜型公認國際領先,詳見應用案例文獻庫

      Flexcell細胞組織力學培養系統不僅能對各種2D、3D細胞組織提供拉應力、壓應力、切應力刺激加載,而且還可以提供拉應力和切應力混合力同時加載;不僅能對細胞組織進行機械力加載刺激,而且還能三維培養、人工生物組織構建、動力模擬;不僅能單軸向牽張拉伸,而且還可以雙軸向牽張拉伸。

      Flexcell獨具的StageFlexer拉應力顯微設備、StagePresser壓應力顯微設備、Flex Flow切應力顯微設備;這些顯微設備可在加力培養的同時實時觀察研究細胞組織反應變化;獨具的flexstop隔離閥能使同一塊培養板里的細胞組織一部分受力,一部分不受力,方便進行對比實驗

      這些系統智能、精準誘導來自各種細胞、組織在拉力、壓力和流體切應力作用下發生的生化生理變化,專業、細膩的闡釋了體外細胞、組織機械力刺激加載、力學信號感受和響應機制。對研究細胞的形態結構及功能,細胞的生長、發育、成熟、增殖、衰老、凋亡、死亡及癌變以及通路表達,細胞信號傳導及基因表達的調控,細胞的分化及其調控機理具有重要意義。

      典型應用科室:

      口腔 顳下頜關節滑膜細胞、人牙周膜細胞、口腔上皮細胞、口腔鱗癌KB細胞等
      骨: 骨骼細胞、肌腱細胞、韌帶細胞、軟骨細胞和骨細胞、骨髓間充質干細胞,軟骨組織、椎間盤骨組織、肌腱組織、韌帶組織等
      肺呼吸 肺細胞、肺上皮細胞、肺動脈內皮細胞、人肺微血管內皮細胞
      眼科視覺神經 眼上皮細胞、眼小梁組織細胞、視網膜神經細胞
      心血管/高血壓: 心肌細胞、血細胞、心血管平滑肌細胞、血管內皮細胞
      生殖 腎膀胱細胞、平滑肌細胞/尿路上皮及尿路上皮細胞、腎小管上皮細胞
      消化 腸上皮細胞、 胃上皮細胞、胃血管內皮細胞
      皮膚 皮膚細胞、皮膚成纖維細胞
      Flexcell模塊化的拉應力、壓應力、切應力、三維培養模塊,可任意組合統一主機多功能平臺

      1、FX-5000T細胞牽張拉伸應力加載系統(Flexcell FX5000 Tension system)


      1)該系統對二維、三維細胞和組織提供軸向和圓周應力加載; 
      2)基于柔性膜基底變形、受力均勻; 
      3)可實時觀察細胞、組織在應力作用下的反應; 
      4)獨具的flexstop隔離閥可使同一塊培養板力的一部分培養孔的細胞受力,一部分培養孔的細胞不受力,方便對比實驗; 
      5)與壓力傳導儀整合,同時兼備多通道細胞壓力加載功能; 
      6)與Flex Flow平行板流室配套,可在牽拉細胞的同時施加流體切應力; 
      7)多達4通道,可4個不同程序同時運行,進行多個不同拉伸形變率對比實驗; 
      8)同一程序中可以運行多種頻率,多種振幅和多種波形; 
      9)更好地控制在超低或超高應力下的波形; 
      10)多種波形種類:靜態波形、正旋波形、心動波形、三角波形、矩形以及各種特制波形; 
      11)電腦系統對牽張拉伸力加載周期、大小、頻率、持續時間精確智能調控 
      12)加載分析各種細胞在牽張拉應力刺激下的生物化學反應 
      13)伸展度:0-33% 
      14)牽拉頻率:0.01-5Hz

      2、FX-5000C細胞壓力加載系統(flexcell FX5000 Compression system)——提供樣機體驗

      1)該系統對各種組織、三維細胞培養物提供周期性或靜態的壓力加載;
      2)基于柔性膜基底變形、受力均勻;
      3)可實時觀察細胞、組織在壓力作用下的反應;
      4)可有選擇性地封阻對細胞的應力加載;

      5)同時兼備多通道細胞牽拉力加載功能;
      6)多達4通道,可4個不同程序同時運行,進行多個不同壓力形變率對比實驗;
      7)同一程序中可以運行多種頻率(0.01- 5 Hz),多種振幅和多種波形;
      8)更好地控制在超低或超高應力下的波形;
      9)多種波形種類:靜態波形、正旋波形、心動波形、三角波形、矩形以及各種特制波形;
      10)電腦系統對壓力加載周期、大小、頻率、持續時間精確智能調控
      11)檢測各種組織和細胞在壓力作用下的生物化學反應 
      12)壓力范圍:0.1 - 14磅

       


      3、TissueTrain可拉伸組織工程三維細胞培養系統(Flexcell TissueTrain System)——提供樣機體驗

      FLEXCELL Tissue Train® 是個獨立的全自動細胞組織三維培養、組織構建計算機智能控制的生物反應器系統,它允許研究者創建三維基質凝膠支架,
      在基質里細胞培養、構建生物組織,可為三維細胞、組織提供雙軸向應力和單軸向應力,FLEXCELL Tissue Train®
      是當今科研界最先進的可拉伸刺激三維細胞培養、生物組織構建系統系統。
      系統功能亮點:
      • 三維細胞牽張應力加載刺激:對生長在三維狀態下的細胞進行靜態的或者周期性的拉應力刺激
        通過Flexcell應力加載系統和弧矩形加載平臺對生長在三維環境下的細胞進行單軸向
        或者雙軸向的靜態或者周期性的應力加載刺激培養
      • 三維細胞培養:使用三維組織培養模具和三維細胞培養板可以進行三維細胞培養在凝膠支架里全自動三維培養
        三維組織培養模具和三維細胞培養板類型豐富:
        1)三維組織培養模具有三維線形培養加載基站模具和三維梯形培養加載基站模具
        2)具有氨基酸包被表面、膠原(I型或IV)包被表面、彈性蛋白包被表面、ProNectin(RGD)包被表面、層粘連蛋白(YIGSR)包被表面的三維培養板。
        科研者根據自己的細胞,有針對性的選擇適合包被表面三維培養板
        3)具有可牽拉雙軸向和單軸向拉力刺激加載三維組織培養板。
      • 大體積三維生物人工組織培養構建:可構建長度達35mm的生物人工組織
      • 動力模擬實驗:可建立特制的各種模擬實驗:心率模擬實驗、步行模擬實驗、跑動模擬實驗和其他動力模擬實驗
      • 本系統技術先進性:
        1)安全快速的擴增細胞
        2)在細胞特異性基質(圓盤形陶瓷載體培養片) 中進行三維的細胞高密度培養
        3)擴增并獲得可用于治療的有活性的原代細胞
        4)在控制分化狀態的條件下擴增干細胞
        5)向植入的一代細胞提供植入支架
        6)長期培養分泌細胞
        7)高效生產重組蛋白和疫苗
        8)生產優質的糖蛋白
        9)三維培養與機械力刺激有機結合
        10)三維凝膠壓實自動測量與面積自動計算
      • 可用于多個領域,如研究、生物制藥加工;也可為細胞和組織培養工作提供解決方案:
        1)可用于干細胞和胚體擴增及定向分化
        2)可用于細胞和組織治療的細胞制備
        3)可用于克隆細胞,為器官移植做準備(例如hip stem, heart valve, graft)
        4)可用于制備天然的生物制品(例如糖蛋白、病毒、病毒樣顆粒)
      • 觀察細胞應力下實時反映:使用Flexcell獨有的Flexcell StageFlexer Jr.顯微附屬設備,可在加力刺激的同時實時觀察細胞在三維狀態下牽拉刺激的反應
      • 多種基質蛋白包被的尼龍網錨可以加強細胞與網錨的結合


      4、STR-4000細胞流體切應力系統(Flexcell Fluid Shear Stress Device)——提供樣機體驗

      4.1、六通道流體切應力加載分析設備—Streamer剪切力設備


      • 為細胞提供各種形式的流體切應力:穩流式切應力、脈沖式切應力或者往返式切應力。
      • 在經過特殊基質蛋白包被的25x 75x 1.0mm細胞培養載片上培養細胞。
      • 多達6通道,每個通道放不同載片,可培養不同的細胞
      • 計算機控制的蠕動泵可以調節切應力大小從0-35 dynes/cm2
      • 通過Osci-Flow液體控制儀提供往返式或脈沖式流體切應力。
      • 檢測細胞在液流作用下的排列反應。
      • 設備易拆卸并可高溫消毒。
      • 可以在經過特殊包被的6個細胞培養載片上同時培養細胞。
      • 提供兩個液流脈沖阻尼器。 
        Streamer System產品包括: 
        1)Streamer設備; 
        2) DELL筆記本式計算機; 
        3)快拆接頭及膠管; 
        4)蠕動泵; 
        5)StreamSoft軟件; 
        6)2個液流脈沖阻尼器; 
        7)12個細胞培養載片(Culture Slip)

        4.2、HiQ Flowmate納升和微微液流控制雙注射系統

        三維細胞力學加載儀,體外細胞牽張壓縮應力,體外細胞機械加力裝置,體外細胞牽張刺激裝置,細胞牽張應力加

      • 雙注射泵可以在微升,納升和微微升水平上控制液流.雙注射泵,獨立的液流控制系統。
      • 傳送精確,穩定的流速
      • 可控流速范圍1.2pL/ min-260.6ml/min
      • 提供不同流速模型:穩定型,脈沖型,連續型,截流型和震蕩型;
      • 可進行循環,連續的液流控制;同時運行不同的流速模型;
      • 內置閥門控制液流模式;
      • 機載計算器用于流量、流時、流速、剪切力的計算;
      • 高分辨率、觸屏控制。
      • 用戶友好的圖標驅動程序;
      • 便于泵和芯片對接的生物芯片支架;根據現有流速有三種不同的機型;

        多種應用程序:

      • 液體稀釋,配給及注射器;
      • 動物實驗中的藥物注射和體液抽??;
      • 施加液流剪切力;
      • 微流體和納流體實驗;
      • 混合、分流液體;
      • 震蕩型液流的控制需要iHIQ Flowmate二級閥門配件

         

         

        4.3 Osci-Flow切應力模式控制器——完美的液流控制模式

         

        三維細胞力學加載儀,體外細胞牽張壓縮應力,體外細胞機械加力裝置,體外細胞牽張刺激裝置,細胞牽張應力加

      • 通過計算機控制提供可調控的,往返式的或者脈沖式的流體切應力。
      • 和Streamer及FlexFlow shear stress設備一起使用。
      • 維持泵的流速不,最大限度的降低改變泵的轉速引起的流液的延反應遲。
      • 可以在瞬間內改變流體流動方向。
      • 兼容其它公司生產的灌流系統。
      • 兼容各種類型MasterFlexL/S系列或者相應的膠管。
      • 通過PC板卡可以和絕大多數便攜式計算機連接使用。
      • Osci-Flow裝置DAQ Card DIO-24說明書和NI-DAQ軟件
      • 連接Osci-Flow和板卡的纜線;
      • DELL電腦需單獨購買
      • 膠管和快拆接頭;StreamSoft軟件;

      5、Flexflow平行板流室系統提供流體切應力同時抻拉細胞

      FlexcellFlexFlow顯微切應力加載設備(SHEAR Stress device)
      • 可以在提供流體切應力的同時抻拉細胞,測試血管和結綈組織細胞對液體流動的實時反應。
      • 為培育在StageFlexer硅膠模表面或者基質蛋白包被的細胞培養片上的細胞提供切應力。
      • 使用FX-5000T應力加載系統抻拉細胞,并且可以在實驗前,實驗中或者實驗后提供切應力。
      • 計算機控制蠕動泵,調節切應力大小,從0-35 dynes/cm2
      • 使用標準正立式顯微鏡實時觀察細胞在切應力下的反應。
      • 檢測細胞在流體作用下的排列反應。
      • 檢測在液體切應力下各種激活劑/抑制劑對細胞反應的影響。使用熒光團例如FURA-2檢測細胞內[Ca2+]ic或者其它離子對切應力反應。 
        FlexFlow系統包括:
      • FlexFlow裝置;StreamSoft軟件
      • FlexFlow快拆接頭、膠管、FlexFlow 旁路連接器
      • MASTERFLEX L/S型號7550-10蠕動泵及配套線纜、連接管
      • 2個穩流器;硅潤滑劑
      • FX -5000 張力系統適配器
      • 顯微鏡適應性FlexFlow底座
      • 快速鏈接細胞培養基瓶;一個快速鏈接真空瓶
      • 三個沒滅菌和六個滅菌膠原蛋白涂層薄培養載片
      • 三個沒滅菌和六個滅菌膠原涂層StageFlexer膜
      • 配件包

        保證細胞在不同水平恒流或生理剪切力作用下仍保持黏附,在研究中得到了廣泛應用。用蠕動泵(peristaltic pump)或注射泵(syringe pump)提供瞬態剪切力使平行板流室的入流管和出流管之間產生壓差,使流室內細胞受到均勻,震蕩或脈動剪切力的作用。

        平臺總結:

        • 力類型:具有細胞組織力學所要求的所有類型:牽張拉伸力、壓力、流體切應力(各種形式的流體切應力:穩流式切應力,脈沖式切應力或者往返式切應力)
        • 軸向:不但具有雙軸向拉伸力加載,還具備單軸向加力功能
        • 培養物類型:能對各種2D和3D細胞級別或組織級別培養加載刺激;可以構建長達35mm的人工生物組織
        • 壓應力和拉應力波形類型波形豐富,既能提供模擬加載的靜態波形、正旋波形、心動波形、三角波形、矩形波形和各種自定義波形
        • 平臺擴充性:在同一電腦主機上,具備拉應力、壓應力、流體切應力模塊任意組合
        • 系統壓力可擴展性:具有模塊化、多通道加載功能,可進行不同壓縮形變對比實驗室
        • 系統牽張拉伸力可擴展性:具有模塊化、多通道加載功能,可進行不同牽張拉伸形變對比實驗室
        • 系統切應力可擴展性:流體切應力模塊和拉應力可同時混合加載刺激
        • 產品成熟度:國外內有大量應用文獻案例(詳見應用案例文獻庫),國內至少有10家成功使用案例

         

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        目錄

        Flexcell FX-5000細胞牽張拉伸培養系統應用文獻

        膀胱(Bladder)細胞牽張拉伸應力應用文獻 
            膀胱平滑肌細胞(Bladder smooth muscle cells)細胞牽張拉伸應力應用文獻 
            尿路上皮及尿路上皮細胞(Urothelial & uroepithelial cells) 細胞牽張拉伸應力應用文獻


        骨(Bone)細胞牽張拉伸應力應用文獻

        心臟血管(Cardio vasculature)細胞牽張拉伸應力應用文獻 
            心肌細胞和成纖維細胞(Cardiomyocytes and fibroblasts)牽張拉伸應力應用文獻 
            心血管內皮細胞(Cardiovascular endothelial cells)牽張拉伸應力應用文獻 
            心血管平滑肌細胞(Cardiovascular smooth muscle cells)牽張拉伸應力應用文獻 
            其他心血管細胞(Other cardiovascular cells)細胞牽張拉伸應力應用文獻 
        軟骨(Cartilage)細胞牽張拉伸應力應用文獻 
            關節軟骨細胞(Articular chondrocytes)細胞牽張拉伸應力應用文獻 
            其他的軟骨細胞(Other cartilage cells)細胞牽張拉伸應力應用文獻 
        皮膚成纖維細胞(Dermal Fibroblasts)細胞牽張拉伸應力應用文獻 
            內皮細胞(Endothelial cells)細胞牽張拉伸應力應用文獻 
            心血管內皮細胞(Cardiovascular endothelial cells)細胞牽張拉伸應力應用文獻 
            肺動脈內皮細胞(Pulmonary endothelial cells)細胞牽張拉伸應力應用文獻 
            其他的內皮細胞(Other endothelial cells)細胞牽張拉伸應力應用文獻 
        上皮細胞(Epithelial Cells)細胞牽張拉伸應力應用文獻 
            Caco-2腸上皮細胞(Caco-2 intenstinal epithelial cells)細胞牽張拉伸應力應用文獻 
            眼睛的上皮細胞(Eye epithelial cells)細胞牽張拉伸應力應用文獻 
            胃上皮細胞(Gastric epithelial cells)細胞牽張拉伸應力應用文獻 
            肺上皮細胞(Pulmonary epithelial cells)細胞牽張拉伸應力應用文獻 
            腎小管上皮細胞(Renal epithelial cells)細胞牽張拉伸應力應用文獻 
            其他上皮細胞(Other epithelial cells)細胞牽張拉伸應力應用文獻 
        眼睛(Eye)細胞牽張拉伸應力應用文獻 
            眼睛的上皮細胞(Eye epithelial cells)細胞牽張拉伸應力應用文獻 
            眼小梁細胞(Trabecular meshwork cells)細胞牽張拉伸應力應用文獻 
        牙齦成纖維細胞(Gingival Fibroblasts)細胞牽張拉伸應力應用文獻 
        椎間盤(Intervertebral Disc)細胞牽張拉伸應力應用文獻 
        角質形成細胞(Keratinocytes)細胞牽張拉伸應力應用文獻 
        腎(Kidney)細胞牽張拉伸應力應用文獻 
            腎小球膜細胞(Mesangial cells)細胞牽張拉伸應力應用文獻 
            腎小管上皮細胞(Renal epithelial cells)細胞牽張拉伸應力應用文獻 
        韌帶(Ligament)細胞牽張拉伸應力應用文獻 
            牙周膜(Periodontal ligament)細胞牽張拉伸應力應用文獻 
            膝關節韌帶(Knee ligaments)細胞牽張拉伸應力應用文獻 
            其他韌帶細胞(Other ligament cells)牽張拉伸應力應用文獻 
        肝臟(Liver)細胞牽張拉伸應力應用文獻 
        肺(Lung)細胞牽張拉伸應力應用文獻 
            肺泡巨噬細胞(Alveolar macrophages)牽張拉伸應力應用文獻 
            肺成纖維細胞(Lung fibroblasts)牽張拉伸應力應用文獻 
            間皮細胞(Mesothelial cells)牽張拉伸應力應用文獻 
            肺動脈內皮細胞(Pulmonary endothelial cells)牽張拉伸應力應用文獻 
            肺上皮細胞(Pulmonary epithelial cells)牽張拉伸應力應用文獻 
            肺動脈平滑肌細胞(Pulmonary smooth muscle cells)牽張拉伸應力應用文獻 
            其他肺部細胞(Other pulmonary cells)牽張拉伸應力應用文獻 
        半月板(Meniscus)細胞牽張拉伸應力應用文獻 
        神經元,星形膠質細胞,及腦(Neurons, Astrocytes, & Brain)細胞牽張拉伸應力應用文獻 
        骨骼肌(Skeletal Muscle)細胞牽張拉伸應力應用文獻 
        平滑肌細胞(Smooth Muscle Cells)細胞牽張拉伸應力應用文獻 
             膀胱平滑肌細胞(Bladder smooth muscle cells)牽張拉伸應力應用文獻 
            心血管平滑肌細胞(Cardiovascular smooth muscle cells)牽張拉伸應力應用文獻 
            肺動脈平滑肌細胞(Pulmonary smooth muscle cells)牽張拉伸應力應用文獻 
            子宮/子宮肌層平滑肌細胞(Uterine/myometrial smooth muscle cells)牽張拉伸應力應用文獻 
            其他平滑肌細胞(Other smooth muscle cells)牽張拉伸應力應用文獻 
        基質干細胞/內皮祖細胞/干細胞(Stromal/ Progenitor/ Stem Cells)牽張拉伸應力應用文獻 
        滑膜(Synovial)細胞牽張拉伸應力應用文獻 
        肌腱(Tendon)細胞牽張拉伸應力應用文獻 
        子宮(Uterine)細胞牽張拉伸應力應用文獻 
            子宮/子宮肌層平滑肌細胞(Uterine/myometrial smooth muscle cells)牽張拉伸應力應用文獻 
        其他類型的細胞(Other Cell Types)牽張拉伸應力應用文獻 
        點評與評論文章(Reviews & Commentaries)細胞牽張拉伸應力應用文獻 
        UNIFLEX®和單軸拉伸(UNIFLEX®AND UNIAXIAL TENSION)細胞牽張拉伸應力應用文獻 

        Tissue Train®Flexcell FX-5000TT組織工程三維牽張拉伸培養系統應用文獻 
        張力系統應變分布(TENSION SYSTEM STRAIN PROFILES)細胞牽張拉伸應力應用文獻 
        張力系統中的應用(APPLICATION OF TENSION SYSTEM)細胞牽張拉伸應力應用文獻 

        BIOPRESS和Flexcell FX-5000C細胞組織三維培養物壓應力加載培養系統(BIOPRESS AND COMPRESSION SYSTEM)應用文獻 
        細胞壓應力培養系統中的應用(APPLICATION OF COMPRESSION SYSTEM)細胞壓縮系統中的應用文獻 

        FLEXFLOW Stream®流體剪切力系統(FLEXFLOW AND STREAMER®FLUID SHEAR STRESS SYSTEMS)應用文獻 
        培養板和載玻片中的應用(APPLICATION OF CULTURE PLATES AND SLIDES)細胞牽張拉伸應力應用文獻 
        客戶改性單位(CUSTOMER-MODIFIED UNITS)細胞牽張拉伸應力應用 
        美國專利(U.S. PATENTS)細胞牽張拉伸應力應用 
        國際專利(INTERNATIONAL PATENTS)細胞牽張拉伸應力應用 

        TENSION SYSTEM
        (categorized by system, tissue, and/or cell type)

        膀胱(Bladder)細胞牽張拉伸應力應用文獻

        膀胱平滑肌細胞(Bladder smooth muscle cells)牽張拉伸應力應用文獻

        1. Adam RM, Eaton SH, Estrada C, Nimgaonkar A, Shih SC, Smith LE, Kohane IS, Bagli D, Freeman MR. Mechanical stretch is a highly selective regulator of gene expression in human bladder smooth muscle cells. Physiol Genomics 20(1):36-44, 2004. 
        2. Adam RM, Roth JA, Cheng HL, Rice DC, Khoury J, Bauer SB, Peters CA, Freeman MR. Signaling through PI3K/Akt mediates stretch and PDGF-BB-dependent DNA synthesis in bladder smooth muscle cells. J Urol 169(6):2388-2393, 2003. 
        3. Aitken KJ, Block G, Lorenzo A, Herz D, Sabha N, Dessouki O, Fung F, Szybowska M, Craig L, Bagli DJ.Mechanotransduction of extracellular signal-regulated kinases 1 and 2 mitogen-activated protein kinase activity in smooth muscle is dependent on the extracellular matrix and regulated by matrix metalloproteinases. Am J Pathol 169(2):459-470, 2006. 
        4. Aitken KJ, Tolg C, Panchal T, Leslie B, Yu J, Elkelini M, Sabha N, Tse DJ, Lorenzo AJ, Hassouna M, Bgli DJ. Mammalian target of rapamycin (mTOR) induces proliferation and de-differentiation responses to three coordinate pathophysiologic stimuli (mechanical strain, hypoxia, and extracellular matrix remodeling) in rat bladder smooth muscle. Am J Pathol 176(1):304-319, 2010. Epub 2009 Dec 17. 
        5. Chaqour B, Yang R, Sha Q. Mechanical stretch modulates the promoter activity of the profibrotic factor CCN2 through increased actin polymerization and NF-κB activation. J Biol Chem 281(29):20608-20622, 2006. 
        6. Estrada CR, Adam RM, Eaton SH, Bgli DJ, Freeman MR. Inhibition of EGFR signaling abrogates smooth muscle proliferation resulting from sustained distension of the urinary bladder. Lab Invest 86(12):1293-1302, 2006. 
        7. Galvin DJ, Watson RW, Gillespie JI, Brady H, Fitzpatrick JM. Mechanical stretch regulates cell survival in human bladder smooth muscle cells in vitro. Am J Physiol Renal Physiol 283(6):F1192-F1199, 2002. 
        8. Halachmi S, Aitken KJ, Szybowska M, Sabha N, Dessouki S, Lorenzo A, Tse D, Bagli DJ. Role of signal transducer and activator of transcription 3 (STAT3) in stretch injury to bladder smooth muscle cells. Cell Tissue Res 326(1):149-158, 2006. 
        9. Hubschmid U, Leong-Morgenthaler PM, Basset-Dardare A, Ruault S, Frey P. In vitro growth of human urinary tract smooth muscle cells on laminin and collagen type I-coated membranes under static and dynamic conditions. Tissue Engineering 11(1-2):161-171, 2005. 
        10. Kushida N, Kabuyama Y, Yamaguchi O, Homma Y. Essential role for extracellular Ca2+ in JNK activation by mechanical stretch in bladder smooth muscle cells. Am J Physiol Cell Physiol 281(4):C1165-C1172, 2001. 
        11. Nguyen HT, Adam RM, Bride SH, Park JM, Peters CA, Freeman MR. Cyclic stretch activates p38 SAPK2-, ErbB2-, and AT1-dependent signaling in bladder smooth muscle cells. Am J Physiol Cell Physiol 279(4):C1155-C1167, 2000. 
        12. Orsola A, Adam RM, Peters CA, Freeman MR. The decision to undergo DNA or protein synthesis is determined by the degree of mechanical deformation in human bladder muscle cells. Urology 59(5):779-783, 2002. 
        13. Orsola A, Estrada CR, Nguyen HT, Retik AB, Freeman MR, Peters CA, Adam RM. Growth and stretch response of human exstrophy bladder smooth muscle cells: molecular evidence of normal intrinsic function. BJU Int 95(1):144-148, 2005. 
        14. Park JM, Adam RM, Peters CA, Guthrie PD, Sun Z, Klagsbrun M, Freeman MR. AP-1 mediates stretch-induced expression of HB-EGF in bladder smooth muscle cells. Am J Physiol Cell Physiol 277:C294-C301, 1999. 
        15. Park JM, Borer JG, Freeman MR, Peters CA. Stretch activates heparin-binding EGF-like growth factor expression in bladder smooth muscle cells. Am J Physiol Cell Physiol 275:C1247-C1254, 1998. 
        16. Park JM, Yang T, Arend LJ, Schnermann JB, Peters CA, Freeman MR, Briggs JP. Obstruction stimulates COX-2 expression in bladder smooth muscle cells via increased mechanical stretch. Am J Physiol Renal Physiol 276:F129-F136, 1999. 
        17. Persson K, Sando JJ, Tuttle JB, Steers WD. Protein kinase C in cyclic stretch-induced nerve growth factor production by urinary tract smooth muscle cells. Am J Physiol Cell Physiol 269:C1018-C1024, 1995. 
        18. Steers WD, Broder SR, Persson K, Bruns DE, Ferguson JE 2nd, Bruns ME, Tuttle JB. Mechanical stretch increases secretion of parathyroid hormone-related protein by cultured bladder smooth muscle cells. J Urol 160(3 Pt 1):908-912, 1998. 
        19. Upadhyay J, Aitken KJ, Damdar C, Bolduc S, Bagli DJ. Integrins expressed with bladder extracellular matrix after stretch injury in vivo mediate bladder smooth muscle cell growth in vitro. J Urol 169(2):750-755, 2003. 
        20. Yang R, Amir J, Liu H, Chaqour B. Mechanical strain activates a program of genes functionally involved in paracrine signaling of angiogenesis. Physiol Genomics 36(1):1-14, 2008. Epub 2008 Oct 14. 
        21. Yu G, Bo S, Xiyu J, Enqing X. Effect of bladder outlet obstruction on detrusor smooth muscle cell: an in vitro study. Journal of Surgical Research 114(2):202-209, 2003. 
        22. Zhou D, Herrick DJ, Rosenbloom J, Chaqour B. Cyr61 mediates the expression of VEGF, αv-integrin, and α-actin genes through cytoskeletally based mechanotransduction mechanisms in bladder smooth muscle cells. J Appl Physiol 98(6):2344-2354, 2005.

        尿路上皮及尿路上皮細胞(Urothelial & uroepithelial cells) 牽張拉伸應力應用文獻

        23. Jerde TJ, Mellon WS, Bjorling DE, Nakada SY. Evaluation of urothelial stretch-induced cyclooxygenase-2 expression in novel human cell culture and porcine in vivo ureteral obstruction models. J Pharmacol Exp Ther 317(3):965-972, 2006. 
        24. Jerde TJ, Mellon WS, Bjorling DE, Checura CM, Owusu-Ofori K, Parrish JJ, Nakada SY. Stretch induction of cyclooxygenase-2 expression in human urothelial cells is calcium- and protein kinase C zeta-dependent. Mol Pharmacol 73(1):18-26, 2008. Erratum in: Mol Pharmacol 74(2):539, 2008. 
        25. Sun Y, Chai TC. Effects of dimethyl sulphoxide and heparin on stretch-activated ATP release by bladder urothelial cells from patients with interstitial cystitis. BJU Int 90(4):381-385, 2002. 
        26. Sun Y, Chai TC. Up-regulation of P2X3 receptor during stretch of bladder urothelial cells from patients with interstitial cystitis. J Urol 171(1):448-452, 2004. 
        27. Sun Y, Keay S, De Deyne PG, Chai TC. Augmented stretch activated adenosine triphosphate release from bladder uroepithelial cells in patients with interstitial cystitis. Journal of Urology 166(5):1951-1956, 2001.
        28. Sun Y, Keay S, DeDeyne P, Chai T. Stretch-activated release of adenosine triphosphate by bladder uroepithelia is augmented in interstitial cystitis [abstract]. Urology 57(6 Suppl 1):131, 2001. 
        29. Sun Y, MaLossi J, Jacobs SC, Chai TC. Effect of doxazosin on stretch-activated adenosine triphosphate release in bladder urothelial cells from patients with benign prostatic hyperplasia. Urology 60(2):351-356, 2002.

        骨(Bone)(細胞)牽張拉伸應力應用文獻

        1. Aguirre JI, Plotkin LI, Gortazar AR, Millan MM, O’Brien CA, Manolagas SC, Bellido T. A novel ligand-independent function of the estrogen receptor is essential for osteocyte and osteoblast mechanotransduction. J Biol Chem 282(35):25501–25508, 2007.

        2. Bellido T, Plotkin LI. Detection of apoptosis of bone cells in vitro. Methods in

        Molecular Biology, Vol. 455: Osteoporosis: Methods and Protocols. Edited by Westendorf JJ. Humana Press: Totowa, 51-75, 2008. 
        3. Bhatt KA, Chang EI, Warren SM, Lin SE, Bastidas N, Ghali S, Thibboneir A, Capla JM, McCarthy JG, Gurtner GC. Uniaxial mechanical strain: an in vitro correlate to distraction osteogenesis. J Surg Res 143(2):329-36, 2007. Epub 2007 Oct 22. 
        4. Boutahar N, Guignandon A, Vico L, Lafage-Proust MH. Mechanical strain on osteoblasts activates autophosphorylation of focal adhesion kinase and proline-rich tyrosine kinase 2 tyrosine sites involved in ERK activation. J Biol Chem 279(29):30588-30599, 2004. 
        5. Buckley MJ, Banes AJ, Jordan RD. The effects of mechanical strain on osteoblasts in vitro. J Oral Maxillofac Surg 48(3):276-282, 1990. 
        6. Buckley MJ, Banes AJ, Levin LG, Sumpio BE, Sato M, Jordan R, Gilbert J, Link GW, Tran Son Tay R. Osteoblasts increase their rate of division and align in response to cyclic, mechanical tension in vitro. Bone Miner 4(3):225-236, 1988. 
        7. Calvalho RS, Bumann A, Schwarzer C, Scott E, Yen EH. A molecular mechanism of integrin regulation from bone cells stimulated by orthodontic forces. Eur J Orthod 18(3):227-235, 1996. 
        8. Carvalho RS, Bumann A, Schwarzer C, Scott E, Yen HK. A molecular mechanism of integrin regulation from bone cells stimulated by orthodontic forces. The European Journal of Orthodontics 18(1):227-235, 1996. 
        9. Carvalho RS, Scott JE, Suga DM, Yen EH. Stimulation of signal transduction pathways in osteoblasts by mechanical strain potentiated by parathyroid hormone. J Bone Miner Res 9(7):999-1011, 1994. 
        10. Carvalho RS, Scott JE, Yen EH. The effects of mechanical stimulation on the distribution of β1 integrin and expression of β1-integrin mRNA in TE-85 human osteosarcoma cells. Arch Oral Biol 40(3):257-264, 1995. 
        11. Case N, Ma M, Sen B, Xie Z, Gross TS, Rubin J. β-catenin levels influence rapid mechanical responses in osteoblasts. J Biol Chem 283(43):29196-29205, 2008. Epub 2008 Aug 22. 
        12. Chen X, Macica CM, Ng KW, Broadus AE. Stretch-induced PTH-related protein gene expression in osteoblasts. J Bone Miner Res20(8):1454-61, 2005. 
        13. Cillo JE Jr, Gassner R, Koepsel RR, Buckley MJ. Growth factor and cytokine gene expression in mechanically strained human osteoblast-like cells: implications for distraction osteogenesis. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 90(2):147-154, 2000. 
        14. Duncan RL, Hruska KA. Chronic, intermittent loading alters mechanosensitive channel characteristics in osteoblast-like cells. Am J Physiol Renal Physiol 267:F909-F916, 1994. 
        15. Fan X, Rahnert JA, Murphy TC, Nanes MS, Greenfield EM, Rubin J. Response to mechanical strain in an immortalized pre-osteoblast cell is dependent on ERK1/2. J Cell Physiol 207(2):454-460, 2006. 
        16. Faure C, Linossier MT, Malaval L, Lafage-Proust MH, Peyroche S, Vico L, Guignandon A. Mechanical signals modulated vascular endothelial growth factor-A (VEGF-A) alternative splicing in osteoblastic cells through actin polymerisation. Bone 42(6):1092-1101, 2008. Epub 2008 Feb 29. 
        17. Faure C, Vico L, Tracqui P, Laroche N, Vanden-Bossche A, Linossier MT, Rattner A, Guignandon A. Functionalization of matrices by cyclically stretched osteoblasts through matrix targeting of VEGF. Biomaterials 31(25):6477-6484, 2010. Epub 2010 Jun 11. 
        18. Geng WD, Boskovic G, Fultz ME, Li C, Niles RM, Ohno S, Wright GL. Regulation of expression and activity of four PKC isozymes in confluent and mechanically stimulated UMR-108 osteoblastic cells. J Cell Physiol 189(2):216-228, 2001. 
        19. Granet C, Boutahar N, Vico L, Alexandre C, Lafage-Proust MH. MAPK and SRC-kinases control EGR-1 and NF-κB inductions by changes in mechanical environment in osteoblasts. Biochem Biophys Res Commun 284(3):622-631, 2001. 
        20. Granet C, Vico AG, Alexandre C, Lafage-Proust MH. MAP and src kinases control the induction of AP-1 members in response to changes in mechanical environment in osteoblastic cells. Cellular Signaling 14(8):679-688, 2002. 
        21. Grimston SK, Screen J, Haskell JH, Chung DJ, Brodt MD, Silva MJ, Civitelli R. Role of connexin43 in osteoblast response to physical load. Ann N Y Acad Sci 1068:214-224, 2006. 
        22. Guignandon A, Akhouayri O, Usson Y, Rattner A, Laroche N, Lafage-Proust MH, Alexandre C, Vico L. Focal contact clustering in osteoblastic cells under mechanical stresses: microgravity and cyclic deformation. Cell Commun Adhes 10(2):69-83, 2003. 
        23. Guignandon A, Boutahar N, Rattner A, Vico L, Lafage-Proust MH. Cyclic strain promotes shuttling of PYK2/Hic-5 complex from focal contacts in osteoblast-like cells. Biochem Biophys Res Commun 343(2):407-14, 2006. 
        24. Hara F, Fukuda K, Asada S, Matsukawa M, Hamanishi C. Cyclic tensile stretch inhibition of nitric oxide release from osteoblast-like cells is both G protein and actin-dependent. Journal of Orthopaedic Research 19(1):126-131, 2001. 
        25. Hara F, Fukuda K, Ueno M, Hamanishi C, Tanaka S. Pertussis toxin-sensitive G proteins as mediators of stretch-induced decrease in nitric-oxide release of osteoblast-like cells. J Orthop Res 17(4):593-597, 1999. 
        26. Hens JR, Wilson KM, Dann P, Chen X, Horowitz MC, Wysolmerski JJ. TOPGAL mice show that the canonical Wnt signaling pathway is active during bone development and growth and is activated by mechanical loading in vitro. J Bone Miner Res 20(7):1103-1113, 2005. 
        27. Ho AM, Marker PC, Peng H, Quintero AJ, Kingsley DM, Huard J. Dominant negative Bmp5 mutation reveals key role of BMPs in skeletal response to mechanical stimulation. BMC Dev Biol 8:35, 2008.
        28. Jansen JH, Weyts FA, Westbroek I, Jahr H, Chiba H, Pols HA, Verhaar JA, van Leeuwen JP, Weinans H. Stretch-induced phosphorylation of ERK1/2 depends on differentiation stage of osteoblasts. Journal of Cellular Biochemistry 93:542–551, 2004. 
        29. Kim DW, Lee HJ, Karmin JA, Lee SE, Chang SS, Tolchin B, Lin S, Cho SK, Kwon A, Ahn JM, Lee FY. Mechanical loading differentially regulates membrane-bound and soluble RANKL availability in MC3T3-E1 cells. Ann N Y Acad Sci 1068:568-72., 2006. 
        30. Knoll B, McCarthy TL, Centrella M, Shin J. Strain-dependent control of transforming growth factor- β function in osteoblasts in an in vitro model: biochemical events associated with distraction osteogenesis. Plastic & Reconstructive Surgery 116(1):224-233, 2005. 
        31. Li L, Chen M, Deng L, Mao Y, Wu W, Chang M, Chen H. The effect of mechanical stimulation on the expression of α2, β1, β3 integrins and the proliferation, synthetic function in rat osteoblasts. Sheng Wu Yi Xue Gong Cheng Xue Za Zhi 20(2):187-192, 2003. 
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        心臟血管(Cardio vasculature)細胞牽張拉伸應力應用文獻

        心肌細胞和成纖維細胞(Cardiomyocytes and fibroblasts)牽張拉伸應力應用文獻

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        心血管內皮細胞(Cardiovascular endothelial cells)牽張拉伸應力應用文獻

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        85. Cheng JJ, Wung BS, Chao YJ, Wang DL. Cyclic strain-induced reactive oxygen species involved in ICAM-1 gene induction in endothelial cells. Hypertension 31(1):125-30, 1998. 
        86. Cheng JJ, Wung BS, Chao YJ, Wang DL. Sequential activation of protein kinase C (PKC)-α and PKC-ε contributes to sustained Raf/ERK1/2 activation in endothelial cells under mechanical strain. J Biol Chem 276(33):31368-31375, 2001.
        87. Coen P, Cummins P, Birney Y, Devery R, Cahill P. Modulation of nitric oxide and 6-keto-prostaglandin F(1α) production in bovine aortic endothelial cells by conjugated linoleic acid. Endothelium 11(3-4):211-20, 2004. 
        88. Cohen CR, Mills I, Du W, Kamal K, Sumpio BE. Activation of the adenylyl cyclase/cyclic AMP/protein kinase A pathway in endothelial cells exposed to cyclic strain. Exp Cell Res 231(1):184-189, 1997. 
        89. Cummins PM, Cotter EJ, Cahill PA. Hemodynamic regulation of metallopeptidases within the vasculature. Protein Pept Lett11(5):433-442, 2004. 
        90. Cummins PM, von Offenberg Sweeney N, Killeen MT, Birney YA, Redmond EM, Cahill PA. Cyclic strain-mediated matrix metalloproteinase regulation within the vascular endothelium: a force to be reckoned with. Am J Physiol Heart Circ Physiol 292:H28–H42, 2007. 
        91. Dekker RJ, van Thienen JV, Rohlena J, de Jager SC, Elderkamp YW, Seppen J, de Vries CJ, Biessen EA, van Berkel TJ, Pannekoek H, Horrevoets AJ. Endothelial KLF2 links local arterial shear stress levels to the expression of vascular tone-regulating genes. Am J Pathol 167(2):609-618, 2005. 
        92. Du W, Mills I, Sumpio BE. Cyclic strain causes heterogeneous induction of transcription factors, AP-1, CRE binding protein and NF-kB, in endothelial cells: species and vascular bed diversity. Journal of Biomechanics 28(12):1485-149, 1995. 
        93. Evans L, Frenkel L, Brophy CM, Rosales O, Sudhaker CB, Li G, Du W, Sumpio BE. Activation of diacylglycerol in cultured endothelial cells exposed to cyclic strain. Am J Physiol 272(2 Pt 1):C650-C656, 1997. 
        94. Fisslthaler B, Boengler K, Fleming I, Schaper W, Busse R, Deindl E. Identification of a cis-element regulating transcriptional activity in response to fluid shear stress in bovine aortic endothelial cells. Endothelium 10(4-5):267-75, 2003. 
        95. Fisslthaler B, Popp R, Michaelis UR, Kiss L, Fleming I, Busse R. Cyclic stretch enhances the expression and activity of coronary endothelium-derived hyperpolarizing factor synthase. Hypertension 38(6):1427-1432, 2001. 
        96. Fujioka K, Azuma N, Kito H, Gahtan V, Esato K, Sumpio BE. Role of caveolin in hemodynamic force-mediated endothelial changes. J Surg Res 92(1):7-10, 2000. 
        97. Ghosh K, Thodeti CK, Dudley AC, Mammoto A, Klagsbrun M, Ingber DE. Tumor-derived endothelial cells exhibit aberrant Rho-mediated mechanosensing and abnormal angiogenesis in vitro. Proc Natl Acad Sci U S A 105(32):11305-11310, 2008. Epub 2008 Aug 6. 
        98. Goettsch C, Goettsch W, Arsov A, Hofbauer LC, Bornstein SR, Morawietz H. Long-term cyclic strain downregulates endothelial Nox4. Antioxid Redox Signal 11(10):2385-2397, 2009. 
        99. Grigoryev DN, Ma SF, Irizarry RA, Ye SQ, Quackenbush J, Garcia JG. Orthologous gene-expression profiling in multi-species models: search for candidate genes. Genome Biol 5(5):R34, 2004. Epub 2004 Apr 27. 
        100. Haga M, Chen A, Gortler D, Dardik A, Sumpio BE. Shear stress and cyclic strain may suppress apoptosis in endothelial cells by different pathways. Endothelium 10(3):149-57, 2003. 
        101. Hishikawa K, Luscher TF. Pulsatile stretch stimulates superoxide production in human aortic endothelial cells. Circulation96(10):3610-3616, 1997.
        102. Hoshino Y, Nishimura K, Sumpio BE. Phosphatase PTEN is inactivated in bovine aortic endothelial cells exposed to cyclic strain. J Cell Biochem 100(2):515-526, 2007. 
        103. Howard AB, Alexander RW, Nerem RM, Griendling KK, Taylor WR. Cyclic strain induces an oxidative stress in endothelial cells. Am J Physiol Cell Physiol 272(2):C421-C427, 1997. 
        104. Iba T, Mills I, Sumpio BE. Intracellular cyclic AMP levels in endothelial cells subjected to cyclic strain in vitro. J Surg Res52(6):625-630, 1992. 
        105. Iba T, Shin T, Sonoda T, Rosales O, Sumpio BE. Stimulation of endothelial secretion of tissue-type plasminogen activator by repetitive stretch. J Surg Res 50(5):457-460, 1991. 
        106. Iba T, Sumpio BE. Morphological response of human endothelial cells subjected to cyclic strain in vitro. Microvasc Res42(3):245-254, 1991. 
        107. Ikeda M, Kito H, Sumpio BE. Phosphatidylinositol-3 kinase dependent MAP kinase activation via p21ras in endothelial cells exposed to cyclic strain. Biochem Biophys Res Commun 257(3):668-671, 1999. 
        108. Ikeda M, Takei T, Mills I, Kito H, Sumpio BE. Extracellular signal-regulated kinases 1 and 2 activation in endothelial cells exposed to cyclic strain. Am J Physiol Heart Circ Physiol 276:H614-H622, 1999. 
        109. Ikeda M, Takei T, Mills I, Sumpio BE. Calcium-independent activation of extracellular signal-regulated kinases 1 and 2 by cyclic strain. Biochem Biophys Res Commun 247(2):462-465, 1998. 
        110. Juan SH, Chen JJ, Chen CH, Lin H, Cheng CF, Liu JC, Hsieh MH, Chen YL, Chao HH, Chen TH, Chan P, Cheng TH. 17β-estradiol inhibits cyclic strain-induced endothelin-1 gene expression within vascular endothelial cells. Am J Physiol Heart Circ Physiol287(3):H1254-H1261, 2004. 
        111. Kim JI, Cordova AC, Hirayama Y, Madri JA, Sumpio BE. Differential effects of shear stress and cyclic strain on Sp1 phosphorylation by protein kinase Czeta modulates membrane type 1-matrix metalloproteinase in endothelial cells. Endothelium 15(1):33-42, 2008. 
        112. Kito H, Yokoyama C, Inoue H, Tanabe T, Nakajima N, Sumpio BE. Cyclooxygenase expression in bovine aortic endothelial cells exposed to cyclic strain. Endothelium 6(2):107-112, 1998. 
        113. Korff T, Aufgebauer K, Hecker M. Cyclic stretch controls the expression of CD40 in endothelial cells by changing their transforming growth factor-β1 response. Circulation 116(20):2288-2297, 2007. Epub 2007 Oct 29. 
        114. Kou B, Zhang J, Singer DR. Effects of cyclic strain on endothelial cell apoptosis and tubulogenesis are dependent on ROS production via NAD(P)H subunit p22phox. Microvasc Res 77(2):125-133, 2009. Epub 2008 Aug 27. 
        115. Lauth M, Cattaruzza M, Hecker M. ACE inhibitor and AT1 antagonist blockade of deformation-induced gene expression in the rabbit jugular vein through B2 receptor activation. Arterioscler Thromb Vasc Biol 21(1):61-6, 2001. 
        116. Lauth M, Wagner AH, Cattaruzza M, Orzechowski HD, Paul M, Hecker M. Transcriptional control of deformation-induced preproendothelin-1 gene expression in endothelial cells. J Mol Med 78(8):441-450, 2000.
        117. Lee T, Kim SJ, Sumpio BE. Role of PP2A in the regulation of p38 MAPK activation in bovine aortic endothelial cells exposed to cyclic strain. J Cell Physiol 194(3):349-355, 2003. 
        118. Li W, Sumpio BE. Strain-induced vascular endothelial cell proliferation requires PI3K-dependent mTOR-4E-BP1 signal pathway. Am J Physiol Heart Circ Physiol 288(4):H1591-1597, 2005. 
        119. Metzler SA, Pregonero CA, Butcher JT, Burgess SC, Warnock JN. Cyclic strain regulates pro-inflammatory protein expression in porcine aortic valve endothelial cells. J Heart Valve Dis 17(5):571-577, 2008. 
        120. Moldobaeva A, Jenkins J, Wagner E. Effects of distension on airway inflammation and venular P-selectin expression. Am J Physiol Lung Cell Mol Physiol 295(5):L941-L948, 2008. Epub 2008 Sep 19. 
        121. Morrow D, Cullen JP, Cahill PA, Redmond EM. Cyclic strain regulates the Notch/CBF-1 signaling pathway in endothelial cells: role in angiogenic activity. Arterioscler Thromb Vasc Biol 27:1289-1296, 2007. 
        122. Murata K, Mills I, Sumpio BE. Protein phosphatase 2A in stretch-induced endothelial cell proliferation. J Cell Biochem63(3):311-319, 1996. 
        123. Nishimura K, Li W, Hoshino Y, Kadohama T, Asada H, Ohgi S, Sumpio BE. Role of AKT in cyclic strain-induced endothelial cell proliferation and survival. Am J Physiol Cell Physiol 290(3):C812-C821, 2006. 
        124. Okada M, Matsumori A, Ono K, Furukawa Y, Shioi T, Iwasaki A, Matsushima K, Sasayama S. Cyclic stretch upregulates production of interleukin-8 and monocyte chemotactic and activating factor/monocyte chemoattractant protein-1 in human endothelial cells. Arterioscler Thromb Vasc Biol 18(6):894-901, 1998.

        125. Pikkarainen S, Tokola H, Kerkela R, Ilves M, Makinen M, Orzechowski HD, Paul M, Vuolteenaho O, Ruskoaho H. Inverse regulation of preproendothelin-1 and endothelin-converting enzyme-1β genes in cardiac cells by mechanical load. Am J Physiol Regul Integr Comp Physiol 290(6):R1639-R1645, 2006. 
        126. Rakugi H, Yu H, Kamitani A, Nakamura Y, Ohishi M, Kamide K, Nakata Y, Takami S, Higaki J, Ogihara T. Links between hypertension and myocardial infarction. American Heart Journal 132(1 Pt 2 Su):213-221, 1996. 
        127. Regnault V, Perret-Guillaume C, Kearney-Schwartz A, Max JP, Labat C, Louis H, Wahl D, Pannier B, Lecompte T, Weryha G, Challande P, Safar ME, Benetos A, Lacolley P. Tissue factor pathway inhibitor: a new link among arterial stiffness, pulse pressure, and coagulation in postmenopausal women. Arterioscler Thromb Vasc Biol 31(5):1226-1232, 2011. Epub 2011 Feb 3. 
        128. Rosales OR, Isales CM, Barrett PQ, Brophy C, Sumpio BE. Exposure of endothelial cells to cyclic strain induces elevations of cytosolic Ca2+ concentration through mobilization of intracellular and extracellular pools. Biochem J 326(Pt 2):385-92, 1997. 
        129. Rosales OR, Sumpio BE. Changes in cyclic strain increase inositol trisphosphate and diacylglycerol in endothelial cells. Am J Physiol Cell Physiol 262(4):C956-C962, 1992. 
        130. Schneider SW, Yano Y, Sumpio BE, Jena BP, Geibel JP, Gekle M, Oberleithner H. Rapid aldosterone-induced cell volume increase of endothelial cells measured by the atomic force microscope. Cell Biol Int 21(11):759-768, 1997. 
        131. Segurola RJ Jr, Oluwole B, Mills I, Yokoyama C, Tanabe T, Kito H, Nakajima N, Sumpio BE. Cyclic strain is a weak inducer of prostacyclin synthase expression in bovine aortic endothelial cells. J Surg Res 69(1):135-138, 1997. 
        132. Sumpio BE, Banes AJ, Buckley M, Johnson G Jr. Alterations in aortic endothelial cell morphology and cytoskeletal protein synthesis during cyclic tensional deformation. J Vasc Surg 7(1):130-138, 1988. 
        133. Sumpio BE, Banes AJ, Levin LG, Johnson G Jr. Mechanical stress stimulates aortic endothelial cells to proliferate. J Vasc Surg 6(3):252-256, 1987. 
        134. Sumpio BE, Banes AJ, Link GW, Iba T. Modulation of endothelial cell phenotype by cyclic stretch: inhibition of collagen production. J Surg Res 48(5):415-420, 1990. 
        135. Sumpio BE, Banes AJ. Prostacyclin synthetic activity in cultured aortic endothelial cells undergoing cyclic mechanical deformation. Surgery 104(2):383-389, 1988. 
        136. Sumpio BE, Chang R, Xu WJ, Wang XJ, Du W. Regulation of tPA in endothelial cells exposed to cyclic strain: role of CRE, AP-2, and SSRE binding sites. Am J Physiol Cell Physiol 273:C1441-C1448, 1997. 
        137. Sumpio BE, Du W, Galagher G, Wang X, Khachigian LM, Collins T, Gimbrone MA Jr, Resnick N. Regulation of PDGF-B in endothelial cells exposed to cyclic strain. Arterioscler Thromb Vasc Biol 18(3):349-355, 1998. 
        138. Thodeti CK, Matthews B, Ravi A, Mammoto A, Ghosh K, Bracha AL, Ingber DE. TRPV4 channels mediate cyclic strain-induced endothelial cell reorientation through integrin-to-integrin signaling. Circ Res 104(9):1123-1130, 2009. Epub 2009 Apr 9. 
        139. Tomanek RJ, Zheng W. Role of growth factors in coronary morphogenesis. Tex Heart Inst J 29(4):250-254, 2002. 
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        141. Upchurch GR Jr, Loscalzo J, Banes AJ. Changes in the amplitude of cyclic load biphasically modulate endothelial cell DNA synthesis and division. Vasc Med 2(1):19-24, 1997. 
        142. van Wamel AJ, Ruwhof C, van der Valk-Kokshoom LE, Schrier PI, van der Laarse A. The role of angiotensin II, endothelin-1 and transforming growth factor-β as autocrine/paracrine mediators of stretch-induced cardiomyocyte hypertrophy. Mol Cell Biochem218(1-2):113-124, 2001. 
        143. van Wamel AJ, Ruwhof C, van der Valk-Kokshoorn LJ, Schrier PI, van der Laarse A. Stretch-induced paracrine hypertrophic stimuli increase TGF-β1 expression in cardiomyocytes. Mol Cell Biochem 236(1-2):147-153, 2002. 
        144. Vollmer T, Hinse D, Kleesiek K, Dreier J. Interactions between endocarditis-derived Streptococcus gallolyticus subsp. Gallolyticus isolates and human endothelial cells. BMC Microbiology 10:78, 2010. 
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        149. Wang DL, Wung BS, Peng YC, Wang JJ. Mechanical strain increases endothelin-1 gene expression via protein kinase C pathway in human endothelial cells. J Cell Physiol 163(2):400-406, 1995. 
        150. Wang DL, Wung BS, Shyy YJ, Lin CF, Chao YJ, Usami S, Chien S. Mechanical strain induces monocyte chemotactic protein-1 gene expression in endothelial cells. Effects of mechanical strain on monocyte adhesion to endothelial cells. Circ Res 77(2):294-302, 1995. 
        151. Widmann MD, Letsou GV, Phan S, Baldwin JC, Sumpio BE. Isolation and characterization of rabbit cardiac endothelial cells: Response to cyclic strain and growth factors in vitro. Journal of Surgical Research 53(4):331-334, 1992. 
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        155. Wung BS, Cheng JJ, Chao YJ, Hsieh HJ, Wang DL. Modulation of Ras/Raf/extracellular signal-regulated kinase pathway by reactive oxygen species is involved in cyclic strain-induced early growth response-1 gene expression in endothelial cells. Circ Res84(7):804-812, 1999. 
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        158. Wung BS, Cheng JJ, Shyue SK, Wang DL. NO modulates monocyte chemotactic protein-1 expression in endothelial cells under cyclic strain. Arterioscler Thromb Vasc Biol 21(12):1941-1947, 2001. 
        159. Yamaguchi S, Yamaguchi M, Yatsuyanagi E, Yun SS, Nakajima N, Madri JA, Sumpio BE. Cyclic strain stimulates early growth response gene product 1-mediated expression of membrane type 1 matrix metalloproteinase in endothelium. Lab Invest 82(7):949-956, 2002. 
        160. Yano Y, Geibel J, Sumpio BE. Cyclic strain induces reorganization of integrin α5β1 and α2β1 in human umbilical vein endothelial cells. J Cell Biochem 64(3):505-513, 1997. 
        161. Yano Y, Geibel J, Sumpio BE. Tyrosine phosphorylation of pp125FAK and paxillin in aortic endothelial cells induced by mechanical strain. Am J Physiol Cell Physiol 271:C635-C649, 1996. 
        162. Yano Y, Saito Y, Narumiya S, Sumpio BE. Involvement of rho p21 in cyclic strain-induced tyrosine phosphorylation of focal adhesion kinase (pp125FAK), morphological changes and migration of endothelial cells. Biochem Biophys Res Commun 224(2):508-515, 1996. 
        163. Zheng W, Christensen LP, Tomanek RJ. Stretch induces upregulation of key tyrosine kinase receptors in microvascular endothelial cells. Am J Physiol Heart Circ Physiol 287(6):H2739-H2745, 2004. 
        164. Zheng W, Seftor EA, Meininger CJ, Hendrix MJ, Tomanek RJ. Mechanisms of coronary angiogenesis in response to stretch: role of VEGF and TGF-β. Am J Physiol Heart Circ Physiol 280(2):H909-H917, 2001. 
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        心血管平滑肌細胞(Cardiovascular smooth muscle cells)牽張拉伸應力應用文獻

        166. Allison DA, Wight TN, Ripp NJ, Braun KR, Grande-Allen KJ. Endogenous overexpression of hyaluronan synthases within dynamically cultured collagen gels: Implications for vascular and valvular disease. Biomaterials 29:2969-2976, 2008. 
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        176. Cheng J, Zhang J, Merched A, Zhang L, Zhang P, Truong L, Boriek AM, Du J. Mechanical stretch inhibits oxidized low density lipoprotein-induced apoptosis in vascular smooth muscle cells by up-regulating integrin αVβ3 and stablization of PINCH-1. J Biol Chem 282(47):34268-34275, 2007. Epub 2007 Sep 18. 
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        其他心血管細胞(Other cardiovascular cells)牽張拉伸應力應用文獻

        283. Balguid A, Rubbens MP, Mol A, Bank RA, Bogers AJ, van Kats JP, de Mol BA, Baaijens FP, Bouten CV. The role of collagen cross-links in biomechanical behavior of human aortic heart valve leaflets - relevance for tissue engineering. Tissue Eng13(7):1501-1511, 2007. 
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        294. Tobita K, Garrison JB, Keller BB. Differential effects of cyclic stretch on embryonic ventricular cardiomyocyte and non-cardiomyocyte orientation. Edited by Clark EB, Nakazawa M, Takao A. Blackwell Futura Publishing:177-179, 2005. 
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        軟骨(Cartilage)細胞牽張拉伸應力應用文獻

        關節軟骨細胞(Articular chondrocytes)牽張拉伸應力應用文獻

        1. Agarwal S, Deschner J, Long P, Verma A, Hofman C, Evans CH, Piesco N. Role of NF-κB transcription factors in antiinflammatory and proinflammatory actions of mechanical signals. Arthritis Rheum 50(11):3541-3548, 2004.
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        8. Gassner R, Buckley MJ, Piesco N, Evans C, Agarwal S. Cytokine-induced nitric oxide production of joint cartilage cells in continuous passive movement. Anti-inflammatory effect of continuous passive movement on chondrocytes: in vitro study. Mund Kiefer Gesichtschir 4 Suppl 2:S479-S484, 2000. [Article in German]
        9. Gassner RJ, Buckley MJ, Studer RK, Evans CH, Agarwal S. Interaction of strain and interleukin-1 in articular cartilage: effects on proteoglycan synthesis in chondrocytes. International Journal of Oral & Maxillofacial Surgery 29(5):389-394, 2000.
        10. Holmvall K, Camper L, Johansson S, Kimura JH, Lundgren-Akerlund E. Chondrocyte and chondrosarcoma cell integrins with affinity for collagen type II and their response to mechanical stress. Exp Cell Res 221(2):496-503, 1995.
        11. Honda K, Ohno S, Tanimoto K, Ijuin C, Tanaka N, Doi T, Kato Y, Tanne K. The effects of high magnitude cyclic tensile load on cartilage matrix metabolism in cultured chondrocytes. Eur J Cell Biol 79(9):601-609, 2000.
        12. Huang J, Ballou LR, Hasty KA. Cyclic equibiaxial tensile strain induces both anabolic and catabolic responses in articular chondrocytes. Gene 404:101–109, 2007.
        13. Huang J, Eckstein E, Hasty KA. Increased production of MMP-2 induced by cyclic tensile strain from porcine articular chondrocytes is not surpressed by iNOS and COX inhibitors [abstract]. Transactions of the 51st Annual Meeting Orthopaedic Research Society 30:1468, 2005
        14. Huang J, Rho JY, Eckstein E, Hasty KA. Cyclic tension stress on porcine articular chondrocytes increases the production of nitric oxide and prostaglandin E2 in a coordinated manner [abstract]. Transactions of the 50th Annual Meeting Orthopaedic Research Society 29:825, 2004.
        15. Huang J, Rho JY, Hasty KA. Cyclic tension stress regulates the metabolism of articular chondrocytes via different pathways [abstract]. Transactions of the 49th Annual Meeting Orthopaedic Research Society 28:640, 2003.
        16. Iimoto S, Watanabe S, Takahashi T, Shimizu A, Yamamoto H. The influence of Celecoxib on matrix synthesis by chondrocytes under mechanical stress in vitro. Int J Mol Med 16(6):1083-1088, 2005.
        17. Kawakita K, Nishiyama T, Fujishiro T, Hayashi S, Kanzaki N, Hashimoto S, Takebe K, Iwasa K, Sakata S, Nishida K, Kuroda R, Kurosaka M. Akt phosphorylation in human chondrocytes is regulated by p53R2 in response to mechanical stress.Osteoarthritis Cartilage 2012 Sep 3. pii: S1063-4584(12)00945-4. doi: 10.1016/j.joca.2012.08.022. [Epub ahead of print].
        18. Lahiji K, Polotsky A, Hungerford DS, Frondoza CG. Cyclic strain stimulates proliferative capacity, α2 and α5 integrin, gene marker expression by human articular chondrocytes propagated on flexible silicone membranes. In Vitro Cell Dev Biol Anim40(5-6):138-142, 2004.
        19. Long P, Gassner R, Agarwal S. Tumor necrosis factor α-dependent proinflammatory gene induction is inhibited by cyclic tensile strain in articular chondrocytes in vitro. Arthritis Rheum 44(10):2311-9, 2001
        20. Madhavan S, Anghelina M, Rath-Deschner B, Wypasek E, John A, Deschner J, Piesco N, Agarwal S. Biomechanical signals exert sustained attenuation of proinflammatory gene induction in articular chondrocytes. Osteoarthritis Cartilage 14(10):1023-32, 2006. Epub 2006 May 30.
        21. Marques MR, Hajjar D, Franchini KG, Moriscot AS, Santos MF. Mandibular appliance modulates condylar growth through integrins. J Dent Res 87(2):153-158, 2008.
        22. Matsukawa M, Fukuda K, Yamasaki K, Yoshida K, Munakata H, Hamanishi C. Enhancement of nitric oxide and proteoglycan synthesis due to cyclic tensile strain loaded on chondrocytes attached to fibronectin. Inflamm Res 53(6):239-44, 2004.
        23. Matsushita T, Fukuda K, Yamamoto H, Yamazaki K, Tomiyama T, Oh M, Hamanishi C. Effect of ebselen, a scavenger of reactive oxygen species, on chondrocyte metabolism. Mod Rheumatol 14(1):25-30, 2004.
        24. Nishida K, Doi H, Shimizu A, Yorimitsu M, Takigawa M, Inoue H. The role of IL-4 in the control of mechanical stress-induced inflammatory mediators by rat chondrocytes [abstract]. Arthritis Res Ther 5(Suppl 3):57, 2003.
        25. Rath B, Springorum HR, Deschner J, Luring C, Tingart M, Grifka J, Schaumburger J, Grassel S. Regulation of gene expression in articular cells is influenced by biomechanicalloading. Central European Journal of Medicine 2012, doi: 10.2478/s11536-012-0008-x.
        26. Shelton JC, Bader DL, Lee DA. Mechanical conditioning influences the metabolic response of cell-seeded constructs. Cells Tissues Organs 175(3):140-150, 2003.
        27. Shimizu A, Watanabe S, Iimoto S, Yamamoto H. Interleukin-4 protects matrix synthesis in chondrocytes under excessive mechanical stress in vitro. Modern Rheumatology 14(4):296-300, 2004.
        28. Tanaka S, Hamanishi C, Kikuchi H, Fukuda K. Factors related to degradation of articular cartilage in osteoarthritis: a review. Semin Arthritis Rheum 27(6):392-399, 1998.
        29. Thomas RS, Clarke AR, Duance VC, Blain EJ. Effects of Wnt3A and mechanical load on cartilage chondrocyte homeostasis.Arthritis Res Ther 13(6):R203, 2011. Epub 2011 Dec 9.
        30. Xu HG, Zhang XH, Wang H, Liu P, Wang LT, Zuo CJ, Tong WX, Zhang XL. Intermittent cyclic mechanical tension-induced calcification and downregulation of ankh gene expression of end plate chondrocytes. Spine (Phila Pa 1976) 37(14):1192-1197, 2012.
        31. Yamazaki K, Fukuda K, Matsukawa M, Hara F, Matsushita T, Yamamoto N, Yoshida K, Munakata H, Hamanishi C. Cyclic tensile stretch loaded on bovine chondrocytes causes depolymerization of hyaluronan: involvement of reactive oxygen species.Arthritis Rheum 48(11):3151-3158, 2003.

         

        其他的軟骨細胞(Other cartilage cells)牽張拉伸應力應用文獻

        32. Agarwal S, Long P, Gassner R, Piesco NP, Buckley MJ. Cyclic tensile strain suppresses catabolic effects of interleukin-1β in fibrochondrocytes from the temporomandibular joint. Arthritis Rheum 44(3):608-617, 2001. 
        33. Chano T, Tanaka M, Hukuda S, Saeki Y. Mechanical stress induces the expression of high molecular mass heat shock protein in human chondrocytic cell line CS-OKB. Osteoarthritis Cartilage 8(2):115-119, 2000. 
        34. Deschner J, Rath-Deschner B, Agarwal S. Regulation of matrix metalloproteinase expression by dynamic tensile strain in rat fibrochondrocytes. Osteoarthritis Cartilage 14(3):264-272, 2006. Epub 2005 Nov 14. 
        35. Deschner J, Rath-Deschner B, Wypasek E, Anghelina M, Sjostrom D, Agarwal S. Biomechanical strain regulates TNFR2 but not TNFR1 in TMJ cells. J Biomech 40(7):1541-1549, 2007. Epub 2006 Oct 16. 
        36. Madhavan S, Anghelina M, Sjostrom D, Dossumbekova A, Guttridge DC, Agarwal S. Biomechanical signals suppress TAK1 activation to inhibit NF-κB transcriptional activation in fibrochondrocytes. J Immunol 179(9):6246-6254, 2007. 
        37. Ohno S, Tanaka N, Ueki M, Honda K, Tanimoto K, Yoneno K, Ohno-Nakahara M, Fujimoto K, Kato Y, Tanne K. Mechanical regulation of terminal chondrocyte differentiation via RGD-CAP/β ig-h3 induced by TGF-β. Connect Tissue Res 46(4-5):227-234, 2005. 
        38. Rath B, Springorum HR, Deschner J, Luring C, Tingart M, Grifka J, Schaumburger J, Grassel S. Regulation of gene expression in articular cells is influenced by biomechanicalloading. Central European Journal of Medicine 2012, doi: 10.2478/s11536-012-0008-x. 
        39. Ru-song Z, Zhu-li Y, Yan-xiao D, Chong-ying Y, Ping-ping J, Xiao Y. Effect of tensile stress on type II collagen and aggrecan expression in rat condylar chondrocytes. Chinese Journal of Tissue Engineering Research 16(20): 3649-3653, 2012. 
        40. Tanaka N, Ohno S, Honda K, Tanimoto K, Doi T, Ohno-Nakahara M, Tafolla E, Kapila S, Tanne K. Cyclic mechanical strain regulates the PTHrP expression in cultured chondrocytes via activation of the Ca2+ channel. J Dent Res 84(1):64-68, 2005. 
        41. Tanimoto K, Kamiya T, Tanne Y, Kunimatsu R, Mitsuyoshi T, Tanaka E, Tanne K. Superficial zone protein affects boundary lubrication on the surface of mandibular condylar cartilage. Cell Tissue Res 344(2):333-340, 2011. Epub 2011 Apr 12. 
        42. Ueki M, Tanaka N, Tanimoto K, Nishio C, Honda K, Lin YY, Tanne Y, Ohkuma S, Kamiya T, Tanaka E, Tanne K. The effect of mechanical loading on the metabolism of growth plate chondrocytes. Ann Biomed Eng 36(5):793-800, 2008. Epub 2008 Feb 16.

        皮膚成纖維細胞(Dermal Fibroblasts)牽張拉伸應力應用文獻

        1. Kessler D, Dethlefsen S, Haase I, Plomann M, Hirche F, Krieg T, Eckes B. Fibroblasts in mechanically stressed collagen lattices assume a "synthetic" phenotype. J Biol Chem 276(39):36575-36585, 2001.
        2. Meltzer KR, Cao TV, Schad JF, King H, Stoll ST, Standley PR. In vitro modeling of repetitive motion injury and myofascial release. J Bodyw Mov Ther 14(2):162-171, 2010. Epub 2010 Jan 29.
        3. Meltzer KR, Standley PR. Modeled repetitive motion strain and indirect osteopathic manipulative techniques in regulation of human fibroblast proliferation and interleukin secretion. J Am Osteopath Assoc 107(12):527-536, 2007.
        4. Parsons M, Kessler E, Laurent GJ, Brown RA, Bishop JE. Mechanical load enhances procollagen processing in dermal fibroblasts by regulating levels of procollagen C-proteinase. Exp Cell Res 252(2):319-331, 1999.
        5. Shelton JC, Bader DL, Lee DA. Mechanical conditioning influences the metabolic response of cell-seeded constructs. Cells Tissues Organs 175(3):140-150, 2003.

        內皮細胞(Endothelial cells)牽張拉伸應力應用文獻

        心血管內皮細胞(Cardiovascular endothelial cells)牽張拉伸應力應用文獻

        See page 13

        肺動脈內皮細胞(Pulmonary endothelial cells)細胞牽張拉伸應力應用文獻

        See page 46

        其他的內皮細胞(Other endothelial cells)細胞牽張拉伸應力應用文獻

        1. Milkiewicz M, Doyle JL, Fudalewski T, Ispanovic E, Aghasi M, Haas TL. HIF-1α and HIF-2α play a central role in stretch-induced but not shear-stress-induced angiogenesis in rat skeletal muscle. J Physiol 583(Pt 2):753-766, 2007. Epub 2007 Jul 12. 
        2. Milkiewicz M, Mohammadzadeh F, Ispanovic E, Gee E, Haas TL. Static strain stimulates expression of matrix metalloproteinase-2 and VEGF in microvascular endothelium via JNK- and ERK-dependent pathways. J Cell Biochem 100(3):750-761, 2007. 
        3. Suzuma I, Hata Y, Clermont A, Pokras F, Rook SL, Suzuma K, Feener EP, Aiello L. Cyclic stretch and hypertension induce retinal expression of vascular endothelial growth factor and vascular endothelial growth factor receptor–2: potential mechanisms for exacerbation of diabetic retinopathy by hypertension. Diabetes 50:444–454, 2001. 
        4. Vollmer T, Hinse D, Kleesiek K, Dreier J. Interactions between endocarditis-derived Streptococcus gallolyticus subsp. gallolyticus isolates and human endothelial cells. BMC Microbiol 10:78, 2010. 
        5. Yun S, Dardik A, Haga M, Yamashita A, Yamaguchi S, Koh Y, Madri JA, Sumpio BE. Transcription factor Sp1 phosphorylation induced by shear stress inhibits membrane type 1-matrix metalloproteinase expression in endothelium. J Biol Chem 277(38):34808-34814, 2002.

        上皮細胞(Epithelial Cells)細胞牽張拉伸應力應用文獻

        Caco-2腸上皮細胞(Caco-2 intenstinal epithelial cells)細胞牽張拉伸應力應用文獻

        1. Basson MD, Li GD, Hong F, Han O, Sumpio BE. Amplitude-dependent modulation of brush border enzymes and proliferation by cyclic strain in human intestinal Caco-2 monolayers. J Cell Physiol 168(2):476-488, 1996.
        2. Chaturvedi LS, Marsh HM, Shang X, Zheng Y, Basson MD. Repetitive deformation activates focal adhesion kinase and ERK mitogenic signals in human Caco-2 intestinal epithelial cells through Src and Rac1. J Biol Chem 282(1):14-28, 2007.
        3. Chaturvedi LS, Gayer CP, Marsh HM, Basson MD. Repetitive deformation activates Src-independent FAK-dependent ERK motogenic signals in human Caco-2 intestinal epithelial cells. Am J Physiol Cell Physiol 294:C1350–C1361, 2008.
        4. Craig DH, Zhang J, Basson MD.Cytoskeletal signaling by way of α-actinin-1 mediates ERK1/2 activation by repetitive deformation in human Caco2 intestinal epithelial cells. Am J Surg 194(5):618-622, 2007.
        5. Gayer CP, Chaturvedi LS, Wang S, Craig DH, Flanigan T, Basson MD. Strain-induced proliferation requires the phosphatidylinositol 3-kinase/AKT/glycogen synthase kinase pathway. J Biol Chem 284:2001-2011, 2009.
        6. Gayer CP, Chaturvedi LS, Wang S, Alston B, Flanigan TL, Basson MD. Delineating the signals by which repetitive deformation stimulates intestinal epithelial migration across fibronectin. Am J Physiol Gastrointest Liver Physiol 296(4):G876-G885, 2009. Epub 2009 Jan 29.
        7. Han O, Li GD, Sumpio BE, Basson MD. Strain induces Caco-2 intestinal epithelial proliferation and differentiation via PKC and tyrosine kinase signals. Am J Physiol 275(3 Pt 1):G534-G541, 1998.
        8. Han O, Sumpio BE, Basson MD. Mechanical strain rapidly redistributes tyrosine phosphorylated proteins in human intestinal Caco-2 cells. Biochem Biophys Res Commun 250(3):668-673, 1998.
        9. Li W, Duzgun A, Sumpio BE, Basson MD. Integrin and FAK-mediated MAPK activation is required for cyclic strain mitogenic effects in Caco-2 cells. Am J Physiol Gastrointest Liver Physiol 280(1):G75-G87, 2001.
        10. Zhang J, Li W, Sanders MA, Sumpio BE, Panja A, Basson MD. Regulation of the intestinal epithelial response to cyclic strain by extracellular matrix proteins. FASEB J 17(8):926-928, 2003. Epub 2003 Mar 5.
        11. Zhang J, Li W, Sumpio BE, Basson MD. Fibronectin blocks p38 and jnk activation by cyclic strain in Caco-2 cells. Biochem Biophys Res Commun 306(3):746-749, 2003.

         

        眼睛的上皮細胞(Eye epithelial cells)細胞牽張拉伸應力應用文獻

        胃上皮細胞(Gastric epithelial cells)細胞牽張拉伸應力應用文獻

        1. Osada T, Iijima K, Tanaka H, Hirose M, Yamamoto J, Watanabe S. Effect of temperature and mechanical strain on gastric epithelial cell line GSM06 wound restoration in vitro. J Gastroenterol Hepatol 14(5):489-494, 1999.

        肺上皮細胞(Pulmonary epithelial cells)細胞牽張拉伸應力應用文獻

        See page 47

        腎小管上皮細胞(Renal epithelial cells)細胞牽張拉伸應力應用文獻

        See page 41

        其他上皮細胞(Other epithelial cells)細胞牽張拉伸應力應用文獻

        13. Amura CR, Brodsky KS, Gitomer B, McFann K, Lazennec G, Nichols MT, Jani A, Schrier RW, Doctor RB. CXCR2 agonists in ADPKD liver cyst fluids promote cell proliferation. Am J Physiol Cell Physiol 294(3):C786-C796, 2008. Epub 2008 Jan 16. 
        14. Haku K, Muramatsu T, Hara A, Kikuchi A, Hashimoto S, Inoue T, Shimono M. Epithelial cell rests of Malassez modulate cell proliferation, differentiation and apoptosis via gap junctional communication under mechanical stretching in vitro. Bull Tokyo Dent Coll52(4):173-182, 2011. 
        15. Hegarty PK, Watson RW, Coffey RN, Webber MM, Fitzpatrick JM. Effects of cyclic stretch on prostatic cells in culture. J Urol 168(5):2291-2295, 2002. 
        16. Koshihara T, Matsuzaka K, Sato T, Inoue T. Effect of stretching force on the cells of epithelial rests of malassez in vitro.Int J Dent 2010:458408, 2010. Epub 2010 Apr 12. 
        17. Mohan AR, Sooranna SR, Lindstrom TM, Johnson MR, Bennett PR. The effect of mechanical stretch on cyclooxygenase type 2 expression and activator protein-1 and nuclear factor-κB activity in human amnion cells. Endocrinology 148(4):1850-1857, 2007. Epub 2007 Jan 11.

        眼睛(Eye)細胞牽張拉伸應力應用文獻

        1. Fujikura H, Seko Y, Tokoro T, Mochizuki M, Shimokawa H. Involvement of mechanical stretch in the gelatinolytic activity of the fibrous sclera of chicks, in vitro. Japanese Journal of Ophthalmology 46(1):24-30, 2002.
        2. Jobling AI, Gentle A, Metlapally R, McGowan BJ, McBrien NA. Regulation of scleral cell contraction by transforming growth factor-β and stress: competing roles in myopic eye growth. J Biol Chem 284(4):2072-2079, 2009. Epub 2008 Nov 14.
        3. Kirwan RP, Crean JK, Fenerty CH, Clark AF, O’Brien CJ. Effect of cyclical mechanical stretch and exogenous transforming growth factor-β1 on matrix metalloproteinase-2 activity in lamina cribrosa cells from the human optic nerve head. J Glaucoma13(4):327-334, 2004.
        4. Kirwan RP, Fenerty CH, Crean J, Wordinger RJ, Clark AF, O’Brien CJ. Influence of cyclical mechanical strain on extracellular matrix gene expression in human lamina cribrosa cells in vitro. Mol Vis 11:798-810, 2005. 5. Quill B, Docherty NG, Clark AF, O’Brien CJ. The effect of graded cyclic stretching on extracellular matrix-related gene expression profiles in cultured primary human lamina cribrosa cells. Invest Ophthalmol Vis Sci 52(3):1908-1915, 2011.
        5. Shelton L, Rada JS. Effects of cyclic mechanical stretch on extracellular matrix synthesis by human scleral fibroblasts. Exp Eye Res 84(2):314-322, 2007. Epub 2006 Nov 21.
        6. Suzuma I, Hata Y, Clermont A, Pokras F, Rook SL, Suzuma K, Feener EP, Aiello L. Cyclic stretch and hypertension induce retinal expression of vascular endothelial growth factor and vascular endothelial growth factor receptor–2: potential mechanisms for exacerbation of diabetic retinopathy by hypertension. Diabetes 50:444–454, 2001.
        7. Suzuma I, Suzuma K, Takagi H, Kaneto H, Aiello L, Honda Y. 1P-0151 Cyclic stretch induced reactive oxygen species (ROS) enhances apoptosis in porcine retinal pericytes (PRPC) through JNK/SAPK activation [abstract]. Atherosclerosis Supplements4(2):53, 2003.
        8. Suzuma I, Suzuma K, Ueki K, Hata Y, Feener EP, King GL, Aiello LP. Stretch-induced retinal vascular endothelial growth factor expression is mediated by phosphatidylinositol 3-kinase and protein kinase C (PKC)-zeta but not by stretch-induced ERK1/2, Akt, Ras, or classical/novel PKC pathways. J Biol Chem 277(2):1047-1057, 2002.

        眼睛的上皮細胞(Eye epithelial cells)細胞牽張拉伸應力應用文獻

        10. Oh JY, Jung KA, Kim MK, Wee WR, Lee JH. Effect of mechanical strain on human limbal epithelial cells in vitro. Curr Eye Res 31(12):1015-20, 2006. 
        11. Seko Y, Seko Y, Fujikura H, Pang J, Tokoro T, Shimokawa H. Induction of vascular endothelial growth factor after application of mechanical stress to retinal pigment epithelium of the rat in vitro. Invest Ophthalmol Vis Sci 40:3287–3291, 1999.

        眼小梁細胞(Trabecular meshwork cells)細胞牽張拉伸應力應用文獻

        12. Aga M, Bradley JM, Keller KE, Kelley MJ, Acott TS. Specialized podosome- or invadopodia-like structures (PILS) for focal trabecular meshwork extracellular matrix turnover. Invest Ophthalmol Vis Sci 49(12):5353-5365, 2008. Epub 2008 Jul 18. 
        13. Baetz NW, Hoffman EA, Yool AJ, Stamer WD. Role of aquaporin-1 in trabecular meshwork cell homeostasis during mechanical strain. Exp Eye Res 89(1):95-100, 2009. Epub 2009 Mar 4. 
        14. Chow J, Liton PB, Luna C, Wong F, Gonzalez P. Effect of cellular senescence on the P2Y-receptor mediated calcium response in trabecular meshwork cells. Mol Vis 13:1926-1933, 2007. 
        15. Chudgar SM, Deng P, Maddala R, Epstein DL, Rao PV. Regulation of connective tissue growth factor expression in the aqueous humor outflow pathway. Mol Vis 12:1117-1126, 2006. 
        16. Iyer P, Lalane R 3rd, Morris C, Challa P, Vann R, Rao PV. Autotaxin-lysophosphatidic Acid axis is a novel molecular target for lowering intraocular pressure. PLoS One 7(8):e42627, 2012. Epub 2012 Aug 20. 
        17. Liton PB, Liu X, Challa P, Epstein DL, Gonzalez P. Induction of TGF-β1 in the trabecular meshwork under cyclic mechanical stress. J Cell Physiol 205(3):364-71, 2005. 
        18. Liton PB, Li G, Luna C, Gonzalez P, Epstein DL. Cross-talk between TGF-β1 and IL-6 in human trabecular meshwork cells. Mol Vis 15:326-334, 2009. Epub 2009 Feb 11. 
        19. Luna C, Li G, Liton PB, Epstein DL, Gonzalez P. Alterations in gene expression induced by cyclic mechanical stress in trabecular meshwork cells. Mol Vis 15:534-544, 2009. Epub 2009 Mar 11. 
        20. Luna C, Li G, Qiu J, Epstein DL, Gonzalez P. MicroRNA-24 regulates the processing of latent TGFβ1 during cyclic mechanical stress in human trabecular meshwork cells through direct targeting of FURIN. J Cell Physiol 226(5):1407-1414, 2011. doi: 10.1002/jcp.22476. 
        21. WuDunn D. The effect of mechanical strain on matrix metalloproteinase production by bovine trabecular meshwork cells. Curr Eye Res22(5):394-397, 2001.

        牙齦成纖維細胞(Gingival Fibroblasts)細胞牽張拉伸應力應用文獻

        1. Bolcato-Bellemin AL, Elkaim R, Abehsera A, Fausser JL, Haikel H, Tenenbaum H. Expression of mRNAs encoding for a and B integrin subunits, MMPs, and TIMPs in stretched human periodontal ligament and gingival fibroblasts. J Dent Res 79(9):1712-1716, 2000.
        2. Danciu TE, Gagari E, Adam RM, Damoulis PD, Freeman MR. Mechanical strain delivers anti-apoptotic and proliferative signals to gingival fibroblasts. J Dent Res 83(8):596-601, 2004.
        3. Grunheid T, Zentner A. Extracellular matrix synthesis, proliferation and death in mechanically stimulated human gingival fibroblasts in vitro. Clin Oral Investig 9(2):124-130, 2005.
        4. Guo F, Carter DE, Leask A. Mechanical tension increases CCN2/CTGF expression and proliferation in gingival fibroblasts via a TGFβ-dependent mechanism. PLoS One 6(5):e19756, 2011. Epub 2011 May 17.
        5. Kimoto S, Matsuzawa M, Matsubara S, Komatsu T, Uchimura N, Kawase T, Saito S. Cytokine secretion of periodontal ligament fibroblasts derived from human deciduous teeth: effect of mechanical stress on the secretion of transforming growth factor-β1 and macrophage colony stimulating factor. J Periodontal Res 34(5):235-243, 1999.
        6. Morimoto T, Nishihira J, Kohgo T. Immunohistochemical localization of macrophage migration inhibitory factor (MIF) in human gingival tissue and its pathophysiological functions. Histochem Cell Biol 120(4):293-298, 2003.
        7. Yoshino H, Morita I, Murota SI, Ishikawa I. Mechanical stress induces production of angiogenic regulators in cultured human gingival and periodontal ligament fibroblasts. J Periodontal Res 38(4):405-410, 2003.

        椎間盤(Intervertebral Disc)細胞牽張拉伸應力應用文獻

        1. Cho H, Seth A, Warmbold J, Robertson JT, Hasty KA. Aging affects response to cyclic tensile stretch: paradigm for intervertebral disc degeneration. Eur Cell Mater 22:137-45; discussion 145-6, 2011. 
        2. Gilbert HT, Hoyland JA, Freemont AJ, Millward-Sadler SJ. The involvement of interleukin-1 and interleukin-4 in the response of human annulus fibrosus cells to cyclic tensile strain: an altered mechanotransduction pathway with degeneration. Arthritis Res Ther13(1):R8, 2011. 
        3. Gilbert HT, Hoyland JA, Millward-Sadler SJ. The response of human anulus fibrosus cells to cyclic tensile strain is frequency-dependent and altered with disc degeneration. Arthritis Rheum 62(11):3385-3394, 2010. doi: 10.1002/art.27643. 
        4. Matsumoto T, Kawakami M, Kuribayashi K, Takenaka T, Tamaki T. Cyclic mechanical stretch stress increases the growth rate and collagen synthesis of nucleus pulposus cells in vitro. Spine 24(4):315-319, 1999. 
        5. Miyamoto H, Doita M, Nishida K, Yamamoto T, Sumi M, Kurosaka M. Effects of cyclic mechanical stress on the production of inflammatory agents by nucleus pulposus and anulus fibrosus derived cells in vitro. Spine 31(1):4-9, 2006. 
        6. Rannou F, Richette P, Benallaoua M, Francois M, Genries V, Korwin-Zmijowska C, Revel M, Corvol M, Poiraudeau S.Cyclic tensile stretch modulates proteoglycan production by intervertebral disc annulus fibrosus cells through production of nitrite oxide. J Cell Biochem 90(1):148-157, 2003. 
        7. Rannou F, Poiraudeau S, Foltz V, Boiteux M, Corvol M, Revel M. Monolayer anulus fibrosus cell cultures in a mechanically active environment: local culture condition adaptations and cell phenotype study. J Lab Clin Med 136(5):412-421, 2000. 
        8. Zhang YH, Zhao CQ, Jiang LS, Dai LY. Lentiviral shRNA silencing of CHOP inhibits apoptosis induced by cyclic stretch in rat annular cells and attenuates disc degeneration in the rats. Apoptosis 16(6):594-605, 2011. 
        9. Zhang Y, Zhao C, Jiang L, Dai L. Cyclic stretch-induced apoptosis in rat annulus fibrosus cells is mediated in part by endoplasmic reticulum stress through nitric oxide production. European Spine Journal 20(8):1233-1243, 2011.

        角質形成細胞(Keratinocytes)細胞牽張拉伸應力應用文獻

        1. Choi K, Mollapour E, Shears SB. Signal transduction during environmental stress: InsP8 operates within highly restricted contexts. Cellular Signalling 17(12):1533-1541, 2005. 
        2. Rouse JG, Haslauer CM, Loboa EG, Monteiro-Riviere NA. Cyclic tensile strain increases interactions between human epidermal keratinocytes and quantum dot nanoparticles. Toxicology in Vitro 22(2):491-497, 2008. 
        3. Russell D, Andrews PD, James J, Lane EB. Mechanical stress induces profound remodelling of keratin filaments and cell junctions in epidermolysis bullosa simplex keratinocytes. J Cell Sci 117(Pt 22):5233-5243, 2004. 
        4. Takei T, Han O, Ikeda M, Male P, Mills I, Sumpio BE. Cyclic strain stimulates isoform-specific PKC activation and translocation in cultured human keratinocytes. J Cell Biochem 67(3):327-337, 1997. 
        5. Takei T, Kito H, Du W, Mills I, Sumpio BE. Induction of interleukin (IL)-1α and β gene expression in human keratinocytes exposed to repetitive strain: their role in strain-induced keratinocyte proliferation and morphological change. J Cell Biochem 69(2):95-103, 1998. 
        6. Takei T, Rivas-Gotz C, Delling CA, Koo JT, Mills I, McCarthy TL, Centrella M, Sumpio BE. Effect of strain on human keratinocytes in vitro. J Cell Physiol 173(1):64-72, 1997.

        腎(Kidney)細胞牽張拉伸應力應用文獻

        1. Alexander LD, Alagarsamy S, Douglas JG. Cyclic stretch-induced cPLA2 mediates ERK 1/2 signaling in rabbit proximal tubule cells. Kidney International 65(2):551-563, 2004. 
        2. Barutta F, Pinach S, Giunti S, Vittone F, Forbes JM, Chiarle R, Arnstein M, Perin PC, Camussi G, Cooper ME, Gruden G. Heat shock protein expression in diabetic nephropathy. Am J Physiol Renal Physiol 295(6):F1817-F1824, 2008. Epub 2008 Oct 15. 
        3. Carey RM, McGrath HE, Pentz ES, Gomez RA, Barrett PQ. Biomechanical coupling in renin-releasing cells. J Clin Invest100(6):1566-1574, 1997. 
        4. Diamond JR, Kreisberg R, Evans R, Nguyen TA, Ricardo SD. Regulation of proximal tubular osteopontin in experimental hydronephrosis in the rat. Kidney International 54(5):1501-1509, 1998. 
        5. Durvasula RV, Petermann AT, Hiromura K, Blonski M, Pippin J, Mundel P, Pichler R, Griffin S, Couser WG, Shankland SJ. Activation of a local tissue angiotensin system in podocytes by mechanical strain. Kidney International 65(1):30-39, 2004. 
        6. Durvasula RV, Shankland SJ. Mechanical strain increases SPARC levels in podocytes: implications for glomerulosclerosis. Am J Physiol Renal Physiol 289(3):F577-F584, 2005. 
        7. El Chaar M, Attia E, Chen J, Hannafin J, Poppas DP, Felsen D. Cyclooxygenase-2 inhibitor decreases extracellular matrix synthesis in stretched renal fibroblasts. Nephron Exp Nephrol 100(4):e150-155, 2005.
        8. Giunti S, Pinach S, Arnaldi L, Viberti G, Perin PC, Camussi G, Gruden G. The MCP-1/CCR2 system has direct proinflammatory effects in human mesangial cells. Kidney Int 69(5):856-863, 2006. 
        9. Hegarty NJ, Watson RW, Young LS, O’Neill AJ, Brady HR, Fitzpatrick JM. Cytoprotective effects of nitrates in a cellular model of hydronephrosis. Kidney International 62(1):70-77, 2002. 
        10. Kiley SC, Chevalier RL. Species differences in renal Src activity direct EGF receptor regulation in life or death response to EGF. Am J Physiol Renal Physiol 293(3):F895-F903, 2007. Epub 2007 Jul 11. 
        11. Kiley SC, Thornhill BA, Tang SS, Ingelfinger JR, Chevalier RL. Growth factor-mediated phosphorylation of proapoptotic BAD reduces tubule cell death in vitro and in vivo. Kidney International 63(1):33-42, 2003. 
        12. Maier S, Lutz R, Gelman L, Sarasa-Renedo A, Schenk S, Grashoff C, Chiquet M. Tenascin-C induction by cyclic strain requires integrin-linked kinase. Biochim Biophys Acta 1783(6):1150-1162, 2008. Epub 2008 Jan 26. 
        13. Martineau LC, McVeigh LI, Jasmin BJ, Kennedy CR. p38 MAP kinase mediates mechanically induced COX-2 and PG EP4 receptor expression in podocytes: implications for the actin cytoskeleton. Am J Physiol Renal Physiol 286(4):F693-F701, 2004. 
        14. Miyajima A, Chen J, Lawrence C, Ledbetter S, Soslow RA, Stern J, Jha S, Pigato J, Lemer ML, Poppas DP, Vaughan ED, Felsen D. Antibody to transforming growth factor-β ameliorates tubular apoptosis in unilateral ureteral obstruction. Kidney International 58(6):2301-2313, 2000. 
        15. Miyajima A, Chen J, Poppas DP, Vaughan ED, Felsen D. Role of nitric oxide in renal tubular apoptosis of unilateral ureteral obstruction. Kidney International 59(4):1290-1303, 2001. 
        16. Morgera S, Schlenstedt J, Hambach P, Giessing M, Deger S, Hocher B, Neumayer HH. Combined ETA/ETB receptor blockade of human peritoneal mesothelial cells inhibits collagen I RNA synthesis. Kidney International 64:2033–2040, 2003 
        17. Nguyen HT, Bride SH, Badawy AB, Adam RM, Lin J, Orsola A, Guthrie PD, Freeman MR, Peters CA. Heparin-binding EGF-like growth factor is up-regulated in the obstructed kidney in a cell- and region-specific manner and acts to inhibit apoptosis. American Journal of Pathology 156:889-898, 2000. 
        18. Petermann AT, Hiromura K, Blonski M, Pippin J, Monkawa T, Durvasula R, Couser WG, Shankland SJ. Mechanical stress reduces podocyte proliferation in vitro. Kidney International 61(1):40-50, 2002. 
        19. Petermann AT, Pippin J, Durvasula R, Pichler R, Hiromura K, Monkawa T, Couser WG, Shankland SJ. Mechanical stretch induces podocyte hypertrophy in vitro. Kidney International 67(1):157-166, 2005. 
        20. Ricardo SD, Ding G, Eufemio M, Diamond JR. Antioxidant expression in experimental hydronephrosis: role of mechanical stretch and growth factors. Am J Physiol Renal Physiol 272:F789-F798, 1997. 
        21. Ricardo SD, Franzoni DF, Roesener CD, Crisman JM, Diamond JR. Angiotensinogen and AT(1) antisense inhibition of osteopontin translation in rat proximal tubular cells. Am J Physiol Renal Physiol 278(5):F708-F716, 2000. 
        22. Ryan MJ, Black TA, Gross KW, Hajduczok G. Cyclic mechanical distension regulates renin gene transcription in As4.1 cells. Am J Physiol Endocrinol Metab 279(4):E830-E837, 2000. 
        23. Ryan MJ, Gross KW, Hajduczok G. Calcium-dependent activation of phospholipase C by mechanical distension in renin-expressing As4.1 cells. Am J Physiol Endocrinol Metab 279(4):E823-E829, 2000. 
        24. Sato M, Muragaki Y, Saika S, Roberts AB, Ooshima A. Targeted disruption of TGF-β1/Smad3 signaling protects against renal tubulointerstitial fibrosis induced by unilateral ureteral obstruction. J Clin Invest 112(10):1486-1494, 2003. 
        25. Sussman AN, Sun T, Krofft RM, Durvasula RV. SPARC accelerates disease progression in experimental crescentic glomerulonephritis. Am J Pathol 174(5):1827-1836, 2009. Epub 2009 Mar 26. 
        26. Tanner GA, McQuillan PF, Maxwell MR, Keck JK, McAteer JA. An in vitro test of the cell stretch-proliferation hypothesis of renal cyst enlargement J Am Soc Nephrol 6(4):1230-1241, 1995.

        腎小球膜細胞(Mesangial cells)細胞牽張拉伸應力應用文獻

        27. Akai Y, Homma T, Burns KD, Yasuda T, Badr KF, Harris RC. Mechanical stretch/relaxation of cultured rat mesangial cells induces protooncogenes and cyclooxygenase. Am J Physiol Cell Physiol 267(2):C482-C490, 1994. 
        28. Barutta F, Pinach S, Giunti S, Vittone F, Forbes JM, Chiarle R, Arnstein M, Perin PC, Camussi G, Cooper ME, Gruden G. Heat shock protein expression in diabetic nephropathy. Am J Physiol Renal Physiol 295(6):F1817-F1824, 2008. Epub 2008 Oct 15. 
        29. Clarkson MR, Murphy M, Gupta S, Lambe T, Mackenzie HS, Godson C, Martin F, Brady HR. High glucose-altered gene expression in mesangial cells. Actin-regulatory protein gene expression is triggered by oxidative stress and cytoskeletal disassembly. J Biol Chem 277(12):9707-9712, 2002. 
        30. Cortes P, Zhao X, Riser BL, Narins RG. Role of glomerular mechanical strain in the pathogenesis of diabetic nephropathy.Kidney International 51(1):57-68, 1997. 
        31. Dlugosz JA, Munk S, Kapor-Drezgic J, Goldberg HJ, Fantus IG, Scholey JW, Whiteside CI. Stretch-induced mesangial cell ERK1/ERK2 activation is enhanced in high glucose by decreased dephosphorylation. Am J Physiol Renal Physiol 279:688-697, 2000. 
        32. Gruden G, Araf S, Zonca S, Burt D, Thomas S, Gnudi L, Viberti G. IGF-I induces vascular endothelial growth factor in human mesangial cells via a Src-dependent mechanism. Kidney International 63(4):1249-1255, 2003. 
        33. Gruden G, Setti G, Hayward A, Sugden D, Duggan S, Burt D, Buckingham RE, Gnudi L, Viberti G. Mechanical stretch induces monocyte chemoattractant activity via an NF-κB-dependent monocyte chemoattractant protein-1-mediated pathway in human mesangial cells: inhibition by rosiglitazone. J Am Soc Nephrol 16(3):688-96, 2005. 
        34. Gruden G, Thomas S, Burt D, Lane S, Chusney G, Sacks S, Viberti G. Mechanical stretch induces vascular permeability factor in human mesangial cells: mechanisms of signal transduction. Proc Natl Acad Sci U S A 94(22):12112-12116, 1997. 
        35. Gruden G, Thomas S, Burt D, Zhou W, Chusney G, Gnudi L, Viberti G. Interaction of angiotensin II and mechanical stretch on vascular endothelial growth factor production by human mesangial cells. J Am Soc Nephrol 10(4):730-737, 1999. 
        36. Hayashi Y, Katoh T, Asano K, Onozaki A, Sakurai K, Asahi K, Nakayama M, Watanabe T. Mechanical stretch down-regulates expression of the Smad6 gene in cultured rat mesangial cells. Clin Exp Nephrol 16(5):690-696, 2012. doi: 10.1007/s10157-012-0630-6. Epub 2012 May 12 
        37. Hirakata M, Kaname S, Chung UG, Joki N, Hori Y, Noda M, Takuwa Y, Okazaki T, Fujita T, Katoh T, Kurokawa K. Tyrosine kinase dependent expression of TGF-β induced by stretch in mesangial cells. Kidney Int 51(4):1028-36, 1997. 
        38. Homma T, Akai Y, Burns KD, Harris RC. Activation of S6 kinase by repeated cycles of stretching and relaxation in rat glomerular mesangial cells. Evidence for involvement of protein kinase C. J Biol Chem 267(32):23129-23135, 1992. 
        39. Hori Y, Katoh T, Hirakata M, Joki N, Kaname S, Fukagawa M, Okuda T, Ohashi H, Fujita T, Miyazono K, Kurokawa K.Anti-latent TGF- binding protein-1 antibody or synthetic oligopeptides inhibit extracellular matrix expression induced by stretch in cultured rat mesangial cells. Kidney Int 53:1616-1625, 1998. 
        40. Ingram AJ, James L, Cai L, Thai K, Ly H, Scholey JW. NO inhibits stretch-induced MAPK activity by cytoskeletal disruption. J Biol Chem 275(51):40301-40306, 2000. 
        41. Ingram AJ, James L, Ly H, Thai K, Cai L, Scholey JW. Nitric oxide modulates stretch activation of mitogen-activated protein kinases in mesangial cells. Kidney International 58(3):1067-1077, 2000. 
        42. Ingram AJ, James L, Ly H, Thai K, Scholey JW. Stretch activation of Jun N-terminal kinase/stress-activated protein kinase in mesangial cells. Kidney International 58(4):1431-1439, 2000. 
        43. Ingram AJ, James L, Thai K, Ly H, Cai L, Scholey JW. Nitric oxide modulates mechanical strain-induced activation of p38 MAPK in mesangial cells. Am J Physiol Renal Physiol 279(2):F243-F251, 2000. 
        44. Ingram AJ, Ly H, Thai K, Kang M, Scholey JW. Activation of mesangial cell signaling cascades in response to mechanical strain. Kidney International 55(2):476-485, 1999. 
        45. Ingram AJ, Ly H, Thai K, Kang MJ, Scholey JW. Mesangial cell signaling cascades in response to mechanical strain and glucose.Kidney International 56(5):1721-1728, 1999. 
        46. Krepinsky J, Ingram AJ, James L, Ly H, Thai K, Cattran DC, Miller JA, Scholey JW. 17β-Estradiol modulates mechanical strain-induced MAPK activation in mesangial cells. J Biol Chem 277(11):9387-9394, 2002. 
        47. Krepinsky JC, Ingram AJ, Tang D, Wu D, Liu L, Scholey JW. Nitric oxide inhibits stretch-induced MAPK activation in mesangial cells through RhoA inactivation. J Am Soc Nephrol 14(11):2790-2800, 2003. 
        48. Krepinsky JC, Li Y, Chang Y, Liu L, Peng F, Wu D, Tang D, Scholey J, Ingram AJ. Akt mediates mechanical strain-induced collagen production by mesangial cells. J Am Soc Nephrol 16(6):1661-1672, 2005. 
        49. McMahon R, Murphy M, Clarkson M, Taal M, Mackenzie HS, Godson C, Martin F, Brady HR. IHG-2, a mesangial cell gene induced by high glucose, is human gremlin. Regulation by extracellular glucose concentration, cyclic mechanical strain, and transforming growth factor-b1. J Biol Chem 275(14):9901-9904, 2000. 
        50. Peng F, Wu D, Ingram AJ, Zhang B, Gao B, Krepinsky JC. RhoA activation in mesangial cells by mechanical strain depends on caveolae and caveolin-1 interaction. J Am Soc Nephrol 18(1):189-198, 2007. Epub 2006 Nov 22. 
        51. Riser BL, Cortes P, Yee J, Sharba AK, Asano K, Rodriguez-Barbero A, Narins RG. Mechanical strain- and high glucose-induced alterations in mesangial cell collagen metabolism: role of TGF-β. J Am Soc Nephrol 9:827-836, 1998. 
        52. Riser BL, Denichilo M, Cortes P, Baker C, Grondin JM, Yee J, Narins RG. Regulation of connective tissue growth factor activity in cultured rat mesangial cells and its expression in experimental diabetic glomerulosclerosis. J Am Soc Nephrol 11(1):25-38, 2000. 
        53. Riser BL, Ladson-Wofford S, Sharba A, Cortes P, Drake K, Guerin CJ, Yee J, Choi ME, Segarini PR, Narins RG. TGF-β receptor expression and binding in rat mesangial cells: Modulation by glucose and cyclic mechanical strain. Kidney International56(2):428-439, 1999. 
        54. Riser BL, Varani J, Cortes P, Yee J, Dame M, Sharba AK. Cyclic stretching of mesangial cells up-regulates intercellular adhesion molecule-1 and leukocyte adherence: a possible new mechanism for glomerulosclerosis. Am J Pathol 158(1):11-17, 2001. 
        55. Yasuda T, Kondo S, Homma T, Harris RC. Regulation of extracellular matrix by mechanical stress in rat glomerular mesangial cells. J Clin Invest 98(9):1991-2000, 1996. 
        56. Yasuda T, Kondo S, Owada S, Ishida M, Harris RC. Integrins and the cytoskeleton: focal adhesion kinase and paxillin. Nephrol Dial Transplant 14(Suppl 1):58-60, 1999. 
        57. Yatabe J, Sanada H, Yatabe MS, Hashimoto S, Yoneda M, Felder RA, Jose PA, Watanabe T. Angiotensin II type 1 receptor blocker attenuates the activation of ERK and NADPH oxidase by mechanical strain in mesangial cells in the absence of angiotensin II. Am J Physiol Renal Physiol 296(5):F1052-F1060, 2009. Epub 2009 Mar 4.

        腎小管上皮細胞(Renal epithelial cells)細胞牽張拉伸應力應用文獻

        58. Cachat F, Lange-Sperandio B, Chang AY, Kiley SC, Thornhill BA, Forbes MS, Chevalier RL. Ureteral obstruction in neonatal mice elicits segment-specific tubular cell responses leading to nephron loss. Kidney International 63(2):564-575, 2003. 
        59. Kiley SC, Thornhill BA, Belyea BC, Neale K, Forbes MS, Luetteke NC, Lee DC, Chevalier RL. Epidermal growth factor potentiates renal cell death in hydronephrotic neonatal mice, but cell survival in rats. Kidney International 68(2):504-514, 2005. 
        60. Nguyen HT, Hsieh MH, Gaborro A, Tinloy B, Phillips C, Adam RM. JNK/SAPK and p38 SAPK-2 mediate mechanical stretch-induced apoptosis via caspase-3 and -9 in NRK-52E renal epithelial cells. Nephron Exp Nephrol 102(2):e49-61, 2006. 
        61. Power RE, Doyle BT, Higgins D, Brady HR, Fitzpatrick JM, Watson RW. Mechanical deformation induced apoptosis in human proximal renal tubular epithelial cells is caspase dependent. J Urol 171(1):457-61, 2004. 
        62. Sato M, Muragaki Y, Saika S, Roberts AB, Ooshima A. Targeted disruption of TGF- β1/Smad3 signaling protects against renal tubulointerstitial fibrosis induced by unilateral ureteral obstruction. J Clin Invest 112(10):1486-1494, 2003.

        韌帶(Ligament)細胞牽張拉伸應力應用文獻

        牙周膜(Periodontal ligament)細胞牽張拉伸應力應用文獻

        1. Agarwal S, Long P, Seyedain A, Piesco N, Shree A, Gassner R. A central role for the nuclear factor-κB pathway in anti-inflammatory and proinflammatory actions of mechanical strain. FASEB J 17(8):899-901, 2003. Epub 2003 Mar 28. 
        2. Bolcato-Bellemin AL, Elkaim R, Abehsera A, Fausser JL, Haikel H, Tenenbaum H. Expression of mRNAs encoding for a and B integrin subunits, MMPs, and TIMPs in stretched human periodontal ligament and gingival fibroblasts. J Dent Res 79(9):1712-1716, 2000. 
        3. Chiba M, Mitani H. Cytoskeletal changes and the system of regulation of alkaline phosphatase activity in human periodontal ligament cells induced by mechanical stress. Cell Biochemistry and Function 22(4):249-256, 2004. 
        4. Cho JH, Lee SK, Lee JW, Kim EC. The role of heme oxygenase-1 in mechanical stress- and lipopolysaccharide-induced osteogenic differentiation in human periodontal ligament cells. Angle Orthod 80(4):552-559, 2010. 
        5. Doi T, Ohno S, Tanimoto K, Honda K, Tanaka N, Ohno-Nakahara M, Yoneno K, Suzuki A, Nakatani Y, Ueki M, Tanne K.Mechanical stimuli enhances the expression of RGD-CAP/β ig-h3 in the periodontal ligament. Archives of Oral Biology 48(8):573-579, 2003. 
        6. Duarte WR, Mikuni-Takagaki Y, Kawase T, Limura T, Oida S, Ohya K, Takenaga K, Ishikawa L, Kasugai S. Effects of mechanical stress on the mRNA expression of S100A4 and cytoskeletal components by periodontal ligament cells. J Med Dent Sci 46(3):117-122, 1999. 
        7. Enokiya Y, Hashimoto S, Muramatsu T, Jung HS, Tazaki M, Inoue T, Abiko Y, Shimono M. Effect of stretching stress on gene transcription related to early-phase differentiation in rat periodontal ligament cells. Bull Tokyo Dent Coll 51(3):129-137, 2010. 
        8. Han Y, Pan J, Wang X, Qi Y, Wang S, Yan Z. Cyclic strain promotes migration and proliferation of human periodontal ligament cell via PI3K signaling pathway. Cellular and Molecular Bioengineering 3(4): 369-375, 2010. 
        9. Kanzaki H, Chiba M, Sato A, Miyagawa A, Arai K, Nukatsuka S, Mitani H. Cyclical tensile force on periodontal ligament cells inhibits osteoclastogenesis through OPG induction. J Dent Res 85(5):457-462, 2006. 
        10. Kikuiri T, Hasegawa T, Yoshimura Y, Shirakawa T, Oguchi H. Cyclic tension force activates nitric oxide production in cultured human periodontal ligament cells. J Periodontol 71(4):533-539, 2000. 
        11. Kim HJ, Choi YS, Jeong MJ, KimBO, Lim SH, Kim DK, Kim CK, Park JC. Expression of UNCL during development of periodontal tissue and response of periodontal ligament fibroblasts to mechanical stress in vivo and in vitro. Cell Tissue Res 327(1):25-31, 2007. 
        12. Kimoto S, Matsuzawa M, Matsubara S, Komatsu T, Uchimura N, Kawase T, Saito S. Cytokine secretion of periodontal ligament fibroblasts derived from human deciduous teeth: effect of mechanical stress on the secretion of transforming growth factor-β1 and macrophage colony stimulating factor. J Periodontal Res 34(5):235-243, 1999. 
        13. Liu M, Dai J, Lin Y, Yang L, Dong H, Li Y, Ding Y, Duan Y. Effect of the cyclic stretch on the expression of osteogenesis genes in human periodontal ligament cells. Gene 491(2):187-193, 2012. Epub 2011 Oct 12. 
        14. Long P, Hu J, Piesco N, Buckley M, Agarwal S. Low magnitude of tensile strain inhibits IL-1β-dependent induction of pro-inflammatory cytokines and induces synthesis of IL-10 in human periodontal ligament cells in vitro. J Dent Res 80(5):1416-1420, 2001. 
        15. Long P, Liu F, Piesco NP, Kapur R, Agarwal S. Signaling by mechanical strain involves transcriptional regulation of proinflammatory genes in human periodontal ligament cells in vitro. Bone 30(4):547-552, 2002. 
        16. Matsuda N, Yokoyama K, Takeshita S, Watanabe M. Role of epidermal growth factor and its receptor in mechanical stress-induced differentiation of human periodontal ligament cells in vitro. Arch Oral Biol 43(12):987-997, 1998. 
        17. Miura S, Yamaguchi M, Shimizu N, Abiko Y. Mechanical stress enhances expression and production of plasminogen activator in aging human periodontal ligament cells. Mechanisms of Ageing and Development 112(3):217-231, 2000.
        18. Myokai F, Oyama M, Nishimura F, Ohira T, Yamamoto T, Arai H, Takashiba S, Murayama Y. Unique genes induced by mechanical stress in periodontal ligament cells. J Periodontal Res 38(3):255-261, 2003. 
        19. Nokhbehsaim M, Deschner B, Winter J, Bourauel C, Jger A, Jepsen S, Deschner J. Anti-inflammatory effects of EMD in the presence of biomechanical loading and interleukin-1β in vitro. Clin Oral Investig 16(1):275-283, 2012. Epub 2011 Jan 12.

        20. Nokhbehsaim M, Deschner B, Winter J, Bourauel C, Rath B, Jger A, Jepsen

        S, Deschner J. Interactions of regenerative, inflammatory and biomechanical signals on bone morphogenetic protein-2 in periodontal ligament cells. J Periodontal Res 46(3):374-381, 2011. doi: 10.1111/j.1600-0765.2011.01357.x. Epub 2011 Mar 17. 
        21. Nokhbehsaim M, Deschner B, Winter J, Reimann S, Bourauel C, Jepsen S, Jger A, Deschner J. Contribution of orthodontic load to inflammation-mediated periodontal destruction. J Orofac Orthop 71(6):390-402, 2010. Epub 2010 Nov 17. 
        22. Ohzeki K, Yamaguchi M, Shimizu N, Abiko Y. Effect of cellular aging on the induction of cyclooxygenase-2 by mechanical stress in human periodontal ligament cells. Mechanisms of Ageing and Development 108(2):151-163, 1999.
        23. Ozaki S, Kaneko S, Podyma-Inoue KA, Yanagishita M, Soma K. Modulation of extracellular matrix synthesis and alkaline phosphatase activity of periodontal ligament cells by mechanical stress. J Periodontal Res 40(2):110-117, 2005. 
        24. Ozawa Y, Shimizu N, Abiko Y. Low-energy diode laser irradiation reduced plasminogen activator activity in human periodontal ligament cells. Lasers Surg Med 21(5):456-463, 1997. 
        25. Saeki Y, Ohara A, Nishikawa M, Yamamoto T, Yamamoto G. The presence of arachidonic acid-activated K+ channel, TREK-1, in human periodontal ligament fibroblasts. Drug Metab Rev 39(2-3):457-465, 2007. 
        26. Saminathan A, Vinoth KJ, Wescott DC, Pinkerton MN, Milne TJ, Cao T, Meikle MC. The effect of cyclic mechanical strain on the expression of adhesion-related genes by periodontal ligament cells in two-dimensional culture. J Periodontal Res 47(2):212-221, 2012. doi: 10.1111/j.1600-0765.2011.01423.x. Epub 2011 Oct 20.
        27. Shimizu N, Yamaguchi M, Uesu K, Goseki T, Abiko Y. Stimulation of prostaglandin E2 and interleukin-1βproduction from old rat periodontal ligament cells subjected to mechanical stress. J Gerontol A Biol Sci Med Sci 55(10):B489-B495, 2000. 
        28. Tsuji K, Uno K, Zhang GX, Tamura M. Periodontal ligament cells under intermittent tensile stress regulate mRNA expression of osteoprotegerin and tissue inhibitor of matrix metalloprotease-1 and -2. J Bone Miner Metab 22(2):94-103, 2004. 
        29. Wen W, Chau E, Jackson-Boeters L, Elliott C, Daley TD, Hamilton DW. TGF-1 and FAK regulate periostin expression in PDL fibroblasts. J Dent Res 89(12):1439-1443, 2010. Epub 2010 Oct 12. 
        30.Wescott DC, Pinkerton MN, Gaffey BJ, Beggs KT, Milne TJ, Meikle MC. Osteogenic gene expression by human periodontal ligament cells under cyclic tension. J Dent Res 86(12):1212-1216, 2007. 
        31. Yamaguchi M, Shimizu N, Goseki T, Shibata Y, Takiguchi H, Iwasawa T, Abiko Y. Effect of different magnitudes of tension force on prostaglandin E"2 production by human periodontal ligament cells. Archives of Oral Biology 39(10):877-884, 1994. 
        32. Yamaguchi M, Shimizu N, Ozawa Y, Saito K, Miura S, Takiguchi H, Iwasawa T, Abiko Y. Effect of tension-force on plasminogen activator activity from human periodontal ligament cells. J Periodontal Res 32(3):308-314, 1997. 
        33. Yamaguchi M, Shimizu N. Identification of factors mediating the decrease of alkaline phosphatase activity caused by tension-force in periodontal ligament cells. General Pharmacology 25(6):1229-1235, 1994. 
        34. Yamaguchi N, Chiba M, Mitani H. The induction of c-fos mRNA expression by mechanical stress in human periodontal ligament cells. Archives of Oral Biology 47(6):465-471, 2002. 
        5. Yamashiro K, Myokai F, Hiratsuka K, Yamamoto T, Senoo K, Arai H, Nishimura F, Abiko Y, Takashiba S. Oligonucleotide array analysis of cyclic tension-responsive genes in human periodontal ligament fibroblasts. The International Journal of Biochemistry & Cell Biology 39(5):910-921, 2007. 
        36. Yoshino H, Morita I, Murota SI, Ishikawa I. Mechanical stress induces production of angiogenic regulators in cultured human gingival and periodontal ligament fibroblasts. J Periodontal Res 38(4):405-410, 2003.

        膝關節韌帶(Knee ligaments)細胞牽張拉伸應力應用文獻

        37. Hannafin JA, Attia EA, Henshaw R, Warren RF, Bhargava MM. Effect of cyclic strain and plating matrix on cell proliferation and integrin expression by ligament fibroblasts. J Orthop Res 24(2):149-58, 2005. 
        38. Henshaw DR, Attia E, Bhargava M, Hannafin JA. Canine ACL fibroblast integrin expression and cell alignment in response to cyclic tensile strain in three-dimensional collagen gels. J Orthop Res 24(3):481-490, 2006. 
        39. Hsieh AH, Tsai CM, Ma QJ, Lin T, Banes AJ, Villarreal FJ, Akeson WH, Sung KL. Time-dependent increases in type-III collagen gene expression in medical collateral ligament fibroblasts under cyclic strains. J Orthop Res 18(2):220-227, 2000. 
        40. Jones BF, Wall ME, Carroll RL, Washburn S, Banes AJ. Ligament cells stretch-adapted on a microgrooved substrate increase intercellular communication in response to a mechanical stimulus. J Biomech 38(8):1653-1664, 2005. 
        41. Lee CH, Shin HJ, Cho IH, Kang YM, Kim IA, Park KD, Shin JW. Nanofiber alignment and direction of mechanical strain affect the ECM production of human ACL fibroblast. Biomaterials 26(11):1261-1270, 2005. 
        42. Lee CY, Liu X, Smith CL, Zhang X, Hsu HC, Wang DY, Luo ZP. The combined regulation of estrogen and cyclic tension on fibroblast biosynthesis derived from anterior cruciate. Matrix Biology 23(5):323-329, 2004. 
        43. Lee CY, Smith CL, Zhang X, Hsu HC, Wang DY, Luo ZP. Tensile forces attenuate estrogen-stimulated collagen synthesis in the ACL. Biochemical and Biophysical Research Communications 317:1221–1225, 2004.

        其他韌帶細胞(Other ligament cells)細胞牽張拉伸應力應用文獻

        44. Ewies AA, Elshafie M, Li J, Stanley A, Thompson J, Styles J, White I, Al-Azzawi F. Changes in transcription profile and cytoskeleton morphology in pelvic ligament fibroblasts in response to stretch: the effects of estradiol and levormeloxifene. Mol Hum Reprod 14(2):127-135, 2008. Epub 2008 Jan 9. 
        45. Nakatani T, Marui T, Hitora T, Doita M, Nishida K, Kurosaka M. Mechanical stretching force promotes collagen synthesis by cultured cells from human ligamentum flavum via transforming growth factor-1. J Orthop Res 20(6):1380-1386, 2002. 
        46. Yang HS, Lu XH, Chen DY, Yuan W, Yang LL, Chen Y, He HL. Mechanical strain induces Cx43 expression in spinal ligament fibroblasts derived from patients presenting ossification of the posterior longitudinal ligament. Eur Spine J 20(9):1459-1465, 2011. Epub 2011 Mar 26.

        肝臟(Liver)細胞牽張拉伸應力應用文獻

        1. Amura CR, Brodsky KS, Gitomer B, McFann K, Lazennec G, Nichols MT, Jani A, Schrier RW, Doctor RB. CXCR2 agonists in ADPKD liver cyst fluids promote cell proliferation. Am J Physiol Cell Physiol 294(3):C786-C796, 2008. Epub 2008 Jan 16. 
        2. Sakata R, Ueno T, Nakamura T, Ueno H, Sata M. Mechanical stretch induces TGF-β synthesis in hepatic stellate cells. Eur J Clin Invest 34(2):129-136, 2004.

        肺(Lung)細胞牽張拉伸應力應用文獻

        肺泡巨噬細胞(Alveolar macrophages)細胞牽張拉伸應力應用文獻

        1. Edwards YS, Sutherland LM, Murray AW. NO protects alveolar type II cells from stretch-induced apoptosis. A novel role for macrophages in the lung. Am J Physiol Lung Cell Mol Physiol 279(6):L1236-L1242, 2000. 
        2. Frank JA, Wray CM, McAuley DF, Schwendener R, Matthay MA. Alveolar macrophages contribute to alveolar barrier dysfunction in ventilator-induced lung injury. Am J Physiol Lung Cell Mol Physiol 291(6):L1191-8, 2006.

        肺成纖維細胞(Lung fibroblasts)細胞牽張拉伸應力應用文獻

        3. Aljamal-Naylor R, Wilson L, McIntyre S, Rossi F, Harrison B, Marsden M, Harrison DJ. Allosteric modulation of beta1 integrin function induces lung tissue repair. Adv Pharmacol Sci 2012:768720, 2012. Epub 2012 Feb 26. 
        4. Breen EC, Fu Z, Norman H. Calcyclin gene expression is increased by mechanical strain in fibroblasts and lung. Am J Respir Cell Mol Biol 21:746–752, 1999. 
        5. Breen EC. Mechanical strain increases type I collagen expression in pulmonary fibroblasts in vitro. J Appl Physiol 88(1):203-209, 2000. 
        6. Blaauboer ME, Smit TH, Hanemaaijer R, Stoop R, Everts V. Cyclic mechanical stretch reduces myofibroblast differentiation of primary lung fibroblasts. Biochem Biophys Res Commun 404(1):23-27, 2011. Epub 2010 Nov 20. 
        7. Copland IB, Reynaud D, Pace-Asciak C, Post M. Mechanotransduction of stretch-induced prostanoid release by fetal lung epithelial cells. Am J Physiol Lung Cell Mol Physiol 291(3):L487-L495, 2006. 
        8. Klein G, Schaefer A, Hilfiker-Kleiner D, Oppermann D, Shukla P, Quint A, Podewski E, Hilfiker A, Schroder F, Leitges M, Drexler H. Increased collagen deposition and diastolic dysfunction but preserved myocardial hypertrophy after pressure overload in mice lacking PKCε. Circ Res 96(7):748-755, 2005. 
        9. Le Bellego F, Plante S, Chakir J, Hamid Q, Ludwig MS. Differences in MAP kinase phosphorylation in response to mechanical strain in asthmatic fibroblasts. Respir Res 7:68, 2006. 
        10. Sanchez-Esteban J, Wang Y, Cicchiello LA, Rubin LP. Pre- and postnatal lung development, maturation, and plasticity. Cyclic mechanical stretch inhibits cell proliferation and induces apoptosis in fetal rat lung fibroblasts. Am J Physiol Lung Cell Mol Physiol282(3):L448-L456, 2002.

        間皮細胞(Mesothelial cells)細胞牽張拉伸應力應用文獻

        11. Brown SC, Kamal M, Nasreen N, Baumuratov A, Sharma P, Antony VB, Moudgil BM. Influence of shape, adhesion and simulated lung mechanics on amorphous silica nanoparticle toxicity. Adv Powder Tech 18(1):69-79, 2007.
        12. Waters CM, Chang JY, Glucksberg MR, DePaola N, Grotberg JB. Mechanical forces alter growth factor release by pleural mesothelial cells. Am J Physiol 272(3 Pt 1):L552-L557, 1997.

        肺動脈內皮細胞(Pulmonary endothelial cells)細胞牽張拉伸應力應用文獻

        13. Abdulnour RE, Peng X, Finigan JH, Han EJ, Hasan EJ, Birukov KG, Reddy SP, Watkins JE 3rd, Kayyali US, Garcia JG, Tuder RM, Hassoun PM. Mechanical stress activates xanthine oxidoreductase through MAP kinase-dependent pathways. Am J Physiol Lung Cell Mol Physiol 291(3):L345-L353, 2006. 
        14. Ali MH, Mungai PT, Schumacker PT. Stretch-induced phosphorylation of focal adhesion kinase in endothelial cells: role of mitochondrial oxidants. Am J Physiol Lung Cell Mol Physiol 291(1):L38-L45, 2006. 
        15. Birukov KG, Jacobson JR, Flores AA, Ye SQ, Birukova AA, Verin AD, Garcia JG. Magnitude-dependent regulation of pulmonary endothelial cell barrier function by cyclic stretch. Am J Physiol Lung Cell Mol Physiol 285(4):L785-L797, 2003.
        16. Birukova AA, Chatchavalvanich S, Rios A, Kawkitinarong K, Garcia JG, Birukov KG. Differential regulation of pulmonary endothelial monolayer integrity by varying degrees of cyclic stretch. Am J Pathol 168(5):1749-1761, 2006. 
        17. Birukova AA, Fu P, Xing J, Cokic I, Birukov KG. Lung endothelial barrier protection by iloprost in the 2-hit models of ventilator-induced lung injury (VILI) involves inhibition of Rho signaling. Transl Res 155(1):44-54, 2010. 
        18. Birukova AA, Fu P, Xing J, Yakubov B, Cokic I, Birukov KG. Mechanotransduction by GEF-H1 as a novel mechanism of ventilator-induced vascular endothelial permeability. Am J Physiol Lung Cell Mol Physiol 298(6):L837-848, 2010. Epub 2010 Mar 26. 
        19. Birukova AA, Moldobaeva N, Xing J, Birukov KG. Magnitude-dependent effects of cyclic stretch on HGF- and VEGF-induced pulmonary endothelial remodeling and barrier regulation. Am J Physiol Lung Cell Mol Physiol 295(4):L612-L623, 2008. Epub 2008 Aug 8. 
        20. Birukova AA, Rios A, Birukov KG. Long-term cyclic stretch controls pulmonary endothelial permeability at translational and post-translational levels. Exp Cell Res 314(19):3466-3477, 2008. Epub 2008 Sep 19. 
        21. Haseneen NA, Vaday GG, Zucker S, Foda HD. Mechanical stretch induces MMP-2 release and activation in lung endothelium: role of EMMPRIN. Am J Physiol Lung Cell Mol Physiol 284(3):L541-L547, 2003. 
        22. Grigoryev DN, Ma SF, Irizarry RA, Ye SQ, Quackenbush J, Garcia JG. Orthologous gene-expression profiling in multi-species models: search for candidate genes. Genome Biol 5(5):R34, 2004. Epub 2004 Apr 27. 
        23. Liu WF, Nelson CM, Tan JL, Chen CS. Cadherins, RhoA, and Rac1 are differentially required for stretch-mediated proliferation in endothelial versus smooth muscle cells. Circ Res 101(5):e44-e52, 2007. Epub 2007 Aug 21. 
        24. Nonas S, Birukova AA, Fu P, Xing J, Chatchavalvanich S, Bochkov VN, Leitinger N, Garcia JG, Birukov KG. Oxidized phospholipids reduce ventilator-induced vascular leak and inflammation in vivo. Crit Care 12(1):R27, 2008. Epub 2008 Jan 24. 
        25. Shikata Y, Rios A, Kawkitinarong K, DePaola N, Garcia JG, Birukov KG. Differential effects of shear stress and cyclic stretch on focal adhesion remodeling, site-specific FAK phosphorylation, and small GTPases in human lung endothelial cell. Experimental Cell Research 304(1):40-49, 2005. 
        26. Wedgwood S, Devol JM, Grobe A, Benavidez E, Azakie A, Fineman JR, Black SM. Fibroblast growth factor-2 expression is altered in lambs with increased pulmonary blood flow and pulmonary hypertension. Pediatr Res 61(1):32-36, 2007.

        肺上皮細胞(Pulmonary epithelial cells)細胞牽張拉伸應力應用文獻

        27. Budinger GR, Urich D, DeBiase PJ, Chiarella SE, Burgess ZO, Baker CM, Soberanes S, Mutlu GM, Jones JC. Stretch-induced activation of AMP kinase in the lung requires dystroglycan. Am J Respir Cell Mol Biol 39(6):666-672, 2008. Epub 2008 Jun 12. 
        28. Chapman KE, Sinclair SE, Zhuang D, Hassid A, Desai LP, Waters CM. Cyclic mechanical strain increases reactive oxygen species production in pulmonary epithelial cells. Am J Physiol Lung Cell Mol Physiol 289(5):L834-L841, 2005.
        29. Charles PE, Tissières P, Barbar SD, Croisier D, Dufour J, Dunn-Siegrist I, Chavanet P, Pugin J. Mild-stretch mechanical ventilation upregulates toll-like receptor 2 and sensitizes the lung to bacterial lipopeptide. Crit Care 15(4):R181, 2011. 
        30. Chaturvedi LS, Marsh HM, Basson MD. Src and focal adhesion kinase mediate mechanical strain-induced proliferation and ERK1/2 phosphorylation in human H441 pulmonary epithelial cells. Am J Physiol Cell Physiol 292(5):C1701-C1713, 2007. Epub 2007 Jan 10. 
        31. Chess PR, O’Reilly MA, Sachs F, Finkelstein JN. Reactive oxidant and p42/44 MAP kinase signaling is necessary for mechanical strain-induced proliferation in pulmonary epithelial cells. J Appl Physiol 99(3):1226-1232, 2005. 
        32. Chess PR, O’Reilly MA, Toia L. Macroarray analysis reveals a strain-induced oxidant response in pulmonary epithelial cells. Exp Lung Res 30(8):739-53, 2004. 
        33. Chess PR, Toia L, Finkelstein JN. Mechanical strain-induced proliferation and signaling in pulmonary epithelial H441 cells. Am J Physiol Lung Cell Mol Physiol 279:L43-L51, 2000. 
        34. Copland IB, Post M. Stretch-activated signaling pathways responsible for early response gene expression in fetal lung epithelial cells. J Cell Physiol 210(1):133-143, 2007. 
        35. Copland IB, Reynaud D, Pace-Asciak C, Post M. Mechanotransduction of stretch-induced prostanoid release by fetal lung epithelial cells. Am J Physiol Lung Cell Mol Physiol 291(3):L487-L495, 2006. 
        36. Correa-Meyer E, Pesce L, Guerrero C, Sznajder JI. Cyclic stretch activates ERK1/2 via G proteins and EGFR in alveolar epithelial cells. Am J Physiol Lung Cell Mol Physiol 282(5):L883-L891, 2002. 
        37. Desai LP, Chapman KE, Waters CM. Mechanical stretch decreases migration of alveolar epithelial cells through mechanisms involving Rac1 and Tiam1. Am J Physiol Lung Cell Mol Physiol 295(5):L958-L965, 2008. Epub 2008 Sep 19. 
        38. Desai LP, White SR, Waters CM. Mechanical stretch decreases FAK phosphorylation and reduces cell migration through loss of JIP3-induced JNK phosphorylation in airway epithelial cells. Am J Physiol Lung Cell Mol Physiol 297(3):L520-L529, 2009. Epub 2009 Jul 2.
        39. Desai LP, White SR, Waters CM. Cyclic mechanical stretch decreases cell migration by inhibiting phosphatidylinositol 3-kinase- and focal adhesion kinase-mediated JNK1 activation. J Biol Chem 285(7):4511-4519, 2010. Epub 2009 Dec 14. 
        40. Ding N, Xiao H, Xu LX, She SZ. Effect of mitogen-activated protein kinase kinase 6-p38α signal pathway on receptor for advanced glycation end-product expression in alveolar epithelial cells induced by mechanical stretch. Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 21(10):597-600, 2009. 
        41. dos Santos CC, Han B, Andrade CF, Bai X, Uhlig S, Hubmayr R, Tsang M, Lodyga M, Keshavjee S, Slutsky AS, Liu M. DNA microarray analysis of gene expression in alveolar epithelial cells in response to TNFα, LPS, and cyclic stretch. Physiol Genomics19(3):331-342, 2004. 
        42. Eckle T, Fullbier L, Wehrmann M, Khoury J, Mittelbronn M, Ibla J, Rosenberger P, Eltzschig HK. Identification of ectonucleotidases CD39 and CD73 in innate protection during acute lung injury. The Journal of Immunology 178:8127-8137, 2007.
        43. Edwards YS, Sutherland LM, Murray AW. NO protects alveolar type II cells from stretch-induced apoptosis. A novel role for macrophages in the lung. Am J Physiol Lung Cell Mol Physiol 279(6):L1236-L1242, 2000. 
        44. Edwards YS, Sutherland LM, Power JHT, Nicholas TE, Murray AW. Cyclic stretch induces both apoptosis and secretion in rat alveolar type II cells. FEBS Letters 448(1):127-130, 1999. 
        45. Frank JA, Wray CM, McAuley DF, Schwendener R, Matthay MA. Alveolar macrophages contribute to alveolar barrier dysfunction in ventilator-induced lung injury. Am J Physiol Lung Cell Mol Physiol 291(6):L1191-8, 2006. 
        46. Geiger RC, Kaufman CD, Lam AP, Budinger GR, Dean DA. Tubulin acetylation and histone deacetylase 6 activity in the lung under cyclic load. Am J Respir Cell Mol Biol 40(1):76-82, 2009. Epub 2008 Jul 17. 
        47. Gutierrez JA, Suzara VV, Dobbs LG. Continuous mechanical contraction modulates expression of alveolar epithelial cell phenotype. American Journal of Respiratory Cell and Molecular Biology 29:81-87, 2003. 
        48. Hammerschmidt S, Kuhn H, Grasenack T, Gessner C, Wirtz H. Apoptosis and necrosis induced by cyclic mechanical stretching in alveolar type II cells. Am J Respir Cell Mol Biol 30(3):396-402, 2004. 
        49. Hammerschmidt S, Kuhn H, Sack U, Schlenska A, Gessner C, Gillissen A, Wirtz H. Mechanical stretch alters alveolar type II cell mediator release toward a proinflammatory pattern. Am J Respir Cell Mol Biol 33(2):203-210, 2005. Epub 2005 Jun 9. 
        50. Hossain MM, Smith PG, Wu K, Jin JP. Cytoskeletal tension regulates both expression and degradation of h2-calponin in lung alveolar cells. Biochemistry 45(51):15670-15683, 2006. 
        51. Huang Z, Wang Y, Nayak PS, Dammann CE, Sanchez-Esteban J. Stretch-induced fetal type II cell differentiation is mediated via ErbB1 - ErbB4 interactions. J Biol Chem 287(22):18091-18102, 2012. Epub 2012 Apr 9. 
        52. Jones JC, Lane K, Hopkinson SB, Lecuona E, Geiger RC, Dean DA, Correa-Meyer E, Gonzales M, Campbell K, Sznajder JI, Budinger S. Laminin-6 assembles into multimolecular fibrillar complexes with perlecan and participates in mechanical-signal transduction via a dystroglycan-dependent, integrin-independent mechanism. J Cell Sci 118(Pt 12):2557-2566, 2005. 
        53. Kim KC, Zheng QX, Brody JS. Effect of floating a gel matrix on mucin release in cultured airway epithelial cells. J Cell Physiol156(3):480-486, 1993. 
        54. Lee HS, Wang Y, Maciejewski BS, Esho K, Fulton C, Sharma S, Sanchez-Esteban J. Interleukin-10 protects cultured fetal rat type II epithelial cells from injury induced by mechanical stretch. Am J Physiol Lung Cell Mol Physiol 294:L225–L232, 2008. 
        55. Makena PS, Luellen CL, Balazs L, Ghosh MC, Parthasarathi K, Waters CM, Sinclair SE. Preexposure to hyperoxia causes increased lung injury and epithelial apoptosis in mice ventilated with high tidal volumes. Am J Physiol Lung Cell Mol Physiol299(5):L711-L719, 2010. Epub 2010 Sep 10. 
        56. McAdams RM, Mustafa SB, Shenberger JS, Dixon PS, Henson BM, DiGeronimo RJ. Cyclic stretch attenuates effects of hyperoxia on cell proliferation and viability in human alveolar epithelial cells. Am J Physiol Lung Cell Mol Physiol 291(2):L166-74, 2006. 
        57. Mohammed KA, Nasreen N, Tepper RS, Antony VB. Cyclic stretch induces PlGF expression in bronchial airway epithelial cells via nitric oxide release. Am J Physiol Lung Cell Mol Physiol 292(2):L559-L566, 2007. 
        58. Ning Q, Wang X. Role of Rel A and IκB of nuclear factor κB in the release of interleukin-8 by cyclic mechanical strain in human alveolar type II epithelial cells A549. Respirology 12(6):792-798, 2007. 
        59. Oudin S, Pugin J. Role of MAP kinase activation in interleukin-8 production by human BEAS-2B bronchial epithelial cells submitted to cyclic stretch. Am J Respir Cell Mol Biol 27(1):107-14, 2002. 
        60. Papaiahgari S, Yerrapureddy A, Hassoun PM, Garcia JG, Birukov KG, Reddy SP. EGFR-activated signaling and actin remodeling regulate cyclic stretch-induced NRF2-ARE activation. Am J Respir Cell Mol Biol 36(3):304-312, 2007. Epub 2006 Sep 28. 
        61. Pasternack M Jr, Liu X, Goodman RA, Rannels DE. Regulated stimulation of epithelial cell DNA synthesis by fibroblast-derived mediators. Am J Physiol 272(4 Pt 1):L619-L630, 1997. 
        62. Patel H, Eo S, Kwon S. Effects of diesel particulate matters on inflammatory responses in static and dynamic culture of human alveolar epithelial cells. Toxicol Lett 200(1-2):124-131, 2011. Epub 2010 Nov 19. 
        63. Patel H, Kim H, Kwon S. Effect of dynamic environment on the interaction between nanoparticles and human airway epithelial cell monolayer. NSTI-Nanotech 3:565-568, 2010. 
        64. Rose F, Zwick K, Ghofrani HA, Sibelius U, Seeger W, Walmrath D, Grimminger F. Prostacyclin enhances stretch-induced surfactant secretion in alveolar epithelial type II cells. Am J Respir Crit Care Med 160(3):846-851, 1999. 
        65. Sanchez-Esteban J, Cicchiello LA, Wang Y, Tsai S-W, Williams LK, Torday JS, Rubin LP. Mechanical stretch promotes alveolar epithelial type II cell differentiation. J Appl Physiol 91(2):589-595, 2001. 
        66. Sanchez-Esteban J, Tsai SW, Sang J, Qin J, Torday JS, Rubin LP. Effects of mechanical forces on lung-specific gene expression. Am J Med Sci 316(3):200-204, 1998. 
        67. Sanchez-Esteban J, Wang Y, Filardo EJ, Rubin LP, Ingber DE. Integrins β1, α6, and α3 contribute to mechanical strain-induced differentiation of fetal lung type II epithelial cells via distinct mechanisms. Am J Physiol Lung Cell Mol Physiol 290(2):L343-L350, 2006. 
        68. Sanchez-Esteban J, Wang Y, Gruppuso PA, Rubin LP. Mechanical stretch induces fetal type II cell differentiation via an epidermal growth factor receptor-extracellular-regulated protein kinase signaling pathway. Am J Respir Cell Mol Biol 30:76–83, 2004. 
        69. Savla U, Olson LE, Waters CM. Mathematical modeling of airway epithelial wound closure during cyclic mechanical strain. J Appl Physiol 96(2):566-574, 2004. 
        70. Savla U, Sporn PH, Waters CM. Cyclic stretch of airway epithelium inhibits prostanoid synthesis. Am J Physiol Lung Cell Mol Physiol 273:L1013-L1019, 1997. 
        71. Savla U, Waters CM. Mechanical strain inhibits repair of airway epithelium in vitro. Am J Physiol Lung Cell Mol Physiol 274:883-892, 1998. 
        72. Scott JE, Yang SY, Stanik E, Anderson JE. Influence of strain on [3H]thymidine incorporation, surfactant-related phospholipid synthesis, and cAMP levels in fetal type II alveolar cells. Am J Respir Cell Mol Biol 8(3):258-265, 1993.
        73. Takawira D, Budinger GR, Hopkinson SB, Jones JC. A dystroglycan/plectin scaffold mediates mechanical pathway bifurcation in lung epithelial cells. J Biol Chem 286(8):6301-6310, 2011. Epub 2010 Dec 13. 
        74. Taylor W, Gokay KE, Capaccio C, Davis E, Glucksberg M, Dean DA. The effects of cyclic stretch on gene transfer in alveolar epithelial cells. Mol Ther 7(4):542-549, 2003. 
        75. Thomas RA, Norman JC, Huynh TT, Williams B, Bolton SJ, Wardlaw AJ. Mechanical stretch has contrasting effects on mediator release from bronchial epithelial cells, with a rho-kinase-dependent component to the mechanotransduction pathway. Respir Med100(9):1588-1597, 2006. Epub 2006 Feb 15. 
        76. Torday JS, Rehan VK. Stretch-stimulated surfactant synthesis is coordinated by the paracrine actions of PTHrP and leptin. Am J Physiol Lung Cell Mol Physiol 283(1):L130-L135, 2002. 
        77. Torday JS, Torres E, Rehan VK. The role of fibroblast transdifferentiation in lung epithelial cell proliferation, differentiation, and repair in vitro. Pediatr Pathol Mol Med 22(3):189-207, 2003. 
        78. Vlahakis NE, Schroeder MA, Limper AH, Hubmayr RD. Stretch induces cytokine release by alveolar epithelial cells in vitro. Am J Physiol Lung Cell Mol Physiol 277:L167-L173, 1999. 
        79. Wang Y, Huang Z, Nayak PS, Sanchez-Esteban J. An experimental system to study mechanotransduction in fetal lung cells. J Vis Exp (60), 2012. pii: 3543. doi: 10.3791/3543. 
        80. Wang Y, Maciejewski BS, Drouillard D, Santos M, Hokenson MA, Hawwa RL, Huang Z, Sanchez-Esteban J. A role for caveolin-1 in mechanotransduction of fetal type II epithelial cells. Am J Physiol Lung Cell Mol Physiol 298(6):L775-L783, 2010. Epub 2010 Feb 19. 
        81. Wang Y, Maciejewski BS, Lee N, Silbert O, McKnight NL, Frangos JA, Sanchez-Esteban J. Strain-induced fetal type II epithelial cell differentiation is mediated via cAMP-PKA-dependent signaling pathway. Am J Physiol Lung Cell Mol Physiol 291(4):L820-L827, 2006. 
        82. Wang Y, Maciejewski BS, Weissmann G, Silbert O, Han H, Sanchez-Esteban J. DNA microarray reveals novel genes induced by mechanical forces in fetal lung type II epithelial cells. Pediatr Res 60(2):118-124, 2006. 
        83. Waters CM, Ridge KM, Sunio G, Venetsanou K, Sznajder JI. Mechanical stretching of alveolar epithelial cells increases Na+-K+-ATPase activity. J Appl Physiol 87(2):715-721, 1999. 
        84. Waters CM, Savla U. Keratinocyte growth factor accelerates wound closure in airway epithelium during cyclic mechanical strain. J Cell Physiol 181(3):424-432, 1999. 
        85. Wu Q, Shu H, Yao S, Xiang H. Mechanical stretch induces pentraxin 3 release by alveolar epithelial cells in vitro. Med Sci Monit 15(5):BR135-BR140, 2009.

        肺動脈平滑肌細胞(Pulmonary smooth muscle cells)細胞牽張拉伸應力應用文獻

        86. Bonacci JV, Harris T, Stewart AG. Impact of extracellular matrix and strain on proliferation of bovine airway smooth muscle.Clin Exp Pharmacol Physiol 30(5-6):324-328, 2003.
        87. Fairbank NJ, Connolly SC, Mackinnon JD, Wehry K, Deng L, Maksym GN. Airway smooth muscle cell tone amplifies contractile function in the presence of chronic cyclic strain. Am J Physiol Lung Cell Mol Physiol 295(3):L479-L488, 2008. Epub 2008 Jun 27. 
        88. Hasaneen NA, Zucker S, Cao J, Chiarelli C, Panettieri RA, Foda HD. Cyclic mechanical strain-induced proliferation and migration of human airway smooth muscle cells: role of EMMPRIN and MMPs. FASEB J 19(11):1507-1509, 2005. 
        89. Hasaneen NA, Zucker S, Lin RZ, Vaday GG, Panettieri RA, Foda HD. Angiogenesis is induced by airway smooth muscle strain.Am J Physiol Lung Cell Mol Physiol 293(4):L1059-L1068, 2007. Epub 2007 Aug 10. 
        90. Hirst SJ, Martin JG, Bonacci JV, Chan V, Fixman ED, Hamid QA, Herszberg B, Lavoie JP, McVicker CG, Moir LM, Nguyen TT, Peng Q, Ramos-Barbon D, Stewart AG. Proliferative aspects of airway smooth muscle. Journal of Allergy and Clinical Immunology114(2 Suppl):S2-S17, 2004. 
        91. Kumar A, Knox AJ, Boriek AM. CCAAT/enhancer-binding protein and activator protein-1 transcription factors regulate the expression of interleukin-8 through the mitogen-activated protein kinase pathways in response to mechanical stretch of human airway smooth muscle cells. J Biol Chem 278(21):18868-18876, 2003. 
        92. Mata-Greenwood E, Grobe A, Kumar S, Noskina Y, and Black SM. Cyclic stretch increases VEGF expression in pulmonary arterial smooth muscle cells via TGF-β1 and reactive oxygen species: a requirement for NAD(P)H oxidase. Am J Physiol Lung Cell Mol Physiol289(2):L288-L289, 2005. 
        93. Mohamed JS, Boriek AM. Stretch augments TGF-beta1 expression through RhoA/ROCK1/2, PTK, and PI3K in airway smooth muscle cells.Am J Physiol Lung Cell Mol Physiol 299(3):L413-L424, 2010. Epub 2010 May 28. 
        94. Mohamed JS, Lopez MA, Boriek AM. Mechanical stretch up-regulates microRNA-26a and induces human airway smooth muscle hypertrophy by suppressing glycogen synthase kinase-3β. J Biol Chem 285(38):29336-29347, 2010. Epub 2010 Jun 3. 
        95. Ochoa CD, Baker H, Hasak S, Matyal R, Salam A, Hales CA, Hancock W, Quinn DA. Cyclic stretch affects pulmonary endothelial cell control of pulmonary smooth muscle cell growth. Am J Respir Cell Mol Biol 39(1):105-112, 2008. Epub 2008 Feb 28. 
        96. Pasternyk SM, D’Antoni ML, Venkatesan N, Siddiqui S, Martin JG, Ludwig MS. Differential effects of extracellular matrix and mechanical strain on airway smooth muscle cells from ovalbumin- vs. saline-challenged Brown Norway rats. Respir Physiol Neurobiol181(1):36-43, 2012. Epub 2012 Jan 31. 
        97. Quinn TP, Schlueter M, Soifer SJ, Gutierrez JA. Cyclic mechanical stretch induces VEGF and FGF-2 expression in pulmonary vascular smooth muscle cells. Am J Physiol Lung Cell Mol Physiol 282(5):L897-L903, 2002. 
        98. Smith PG, Deng L, Fredberg JJ, Maksym GN. Mechanical strain increases cell stiffness through cytoskeletal filament reorganization. Am J Physiol Lung Cell Mol Physiol 285(2):L456-L463, 2003. 
        99. Smith PG, Garcia R, Kogerman L. Strain reorganizes focal adhesions and cytoskeleton in cultured airway smooth muscle cells. Exp Cell Res 232(1):127-136, 1997. 
        100. Smith PG, Roy C, Dreger J, Brozovich F. Mechanical strain increases velocity and extent of shortening in cultured airway smooth muscle cells. Am J Physiol Lung Cell Mol Physiol 277:L343-L348, 1999. 
        101. Smith PG, Roy C, Fisher S, Huang QQ, Brozovich F. Selected Contribution: Mechanical strain increases force production and calcium sensitivity in cultured airway smooth muscle cells. J Appl Physiol 89(5):2092-2098, 2000. 
        102. Smith PG, Roy C, Zhang YN, Chauduri S. Mechanical stress increases RhoA activation in airway smooth muscle cells. Am J Respir Cell Mol Biol 28(4):436-442, 2003. 
        103. Smith PG, Tokui T, Ikebe M. Mechanical strain increases contractile enzyme activity in cultured airway smooth muscle cells. Am J Physiol 268(6 Pt 1):L999-L1005, 1995. 
        104. Wang L, Liu HW, McNeill KD, Stelmack G, Scott JE, Halayko AJ. Mechanical strain inhibits airway smooth muscle gene transcription via protein kinase C signaling. American Journal of Respiratory Cell Molecular Biology 31:54-61, 2004. 
        105. Wedgwood S, Devol JM, Grobe A, Benavidez E, Azakie A, Fineman JR, Black SM. Fibroblast growth factor-2 expression is altered in lambs with increased pulmonary blood flow and pulmonary hypertension. Pediatr Res 61(1):32-36, 2007.

        其他肺部細胞(Other pulmonary cells)牽張拉伸應力應用文獻

        106. Ding N, Xiao H, Gao J, Xu LX, She SZ. Regulation of P38 and MKK6 on HMGB1 expression in alveolar macrophages induced by cyclic mechanical stretch. Sheng Li Xue Bao 61(1):49-55, 2009. 
        107. Geiger RC, Taylor W, Glucksberg MR, Dean DA. Cyclic stretch-induced reorganization of the cytoskeleton and its role in enhanced gene transfer. Gene Ther 13(8):725-731, 2006. 
        108. Ludwig MS, Ftouhi-Paquin N, Huang W, Pagé N, Chakir J, Hamid Q. Mechanical strain enhances proteoglycan message in fibroblasts from asthmatic subjects. Clin Exp Allergy 34(6):926-930, 2004. 
        109. Ma D, Lu H, Xu L, Xu X, Xiao W. Mechanical loading promotes Lewis lung cancer cell growth through periostin. In Vitro Cell Dev Biol Anim 45(8):467-472, 2009. Epub 2009 Jun 16. 
        110. Muratore CS, Nguyen HT, Ziegler MM, Wilson JM. Stretch-induced upregulation of VEGF gene expression in murine pulmonary culture: A role for angiogenesis in lung development. Journal of Pediatric Surgery 35(6):906-913, 2000. 
        111. Pan J, Copland I, Post M, Yeger H, Cutz E. Mechanical stretch-induced serotonin release from pulmonary neuroendocrine cells: implications for lung development. Am J Physiol Lung Cell Mol Physiol 290(1):L185-L193, 2006. 
        112. Pugin J, Dunn-Siegrist I, Dufour J, Tissières P, Charles PE, Comte R. Cyclic stretch of human lung cells induces an acidification and promotes bacterial growth. Am J Respir Cell Mol Biol 38(3):362-370, 2008. Epub 2007 Oct 5. 
        113. Tepper RS, Ramchandani R, Argay E, Zhang L, Xue Z, Liu Y, Gunst SJ. Chronic strain alters the passive and contractile properties of rabbit airways. J Appl Physiol 98(5):1949-1954, 2005. 
        114. Torday JS, Rehan VK. Stretch-stimulated surfactant synthesis is coordinated by the paracrine actions of PTHrP and leptin. Am J Physiol Lung Cell Mol Physiol 283(1):L130-L135, 2002.

        半月板(Meniscus)細胞牽張拉伸應力應用文獻

        1. Deschner J, Wypasek E, Ferretti M, Rath B, Anghelina M, Agarwal S. Regulation of RANKL by biomechanical loading in fibrochondrocytes of meniscus. J Biomech 39(10):1796-1803, 2006. Epub 2005 Jul 21 
        2. Fermor B, Jeffcoat D, Hennerbichler A, Pisetsky DS, Weinberg JB, Guilak F. The effects of cyclic mechanical strain and tumor necrosis factor α on the response of cells of the meniscus. Osteoarthritis Cartilage 12:956-962, 2004. 
        3. Ferretti M, Madhavan S, Deschner J, Rath-Deschner B, Wypasek E, Agarwal S. Dynamic biophysical strain modulates proinflammatory gene induction in meniscal fibrochondrocytes.Am J Physiol Cell Physiol 290(6):C1610-15, 2006. Epub 2006 Feb 1. 
        4. Upton ML, Hennerbichler A, Fermor B, Guilak F, Weinberg JB, Setton LA. Biaxial strain effects on cells from the inner and outer regions of the meniscus. Connect Tissue Res 47(4):207-214, 2006.

        神經元,星形膠質細胞,及腦(Neurons, Astrocytes, & Brain)細胞牽張拉伸應力應用文獻

        1. Arundine M, Aarts M, Lau A, Tymianski M. Vulnerability of central neurons to secondary insults after in vitro mechanical stretch. J Neurosci 24(37):8106-8123, 2004. 
        2. Arundine M, Chopra GK, Wrong A, Lei S, Aarts MM, MacDonald JF, Tymianski M. Enhanced vulnerability to NMDA toxicity in sublethal traumatic neuronal injury in vitro. Journal of Neurotrauma 20(12):1377-1395, 2003. 
        3. Bhattacharya MR, Bautista DM, Wu K, Haeberle H, Lumpkin EA, Julius D. Radial stretch reveals distinct populations of mechanosensitive mammalian somatosensory neurons. Proc Natl Acad Sci U S A 105(50):20015-20020, 2008. Epub 2008 Dec 5. 
        4. Gladman SJ, Huang W, Lim SN, Dyall SC, Boddy S, Kang JX, Knight MM, Priestley JV, Michael-Titus AT. Improved outcome after peripheral nerve injury in mice with increased levels of endogenous ω-3 polyunsaturated fatty acids. J Neurosci 32(2):563-571, 2012. 
        5. Gladman SJ, Ward RE, Michael-Titus AT, Knight MM, Priestley JV. The effect of mechanical strain or hypoxia on cell death in subpopulations of rat dorsal root ganglion neurons in vitro. Neuroscience 171(2):577-587, 2010. Epub 2010 Jul 29. 
        6. Lau A, Arundine M, Sun HS, Jones M, Tymianski M. Inhibition of caspase-mediated apoptosis by peroxynitrite in traumatic brain injury. J Neurosci 26(45):11540-11553, 2006. 
        7. Ostrow LW, Sachs F. Mechanosensation and endothelin in astrocytes-hypothetical roles in CNS pathophysiology. Brain Research Reviews 48(3):488-508, 2005. 
        8. Uchida K, Nakajima H, Takamura T, Furukawa S, Kobayashi S, Yayama T, Baba H. Gene expression profiles of neurotrophic factors in rat cultured spinal cord cells under cyclic tensile stress. Spine (Phila Pa 1976) 33(24):2596-2604, 2008.

        骨骼肌(Skeletal Muscle)細胞牽張拉伸應力應用文獻

        1. Anderson JE, Wozniak AC. Satellite cell activation on fibers: modeling events in vivo — an invited review. Can J Physiol Pharmacol 82:300–310, 2004.
        2. Boonen KJ, Langelaan ML, Polak RB, van der Schaft DW, Baaijens FP, Post MJ. Effects of a combined mechanical stimulation protocol: Value for skeletal muscle tissue engineering. J Biomech 43(8):1514-1521, 2010. Epub 2010 Feb 26.
        3. Cha MC, Purslow PP. The activities of MMP-9 and total gelatinase respond differently to substrate coating and cyclic mechanical stretching in fibroblasts and myoblasts. Cell Biol Int 34(6):587-591, 2010.
        4. Chandran R, Knobloch TJ, Anghelina M, Agarwal S. Biomechanical signals upregulate myogenic gene induction in the presence or absence of inflammation. Am J Physiol Cell Physiol 293(1):C267-C276, 2007.
        5. Clarke MS, Feeback DL. Mechanical load induces sarcoplasmic wounding and FGF release in differentiated human skeletal muscle cultures. FASEB J 10(4):502-509, 1996.
        6. Demoule A, Divangahi M, Yahiaoui L, Danialou G, Gvozdic D, Labbe K, Bao W, Petrof BJ. Endotoxin triggers nuclear factor-κB-dependent up-regulation of multiple proinflammatory genes in the diaphragm. Am J Respir Crit Care Med 174(6):646-653, 2006. Epub 2006 Jun 15.
        7. Ebihara S, Hussain SN, Danialou G, Cho WK, Gottfried SB, Petrof BJ. Mechanical ventilation protects against diaphragm injury in sepsis: interaction of oxidative and mechanical stresses. Am J Respir Crit Care Med 165(2):221-228, 2002.
        8. Goto K, Okuyama R, Sugiyama H, Honda M, Kobayashi T, Uehara K, Akema T, Sugiura T, Yamada S, Ohira Y, Yoshioka T.Effects of heat stress and mechanical stretch on protein expression in cultured skeletal muscle cells. Pflugers Arch 447(2):247-253, 2003.
        9. Ho AM, Marker PC, Peng H, Quintero AJ, Kingsley DM, Huard J. Dominant negative Bmp5 mutation reveals key role of BMPs in skeletal response to mechanical stimulation. BMC Dev Biol 8:35, 2008.
        10. Hornberger TA, Armstrong DD, Koh TJ, Burkholder TJ, Esser KA. Intracellular signaling specificity in response to uniaxial vs. multiaxial stretch: implications for mechanotransduction. Am J Physiol Cell Physiol 288(1):C185-C194, 2005.
        11. Hornberger TA, Stuppard R, Conley KE, Fedele MJ, Fiorotto ML, Chin ER, Esser KA. Mechanical stimuli regulate rapamycin-sensitive signalling by a phosphoinositide 3-kinase-, protein kinase B- and growth factor-independent mechanism. Biochem J 380(Pt 3):795-804, 2004.
        12. Hubatsch DA, Jasmin BJ. Mechanical stimulation increases expression of acetylcholinesterase in cultured myotubes. Am J Physiol Cell Physiol 273:C2002-C2009, 1997.
        13. Iwanuma O, Abe S, Hiroki E, Kado S, Sakiyama K, Usami A, Ide Y. Effects of mechanical stretching on caspase and IGF-1 expression during the proliferation process of myoblasts. Zoolog Sci 25(3):242-247, 2008.
        14. Kook SH, Lee HJ, Chung WT, Hwang IH, Lee SA, Kim BS, Lee JC. Cyclic mechanical stretch stimulates the proliferation of C2C12 myoblasts and inhibits their differentiation via prolonged activation of p38 MAPK. Mol Cells 25(4):479-486, 2008. Epub 2008 Apr 23.
        15. Kumar A, Murphy R, Robinson P, Wei L, Boriek AM. Cyclic mechanical strain inhibits skeletal myogenesis through activation of focal adhesion kinase, Rac-1 GTPase, and NF-κB transcription factor. FASEB J 18(13):1524-1535, 2004.
        16. Kurokawa K, Abe S, Sakiyama K, Takeda T, Ide Y, Ishigami K. Effects of stretching stimulation with different rates on the expression of MyHC mRNA in mouse cultured myoblasts. Biomed Res 28(1):25-31, 2007.
        17. Liu J, Liu J, Mao J, Yuan X, Lin Z, Li Y. Caspase-3-mediated cyclic stretch-induced myoblast apoptosis via a Fas/FasL-independent signaling pathway during myogenesis. J Cell Biochem 107(4):834-844, 2009.
        18. Milkiewicz M, Doyle JL, Fudalewski T, Ispanovic E, Aghasi M, Haas TL. HIF-1α and HIF-2α play a central role in stretch-induced but not shear-stress-induced angiogenesis in rat skeletal muscle. J Physiol 583(Pt 2):753-766, 2007. Epub 2007 Jul 12.
        19. Milkiewicz M, Mohammadzadeh F, Ispanovic E, Gee E, Haas TL. Static strain stimulates expression of matrix metalloproteinase-2 and VEGF in microvascular endothelium via JNK- and ERK-dependent pathways. J Cell Biochem 100(3):750-761, 2007.
        20. Mitsumoto Y, Downey GP, Klip A. Stimulation of glucose transport in L6 muscle cells by long-term intermittent stretch-relaxation. FEBS Letters 301(1):94-98, 1992.
        21. Miyazaki M, Esser KA. REDD2 is enriched in skeletal muscle and inhibits mTOR signaling in response to leucine and stretch. Am J Physiol Cell Physiol 296(3):C583-C592, 2009. Epub 2009 Jan 7.
        22. Nguyen HX, Lusis AJ, Tidball JG. Null mutation of myeloperoxidase in mice prevents mechanical activation of neutrophil lysis of muscle cell membranes in vitro and in vivo. J Physiol 565(Pt 2):403-13, 2005.
        23. Pardo PS, Mohamed JS, Lopez MA, Boriek AM. Induction of Sirt1 by mechanical stretch of skeletal muscle through the early response factor EGR1 triggers an antioxidative response. J Biol Chem 286(4):2559-2566, 2011. Epub 2010 Oct 22.
        24. Peterson JM, Pizza FX. Cytokines derived from cultured skeletal muscle cells after mechanical strain promote neutrophil chemotaxis in vitro. J Appl Physiol 106:130-137, 2009.
        25. Sampaolesi M, Yoshida T, Iwata Y, Hanada H, Shigekawa M. Stretch-induced cell damage in sarcoglycan-deficient myotubes.Pflügers Arch - Eur J Physiol 442:161–170, 2001.
        26. Tatsumi R, Hattori A, Allen RE, Ikeuchi Y, Ito T. Mechanical stretch-induced activation of skeletal muscle satellite cells is dependent on nitric oxide production in vitro. Animal Sci J 73(3):235-239, 2002.
        27. Tatsumi R, Hattori A, Ikeuchi Y, Anderson JE, Allen RE. Release of hepatocyte growth factor from mechanically stretched skeletal muscle satellite cells and role of pH and nitric oxide. Mol Biol Cell 13(8):2909-2918, 2002.
        28. Tatsumi R, Mitsuhashi K, Ashida K, Haruno A, Hattori A, Ikeuchi Y, Allen RE. Comparative analysis of mechanical stretch-induced activation activity of back and leg muscle satellite cells in vitro. Animal Sci J 75(4):345-351, 2004.
        29. Tatsumi R, Sheehan SM, Iwasaki H, Hattori A, Allen RE. Mechanical stretch induces activation of skeletal muscle satellite cells in vitro. Exp Cell Res 267(1):107-114, 2001.
        30. Tsivitse SK, Mylona E, Peterson JM, Gunning WT, Pizza FX. Mechanical loading and injury induce human myotubes to release neutrophil chemoattractants. Am J Physiol Cell Physiol 288(3):C721-C729, 2005.
        31. Wozniak AC, Anderson JE. The dynamics of the nitric oxide release-transient from stretched muscle cells. Int J Biochem Cell Biol 41(3):625-631, 2009. Epub 2008 Jul 25.
        32. Wozniak AC, Anderson JE. Nitric oxide-dependence of satellite stem cell activation and quiescence on normal skeletal muscle fibers. Dev Dyn 236(1):240-250, 2007.
        33. Wozniak AC, Pilipowicz O, Yablonka RZ, Greenway S, Craven S, Scott E, Anderson JE. C-Met expression and mechanical activation of satellite cells on cultured muscle fibers. J Histochem Cytochem 51(11):1437-1445, 2003.
        34. Yamada M, Sankoda Y, Tatsumi R, Mizunoya W, Ikeuchi Y, Sunagawa K, Allen RE. Matrix metalloproteinase-2 mediates stretch-induced activation of skeletal muscle satellite cells in a nitric oxide-dependent manner.Int J Biochem Cell Biol40(10):2183-2191, 2008. Epub 2008 Feb 23.
        35. Yamashita-Goto K, Ohira Y, Okuyama R, Sugiyama H, Honda M, Sugiura T, Yamada S, Akema T, Yoshioka T. Heat stress facilitates stretch-induced hypertrophy of cultured rat skeletal muscle cells In: Proceedings of "Life in space for life on Earth". 8th European Symposium on Life Sciences Research in Space. 23rd Annual International Gravitational Physiology Meeting, 2-7 June 2002, Karolinska Institutet, Stockholm, Sweden. Ed.: B. Warmbein. ESA SP-501, Noordwijk, Netherlands: ESA Publications Division, ISBN 92-9092-811-5, 2002, p. 113 – 114.
        36. Yu HC, Wu TC, Chen MR, Liu SW, Chen JH, Lin KM. Mechanical stretching induces osteoprotegerin in differentiating C2C12 precursor cells through noncanonical Wnt pathways. J Bone Miner Res 25(5):1128-1137, 2010.
        37. Yuan X, Luo S, Lin Z, Wu Y. Cyclic stretch translocates the α2-subunit of the Na pump to plasma membrane in skeletal muscle cells in vitro. Biochem Biophys Res Commun 348(2):750-757, 2006. Epub 2006 Jul 31.
        38. Zhang SJ, Truskey GA, Kraus WE. Effect of cyclic stretch on β1D integrin expression and activation of FAK and RhoA. Am J Physiol Cell Physiol 292:C2057–C2069, 2007.

         

        平滑肌細胞(Smooth Muscle Cells)牽張拉伸應力應用文獻

        膀胱平滑肌細胞(Bladder smooth muscle cells)牽張拉伸應力應用文獻

        See page 1

        心血管平滑肌細胞(Cardiovascular smooth muscle cells)牽張拉伸應力應用文獻

        See page 19

        肺動脈平滑肌細胞(Pulmonary smooth muscle cells)細胞牽張拉伸應力應用文獻

        See page 51

        子宮/子宮肌層平滑肌細胞(Uterine/myometrial smooth muscle cells)細胞牽張拉伸應力應用文獻

        See page 65

        其他平滑肌細胞(Other smooth muscle cells)細胞牽張拉伸應力應用文獻

        1. Ark M, Sevieux N, Hornick C, He Z, Songu-Mize E. Acute stretch translocates Na-pump α-1 subunit to plasma membrane in smooth muscle cells [abstract]. FASEB J 16:A466, 349.9, 2002. 
        2. Choi K, Mollapour E, Shears SB. Signal transduction during environmental stress: InsP8 operates within highly restricted contexts. Cellular Signalling 17(12):1533-1541, 2005. 
        3. Hoffmann S, Dalrymple A, Tribe R, Songu-Mize E. Stretch regulates expression of TrpC4 in smooth muscle cells [abstract]. FASEB J 18:A702, 459.11, 2004. 
        4. Hoffmann SE, Zhang Z, Songu-Mize E. Effect of cyclic stretch on TRP C expression and calcium mobilization [abstract].Experimental Biology, San Diego, CA, April 2005. 
        5. Sevieux N, Alam J, Songu-Mize E. Na-pump activity and regulation by stretch: a time course study [abstract]. FASEB J 15:A444, 401.6, 2001. 
        6. Shi XZ, Lin YM, Powell DW, Sarna SK. Pathophysiology of motility dysfunction in bowel obstruction: role of stretch-induced COX-2. Am J Physiol Gastrointest Liver Physiol 300(1):G99-G108, 2011. Epub 2010 Nov 4. 
        7. Wehner S, Buchholz BM, Schuchtrup S, Rocke A, Schaefer N, Lysson M, Hirner A, Kalff JC. Mechanical strain and TLR4 synergistically induce cell-specific inflammatory gene expression in intestinal smooth muscle cells and peritoneal macrophages. Am J Physiol Gastrointest Liver Physiol 299(5):G1187-G1197, 2010. Epub 2010 Sep 9.

        基質干細胞/內皮祖細胞/干細胞(Stromal/ Progenitor/ Stem Cells)細胞牽張拉伸應力應用文獻

        1. Ambrosio F, Ferrari RJ, Distefano G, Plassmeyer JM, Carvell GE, Deasy BM, Boninger ML, Fitzgerald GK, Huard J. The synergistic effect of treadmill running on stem-cell transplantation to heal injured skeletal muscle. Tissue Eng Part A 16(3):839-849, 2010.
        2. Bolno PB, Wechsler AS, Ranggappa S, Kresh JY. Cyclic strain of adult stem cells modulates matrix metalloproteinase activity: mechanism for promoting cell-based cardiac remodeling [abstract]. The Journal of Heart and Lung Transplantation 24(2 Suppl):S83, 2005.
        3. Case N, Thomas J, Sen B, Styner M, Xie Z, Galior K, Rubin J. Mechanical regulation of glycogen synthase kinase 3β (GSK3β) in mesenchymal stem cells is dependent on Akt protein serine 473 phosphorylation via mTORC2 protein. J Biol Chem286(45):39450-39456, 2011. Epub 2011 Sep 28.
        4. Case N, Xie Z, Sen B, Styner M, Zou M, O’Conor C, Horowitz M, Rubin J. Mechanical activation of β-catenin regulates phenotype in adult murine marrow-derived mesenchymal stem cells. J Orthop Res 28(11):1531-1538, 2010.
        5. Charoenpanich A, Wall ME, Tucker CJ, Andrews DM, Lalush DS, Loboa EG. Microarray analysis of human adipose-derived stem cells in three-dimensional collagen culture: osteogenesis inhibits bone morphogenic protein and Wnt signaling pathways, and cyclic tensile strain causes upregulation of proinflammatory cytokine regulators and angiogenic factors. Tissue Eng Part A 17(21-22):2615-2627, 2011. Epub 2011 Jul 18.
        6. Chen QZ, Ishii H, Thouas GA, Lyon AR, Wright JS, Blaker JJ, Chrzanowski W, Boccaccini AR, Ali NN, Knowles JC, Harding SE. An elastomeric patch derived from poly(glycerol sebacate) for delivery of embryonic stem cells to the heart.Biomaterials 31(14):3885-3893, 2010. Epub 2010 Feb 11.
        7. Clause KC, Tinney JP, Liu JL, Gharaibeh B, Fujimoto LK, Wagner WR, Ralphe JC, Keller BB, Huard J, Tobita K.Functioning engineered cardiac tissue from skeletal muscle derived stem cells [abstract]. 4th Annual Symposium of AHA Council on Basic Cardiovascular Sciences, Keystone CO, 2007.
        8. Collins JM, Goldspink PH, Russell B. Migration and proliferation of human mesenchymal stem cells is stimulated by different regions of the mechano-growth factor prohormone. J Mol Cell Cardiol 49(6):1042-1045, 2010. Epub 2010 Sep 27.
        9. David V, Marin A, Lafage-Proust MH, Malaval L, Peyroche S, Jones DB, Vico L, Guignandon A. Mechanical loading down-regulates peroxisome proliferator-activated receptor in bone marrow stromal cells and favors ssteoblastogenesis at the expense of adipogenesis. Endocrinology 148(5):2553-2562, 2007.
        10. Fldes G, Mioulane M, Wright JS, Liu AQ, Novak P, Merkely B, Gorelik J, Schneider MD, Ali NN, Harding SE. Modulation of human embryonic stem cell-derived cardiomyocyte growth: a testbed for studying human cardiac hypertrophy J Mol Cell Cardiol50(2):367-376, 2011. Epub 2010 Nov 1.
        11. Gong Z, Niklason LE. Small-diameter human vessel wall engineered from bone marrow-derived mesenchymal stem cells (hMSCs). FASEB J 22(6):1635-1648, 2008. Epub 2008 Jan 16.
        12. Hamilton DW, Maul TM, Vorp DA. Characterization of the response of bone marrow-derived progenitor cells to cyclic strain: implications for vascular tissue-engineering applications. Tissue Engineering 10(3-4):361-369, 2004.
        13. Harada M, Osuga Y, Hirota Y, Koga K, Morimoto C, Hirata T, Yoshino O, Tsutsumi O, Yano T, Taketani Y. Mechanical stretch stimulates interleukin-8 production in endometrial stromal cells: possible implications in endometrium-related events. J Clin Endocrinol Metab 90(2):1144-8, 2005.
        14. Harada M, Osuga Y, Takemura Y, Yoshino O, Koga K, Hirota Y, Hirata T, Morimoto C, Yano T, Taketani Y. Mechanical stretch upregulates insulin-like growth factor binding protein-1 (IGFBP-1) secretion from decidualized endometrial stromal cells.Am J Physiol Endocrinol Metab 290(2):E268-72, 2006
        15. Hegarty PK, Watson RW, Coffey RN, Webber MM, Fitzpatrick JM. Effects of cyclic stretch on prostatic cells in culture. J Urol 168(5):2291-2295, 2002.
        16. Huang CH, Chen MH, Young TH, Jeng JH, Chen YJ. Interactive effects of mechanical stretching and extracellular matrix proteins on initiating osteogenic differentiation of human mesenchymal stem cells. J Cell Biochem 108(6):1263-1273, 2009.
        17. Jakkaraju S, Zhe X, Pan D, Choudhury R, Schuger L. TIPs are
        18. tension-responsive proteins involved in myogenic versus adipogenic differentiation. Developmental Cell 9(1):39-49, 2005.
        19. Kang MN, Yoon HH, Seo YK, Park JK. Effect of mechanical stimulation on the differentiation of cord stem cells. Connect Tissue Res 53(2):149-159, 2012. Epub 2011 Dec 7.
        20. Koike M, Shimokawa H, Kanno Z, Ohya K, Soma K. Effects of mechanical strain on proliferation and differentiation of bone marrow stromal cell line ST2. J Bone Miner Metab 23(3):219-225, 2005.
        21. Ku CH, Johnson PH, Batten P, Sarathchandra P, Chambers RC, Taylor PM, Yacoub MH, Chester AH. Collagen synthesis by mesenchymal stem cells and aortic valve interstitial cells in response to mechanical stretch. Cardiovasc Res 71(3):548-556, 2006. Epub 2006 Apr 7.
        22. Kurpinski K, Park J, Thakar RG, Li S. Regulation of vascular smooth muscle cells and mesenchymal stem cells by mechanical strain. Mol Cell Biomech 3(1):21-34, 2006.
        23. Lee EK, Lee JS, Park HS, Kim CH, Gin YJ, Son Y. Cyclic stretch stimulates cell proliferation of human mesenchymal stem cells but do not induce their apoptosis and differentiation. Tissue Engineering and Regenerative Medicine 2(1):29-33, 2005.
        24. Lee WC, Maul TM, Vorp DA, Rubin JP, Marra KG. Effects of uniaxial cyclic strain on adipose-derived stem cell morphology, proliferation, and differentiation. Biomech Model Mechanobiol 6(4):265-273, 2007. Epub 2006 Aug 12.
        25. MacQuarrie RA, Fang Chen Y, Coles C, Anderson GI. Wear-particle-induced osteoclast osteolysis: the role of particulates and mechanical strain. J Biomed Mater Res B Appl Biomater 69(1):104-112, 2004.
        26. Nieponice A, Maul TM, Cumer JM, Soletti L, Vorp DA. Mechanical stimulation induces morphological and phenotypic changes in bone marrow-derived progenitor cells within a three-dimensional fibrin matrix. J Biomed Mater Res A 81(3):523-530, 2007.
        27. Park JS, Chu JS, Cheng C, Chen F, Chen D, Li S. Differential effects of equiaxial and uniaxial strain on mesenchymal stem cells. Biotechnol Bioeng 88(3):359-68, 2004.
        28. Payne TR, Oshima H, Okada M, Momoi N, Tobita K, Keller BB, Peng H, Huard J. A relationship between vascular endothelial growth factor, angiogenesis, and cardiac repair after muscle stem cell transplantation into ischemic hearts. J Am Coll Cardiol50(17):1677-1684, 2007.
        29. Rahnert J, Fan X, Case N, Murphy TC, Grassi F, Sen B, Rubin J. The role of nitric oxide in the mechanical repression of RANKL in bone stromal cells. Bone 43(1):48-54, 2008. Epub 2008 Mar 20.
        30. Rathbone SR, Glossop JR, Gough JE, Cartmell SH. Cyclic tensile strain upon human mesenchymal stem cells in 2D and 3D culture differentially influences CCNL2, WDR61 and BAHCC1 gene expression levels. J Mech Behav Biomed Mater 11:82-91, 2012. Epub 2012 Feb 3.
        31. Rubin J, Fan X, Biskobing DM, Taylor WR, Rubin CT. Osteoclastogenesis is repressed by mechanical strain in an in vitro model. J Orthop Res 17(5):639-645, 1999.
        32. Rubin J, Murphy T, Nanes MS, Fan X. Mechanical strain inhibits expression of osteoclast differentiation factor by murine stromal cells. Am J Physiol Cell Physiol 278(6):C1126-C1132, 2000.
        33. Rubin J, Murphy TC, Fan X, Goldschmidt M, Taylor WR. Activation of extracellular signal-regulated kinase is involved in mechanical strain inhibition of RANKL expression in bone stromal cells. J Bone Miner Res 17(8):1452-1460, 2002.
        34. Rubin J, Murphy TC, Rahnert J, Song H, Nanes MS, Greenfield EM, Jo H, Fan X. Mechanical inhibition of RANKL expression is regulated by H-Ras-GTPase. J Biol Chem 281(3):1412-1418, 2006.
        35. Rubin J, Murphy TC, Zhu L, Roy E, Nanes MS, Fan X. Mechanical strain differentially regulates endothelial nitric-oxide synthase and receptor activator of nuclear κB ligand expression via ERK1/2 MAPK. J Biol Chem 278(36):34018-34025, 2003.
        36. Saha S, Ji L, de Pablo JJ, Palecek SP. Inhibition of human embryonic stem cell differentiation by mechanical strain. J Cell Physiol 206(1):126-37, 2006.
        37. Saha S, Ji L, de Pablo JJ, Palecek SP. TGFβ/Activin/Nodal pathway in inhibition of human embryonic stem cell differentiation by mechanical strain. Biophys J 94(10):4123-4133, 2008. Epub 2008 Jan 30.
        38. Schmelter M, Ateghang B, Helmig S, Wartenberg M, Sauer H. Embryonic stem cells utilize reactive oxygen species as transducers of mechanical strain-induced cardiovascular differentiation. FASEB J 20:1182-1184, 2006.
        39. Sen B, Xie Z, Case N, Ma M, Rubin C, Rubin J. Mechanical strain inhibits adipogenesis in mesenchymal stem cells by stimulating a durable β-catenin signal. Endocrinology 149(12):6065-6075, 2008. Epub 2008 Aug 7.
        40. Simionescu A, Tedder ME, Chuang T, Simionescu DT. Lectin and antibody-based histochemical techniques for cardiovascular tissue engineering. Journal of Histotechnology 34(1):20-28, 2011.
        41. Simmons CA, Matlis S, Thornton AJ, Chen S, Wang CY, Mooney DJ. Cyclic strain enhances matrix mineralization by adult human mesenchymal stem cells via the extracellular signal-regulated kinase (ERK1/2) signaling pathway. Journal of Biomechanics36(8):1087-1096, 2003.
        42. Sumanasinghe RD, Bernacki SH, Loboa EG. Osteogenic differentiation of human mesenchymal stem cells in collagen matrices: effect of uniaxial cyclic tensile strain on bone morphogenetic protein (BMP-2) mRNA expression. Tissue Eng 12(12):3459-3465, 2006.
        43. Throm Quinlan AM, Sierad LN, Capulli AK, Firstenberg LE, Billiar KL. Combining dynamic stretch and tunable stiffness to probe cell mechanobiology in vitro. PLoS ONE 6(8): e23272, 2011. doi:10.1371/journal.pone.0023272.
        44. Valero MC, Huntsman HD, Liu J, Zou K, Boppart MD. Eccentric exercise facilitates mesenchymal stem cell appearance in skeletal muscle. PLoS One 7(1):e29760, 2012. Epub 2012 Jan 11.
        45. Wall ME, Rachlin A, Otey CA, Loboa EG. Human adipose-derived adult stem cells upregulate palladin during osteogenesis and in response to cyclic tensile strain. American Journal of Physiology: Cell Physiology 293(5):C1532-C1538, 2007. Epub 2007 Aug 8.
        46. Ward DF, Salasznyk RM, Klees RF, Backiel J, Agius P, Bennett K, Boskey A, Plopper GE. Gene focusing and promotes osteogenic differentiation of human mesenchymal stem cells through an extracellular-related kinase-dependent pathway. Stem Cells and Development 16:467–479, 2007.
        47. Wilson CJ, Kasper G, Schütz MA, Duda GN. Cyclic strain disrupts endothelial network formation on Matrigel. Microvasc Res78(3):358-63, 2009. Epub 2009 Aug 18.
        48. Wozniak M, Fausto A, Carron CP, Meyer DM, Hruska KA. Mechanically strained cells of the osteoblast lineage organize their extracellular matrix through unique sites of αVβ3-integrin expression. J Bone Miner Res 15(9):1731-1745, 2000.
        49. Yu HC, Wu TC, Chen MR, Liu SW, Chen JH, Lin KM. Mechanical stretching induces osteoprotegerin in differentiating C2C12 precursor cells through noncanonical Wnt pathways. J Bone Miner Res 25(5):1128-1137, 2010.

        滑膜(Synovial)細胞牽張拉伸應力應用文獻

        1. Bader RA, Wagoner KL. Modulation of the response of rheumatoid arthritis synovial fibroblasts to proinflammatory stimulants with cyclic tensile strain. Cytokine 51(1):35-41, 2010.
        2. Hirata H, Nagakura T, Tsujii M, Morita A, Fujisawa K, Uchida A. The relationship of VEGF and PGE2 expression to extracellular matrix remodelling of the tenosynovium in the carpal tunnel syndrome. J Pathol 204(5):605-612, 2004. 
        3. Lange F, Hartl S, Ungethuem U, Kuban RJ, Hammerschmidt S, Faber S, Morawietz L, Wirtz H, Emmrich F, Krenn V, Sack U.Anti-TNF effects on destructive fibroblasts depend on mechanical stress. Scand J Immunol 64(5):544-553, 2006. 
        4. Momberger TS, Levick JR, Mason RM. Hyaluronan secretion by synoviocytes is mechanosensitive. Matrix Biology 24(8):510-519, 2005.
        5. Momberger TS, Levick JR, Mason RM. Mechanosensitive synoviocytes: a Ca2+ -PKCα-MAP kinase pathway contributes to stretch-induced hyaluronan synthesis in vitro. Matrix Biol 25(5):306-316, 2006. 
        6. Sambajon VV, Cillo JE, Gassner RJ, Buckley MJ. The effects of mechanical strain on synovial fibroblasts. Journal of Oral and Maxillofacial Surgery 61(6):707-712, 2003. 
        7. Tsujii M, Hirata H, Yoshida T, Imanaka-Yoshida K, Morita A, Uchida A. Involvement of tenascin-C and PG-M/versican in flexor tenosynovial pathology of idiopathic carpal tunnel syndrome. Histol Histopathol 21(5):511-518, 2006.

        肌腱(Tendon)細胞牽張拉伸應力應用文獻

        1. Ahearne M, Bagnaninchi PO, Yang Y, El Haj AJ. Online monitoring of collagen fibre alignment in tissue-engineered tendon by PSOCT. J Tissue Eng Regen Med 2(8):521-524, 2008. 
        2. Almekinders LC, Banes AJ, Ballenger CA. Effects of repetitive motion on human fibroblasts. Med Sci Sports Exerc 25(5):603-607, 1993. 
        3. Archambault J, Tsuzaki M, Herzog W, Banes AJ. Stretch and interleukin-1β induce matrix metalloproteinases in rabbit tendon cells in vitro. Journal of Orthopaedic Research 20(1):36-39, 2002. 
        4. Arnoczky SP, Tian T, Lavagnino M, Gardner K, Schuler P, Morse P. Activation of stress-activated protein kinases (SAPK) in tendon cells following cyclic strain: the effects of strain frequency, strain magnitude, and cytosolic calcium. Journal of Orthopaedic Research 20(5):947-952, 2002. 
        5. Backman LJ, Fong G, Andersson G, Scott A, Danielson P. Substance P is a mechanoresponsive, autocrine regulator of human tenocyte proliferation. PLoS One 6(11):e27209, 2011. Epub 2011 Nov 1. 
        6. Banes AJ, Gilbert J, Taylor D, Monbureau O. A new vacuum-operated stress-providing instrument that applies static or variable duration cyclic tension or compression to cells in vitro. J Cell Sci 75:35-42, 1985. 
        7. Banes AJ, Horesovsky G, Larson C, Tsuzaki M, Judex S, Archambault J, Zernicke R, Herzog W, Kelley S, Miller L.Mechanical load stimulates expression of novel genes in vivo and in vitro in avian flexor tendon cells. Osteoarthritis Cartilage7(1):141-153, 1999. 
        8. Banes AJ, Tsuzaki M, Lawrence WT, Ralphs J, Benjamin M, Pederson D, Brown T. Gap junction connexin expression is upregulated by cyclic mechanical load in avian tendon cells. Biorheology 32(2):177, 1995. 
        9. Banes AJ, Tsuzaki M, Peiqi H, Brigman B, Brown T, Almekinders L, Lawrence WT, Fischer T. PDGF-BB, IGF-I and mechanical load stimulate DNA synthesis in avian tendon fibroblasts in vitro. Journal of Biomechanics 28(12):1505-1513, 1995. 
        10. Banes AJ, Tsuzaki M, Yang X, Faber J, Brown T, Boitano S. Uniform biaxial strain stimulates immediate and downstream responses in tendon cells. Annals of Biomedical Engineering 25(1):S77, 1997. 
        11. Banes AJ, Weinhold P, Yang X, Tsuzaki M, Bynum D, Bottlang M, Brown T. Gap junctions regulate responses of tendon cells ex vivo to mechanical loading. Clin Orthop Relat Res (367 Suppl):S356-S370, 1999. 
        12. Chen CH, Marymont JV, Huang MH, Geyer M, Luo ZP, Liu X. Mechanical strain promotes fibroblast gene expression in presence of corticosteroid. Connect Tissue Res 48(2):65-9, 2007.

        13. Elfervig M, Archambault J, Herzog W, Bynum D, Banes AJ. Mechanical

        stretching induces increased intracellular Ca2+ in human tendon cells [abstract]. Transactions of the 47th Annual Meeting of the Orthopaedic Research Society 26:566, 2001. 
        14. Elfervig MK, Yang X, Tsuzaki M, Banes AJ. Mechanical strain and norepinephrine synergize to increase Ca2+ signaling and cell coupling in tendon cells [abstract]. Transactions of the 48th Annual Meeting of the Orthopaedic Research Society 27:596, 2002. 
        15. Garvin J, Qi J, Maloney M, Banes AJ. Novel system for engineering bioartificial tendons and application of mechanical load.Tissue Eng 9(5):967-979, 2003. 
        16. Gilbert JA, Weinhold PS, Banes AJ, Link GW, Jones GL. Strain profiles for circular cell culture plates containing flexible surfaces employed to mechanically deform cells in vitro. Journal of Biomechanics 27(9):1169-1177, 1994. 
        17. Hirata H, Nagakura T, Tsujii M, Morita A, Fujisawa K, Uchida A. The relationship of VEGF and PGE2 expression to extracellular matrix remodelling of the tenosynovium in the carpal tunnel syndrome. J Pathol 204(5):605-612, 2004. 
        18. Qi J, Chi L, Bynum D, Banes AJ. Gap junctions in IL-1β-mediated cell survival response to strain. J Appl Physiol 110(5):1425-1431, 2011. Epub 2011 Jan 6. 
        19. Qi J, Chi L, Maloney M, Yang X, Bynum D, Banes AJ. Interleukin-1β increases elasticity of human bioartificial tendons.Tissue Eng 12(10):2913-2925, 2006. 
        20. Qi J, Fox AM, Alexopoulos LG, Chi L, Bynum D, Guilak F, Banes AJ. IL-1β decreases the elastic modulus of human tenocytes.J Appl Physiol 101(1):189-95, 2006. 
        21. Ralphs JR, Waggett AD, Benjamin M. Actin stress fibres and cell-cell adhesion molecules in tendons: organisation in vivo and response to mechanical loading of tendon cells in vitro. Matrix Biology 21(1):67-74, 2002. 
        22. Triantafillopoulos IK, Banes AJ, Bowman KF Jr, Maloney M, Garrett WE Jr, Karas SG. Nandrolone decanoate and load increase remodeling and strength in human supraspinatus bioartificial tendons. Am J Sports Med 32(4):934-943, 2004. 
        23. Triantafillopoulos IK, Banes AJ, Elfervig MK, Garrett WE, Karas SG. Nandrolone decanoate and loading enhance intercellular calcium signalling in human supraspinatus tendon cells [abstract]. J Bone Joint Surg Br Orthopaedic Proceedings 86-B:171, 2004. 
        24. Tsujii M, Hirata H, Yoshida T, Imanaka-Yoshida K, Morita A, Uchida A. Involvement of tenascin-C and PG-M/versican in flexor tenosynovial pathology of idiopathic carpal tunnel syndrome. Histol Histopathol 21(5):511-518, 2006. 
        25. Tsuzaki M, Bynum D, Almekinders L, Faber J, Banes AJ. Mechanical loading stimulates ecto-ATPase activity in human tendon cells. J Cell Biochem 96(1):117-125, 2003. 
        26. Tsuzaki M, Bynum D, Almekinders L, Yang X, Faber J, Banes AJ. ATP modulates load-inducible IL-1β, COX 2, and MMP-3 gene expression in human tendon cells. J Cell Biochem 89(3):556-562, 2003. 
        27. Wall ME, Banes AJ. Mechanically-induced strain upregulates connexin-43 mRNA expression in tendon cells [abstract]. Transactions of the 50th Annual Meeting of the Orthopaedic Research Society 29:827, 2004
        28. Wall ME, Otey C, Qi J, Banes AJ. Connexin 43 is localized with actin in tenocytes. Cell Motil Cytoskeleton 64(2):121-130, 2007.
        29. Wall ME, Weinhold PS, Siu T, Brown TD, Banes AJ. Comparison of cellular strain with applied substrate strain in vitro. J Biomech 40(1):173-181, 2007.

        子宮(Uterine)細胞牽張拉伸應力應用文獻

        1. Korita D, Itoh H, Sagawa N, Yura S, Yoshida M, Kakui K, Takemura M, Nuamah MA, Fujii S. Cyclic mechanical stretching and interleukin-1α synergistically up-regulate prostacyclin secretion in cultured human uterine myometrial cells. Gynecol Endocrinol 18(3):130-7, 2004. 
        2. Korita D, Sagawa N, Itoh H, Yura S, Yoshida M, Kakui K, Takemura M, Yokoyama C, Tanabe T, Fujii S. Cyclic mechanical stretch augments prostacyclin production in cultured human uterine myometrial cells from pregnant women: possible involvement of up-regulation of prostacyclin synthase expression. J Clin Endocrinol Metab 87(11):5209-5219, 2002. 
        3. Mohan AR, Sooranna SR, Lindstrom TM, Johnson MR, Bennett PR. The effect of mechanical stretch on cyclooxygenase type 2 expression and activator protein-1 and nuclear factor-κB activity in human amnion cells. Endocrinology 148(4):1850-1857, 2007. Epub 2007 Jan 11. 
        4. Sooranna SR, Engineer N, Loudon JA, Terzidou V, Bennett PR, Johnson MR. The mitogen-activated protein kinase dependent expression of prostaglandin H synthase-2 and interleukin-8 messenger ribonucleic acid by myometrial cells: the differential effect of stretch and interleukin-1β. J Clin Endocrinol Metab 90(6):3517-3527, 2005. 
        5. Sooranna SR, Lee Y, Kim LU, Mohan AR, Bennett PR, Johnson MR. Mechanical stretch activates type 2 cyclooxygenase via activator protein-1 transcription factor in human myometrial cells. Mol Hum Reprod 10(2):109-113, 2004. 
        6. Takemura M, Itoh H, Sagawa N, Yura S, Korita D, Kakui K, Hirota N, Fujii S. Cyclic mechanical stretch augments both interleukin-8 and monocyte chemotactic protein-3 production in the cultured human uterine cervical fibroblast cells. Mol Hum Reprod10(8):573-580, 2004. 
        7. Takemura M, Itoh H, Sagawa N, Yura S, Korita D, Kakui K, Kawamura M, Hirota N, Maeda H, Fujii S. Cyclic mechanical stretch augments hyaluronan production in cultured human uterine cervical fibroblast cells. Mol Hum Reprod 11(9):659-665, 2005. 
        8. Yoshida M, Sagawa N, Itoh H, Yura S, Takemura M, Wada Y, Sato T, Ito A, Fujii S. Prostaglandin F(2α), cytokines and cyclic mechanical stretch augment matrix metalloproteinase-1 secretion from cultured human uterine cervical fibroblast cells. Mol Hum Reprod 8(7):681-687, 2002.

        子宮/子宮肌層平滑肌細胞(Uterine/myometrial smooth muscle cells)細胞牽張拉伸應力應用文獻

        9. Dalrymple A, Mahn K, Poston L, Songu-Mize E, Tribe R. Mechanical stretch regulates TrpC proteins and calcium entry in human myometrial smooth muscle cells [abstract]. J Soc Gynecol Invest 11(2 Suppl):225A, 2004. 
        10. Dalrymple A, Mahn K, Poston L, Songu-Mize E, Tribe RM. Mechanical stretch regulates TRPC expression and calcium entry in human myometrial smooth muscle cells. Mol Hum Reprod 13(3):31-39, 2007. 
        11. Loudon JA, Sooranna SR, Bennett PR, Johnson MR. Mechanical stretch of human uterine smooth muscle cells increases IL-8 mRNA expression and peptide synthesis. Mol Hum Reprod 10(12):895-899, 2004. 
        12. Mitchell JA, Shynlova O, Langille BL, Lye SJ. Mechanical stretch and progesterone differentially regulate activator protein-1 transcription factors in primary rat myometrial smooth muscle cells. Am J Physiol Endocrinol Metab 287(3):E439-E445, 2004. 
        13. Oldenhof AD, Shynlova OP, Liu M, Langille BL, Lye SJ. Mitogen-activated protein kinases mediate stretch-induced c-fos mRNA expression in myometrial smooth muscle cells. Am J Physiol Cell Physiol 283(5):C1530-C1539, 2002. 
        14. Shynlova OP, Oldenhof AD, Liu M, Langille L, Lye SJ. Regulation of c-fos expression by static stretch in rat myometrial smooth muscle cells. Am J Obstet Gynecol 186(6):1358-1365, 2002. 
        15. Shynlova O, Tsui P, Dorogin A, Lye SJ. Monocyte chemoattractant protein-1 (CCL-2) integrates mechanical and endocrine signals that mediate term and preterm labor. J Immunol 181(2):1470-1479, 2008. 
        16. Sooranna SR, Engineer N, Liang Z, Bennett PR, Johnson MR; Imperial College Parturition Research Group. Stretch and interleukin 1β: pro-labour factors with similar mitogen-activated protein kinase effects but differential patterns of transcription factor activation and gene expression. J Cell Physiol 212(1):195-206, 2007. 
        17. Sooranna SR, Grigsby P, Myatt L, Bennett PR, Johnson MR. Prostanoid receptors in human uterine myocytes: the effect of reproductive state and stretch. Mol Hum Reprod 11(12):859-864, 2005. 
        18. Sooranna SR, Grigsby PL, Engineer N, Liang Z, Sun K, Myatt L, Johnson MR. Myometrial prostaglandin E2 synthetic enzyme mRNA expression: spatial and temporal variations with pregnancy and labour. Mol Hum Reprod 12(10):625-631, 2006. 
        19. Terzidou V, Sooranna SR, Kim LU, Thornton S, Bennett PR, Johnson MR. Mechanical stretch up-regulates the human oxytocin receptor in primary human uterine myocytes. J Clin Endocrinol Metab 90(1):237-246, 2005.

        其他類型的細胞(Other Cell Types)細胞牽張拉伸應力應用文獻

        1. Alman BA, Greel DA, Ruby LK, Goldberg MJ, Wolfe HJ. Regulation of proliferation and platelet-derived growth factor expression in palmar fibromatosis (Dupuytren contracture) by mechanical strain. J Orthop Res 14(5):722-8, 1996. 
        2. Balestrini JL, Billiar KL. Magnitude and duration of stretch modulate fibroblast remodeling. J Biomech Eng 131(5):051005, 2009.
        3. Branski RC, Perera P, Verdolini K, Rosen CA, Hebda PA, Agarwal S. Dynamic biomechanical strain inhibits IL-1β-induced inflammation in vocal fold fibroblasts. J Voice 21(6):651-660, 2007. Epub 2006 Aug 14. 
        4. Ferdous Z, Lazaro LD, Iozzo RV, Hk M, Grande-Allen KJ. Influence of cyclic strain and decorin deficiency on 3D cellularized collagen matrices. Biomaterials 29(18):2740-2748, 2008. Epub 2008 Apr 3. 
        5. Foolen J, Deshpande VS, Kanters FM, Baaijens FP. The influence of matrix integrity on stress-fiber remodeling in 3D.Biomaterials 33(30):7508-7518, 2012. Epub 2012 Jul 20. 
        6. Giannone G, Jiang G, Sutton DH, Critchley DR, Sheetz MP. Talin1 is critical for force-dependent reinforcement of initial integrin-cytoskeleton bonds but not tyrosine kinase activation. J Cell Biol 163(2):409-419, 2003. 
        7. Han B, Bai XH, Lodyga M, Xu J, Yang BB, Keshavjee S, Post M, Liu M. Conversion of mechanical force into biochemical signaling. J Biol Chem 279(52):54793-54801, 2004. 
        8. Jing Q, Guang-yun Z, Zhen T, Yue Z, Jiang-bo Y, Xiao Y. Effects of p38MAPK signaling pathway on cyclic tensile stress-induced fibroblast apoptosis. Journal of Clinical Rehabilitative Tissue Engineering Research 15(20):3789-3792, 2011. 
        9. Lee SK, Lee CY, Kook YA, Lee SK, Kim EC. Mechanical stress promotes odontoblastic differentiation via the heme oxygenase-1 pathway in human dental pulp cell line. Life Sci 86(3-4):107-114, 2010. Epub 2009 Dec 3. 
        10. Lutz R, Sakai T, Chiquet M. Pericellular fibronectin is required for RhoA-dependent responses to cyclic strain in fibroblasts. J Cell Sci 123(Pt 9):1511-1521, 2010. Epub 2010 Apr 7. 
        11. Matheson LA, Maksym GN, Santerre JP, Labow RS. Cyclic biaxial strain affects U937 macrophage-like morphology and enzymatic activities. J Biomed Mater Res A 76(1):52-62, 2006. 
        12. Matheson LA, Maksym GN, Santerre JP, Labow RS. Differential effects of uniaxial and biaxial strain on U937 macrophage-like cell morphology: Influence of extracellular matrix type proteins. J Biomed Mater Res A 81:971-981, 2007. 
        13. Matheson LA, Maksym GN, Santerre JP, Labow RS. The functional response of U937 macrophage-like cells is modulated by extracellular matrix proteins and mechanical strain. Biochem Cell Biol 84(5):763-773, 2006. 
        14. Osada T, Watanabe S, Tanaka H, Hirose M, Miyazaki A, Sato N. Effect of mechanical strain on gastric cellular migration and proliferation during mucosal healing: role of Rho dependent and Rac dependent cytoskeletal reorganization. Gut 45(4):508-515, 1999. 
        15. Pereira AM, Tudor C, Kanger JS, Subramaniam V, Martin-Blanco E. Integrin-dependent activation of the JNK signaling pathway by mechanical stress. PLoS One 6(12):e26182, 2011. Epub 2011 Dec 13. 
        16. Sawada Y, Sheetz MP. Force transduction by Triton cytoskeletons. J Cell Bio 156:609-615, 2002. 
        17. Vollmer T, Hinse D, Kleesiek K, Dreier J. Interactions between endocarditis-derived Streptococcus gallolyticus subsp. gallolyticus isolates and human endothelial cells. BMC Microbiol 10:78, 2010.
        18.Wehner S, Buchholz BM, Schuchtrup S, Rocke A, Schaefer N, Lysson M, Hirner A, Kalff JC. Mechanical strain and TLR4 synergistically induce cell-specific inflammatory gene expression in intestinal smooth muscle cells and peritoneal macrophages. Am J Physiol Gastrointest Liver Physiol 299(5):G1187-G1197, 2010. Epub 2010 Sep 9. 
        19. Yu J, Xie YJ, Xu D, Zhao SL. Effect of cyclic strain on cell morphology, viability and proliferation of human dental pulp cells in vitro. Shanghai Kou Qiang Yi Xue 18(6):599-603, 2009. 
        20. Zong W, Jallah ZC, Stein SE, Abramowitch SD, Moalli PA. Repetitive mechanical stretch increases extracellular collagenase activity in vaginal fibroblasts. Female Pelvic Med Reconstr Surg 16(5):257-262, 2010.

        點評與評論文章(Reviews & Commentaries)細胞牽張拉伸應力應用文獻

        1. Anderson JE, Wozniak AC. Satellite cell activation on fibers: modeling events in vivo — an invited review. Can J Physiol Pharmacol 82:300–310, 2004. 
        2. Brown TD. Techniques for mechanical stimulation of cells in vitro: a review. Journal of Biomechanics 33(1):3-14, 2000. 
        3. Cummins PM, Cotter EJ, Cahill PA. Hemodynamic regulation of metallopeptidases within the vasculature. Protein Pept Lett11(5):433-442, 2004. 
        4. Cummins PM, von Offenberg Sweeney N, Killeen MT, Birney YA, Redmond EM, Cahill PA. Cyclic strain-mediated matrix metalloproteinase regulation within the vascular endothelium: a force to be reckoned with. Am J Physiol Heart Circ Physiol 292:H28–H42, 2007. 
        5. Gupta V, Grande-Allen KJ. Effects of static and cyclic loading in regulating extracellular matrix synthesis by cardiovascular cells. Cardiovasc Res 72(3):375-383, 2006. Epub 2006 Sep 1. 
        6. Hirst SJ, Martin JG, Bonacci JV, Chan V, Fixman ED, Hamid QA, Herszberg B, Lavoie JP, McVicker CG, Moir LM, Nguyen TT, Peng Q, Ramos-Barbon D, Stewart AG. Proliferative aspects of airway smooth muscle. Journal of Allergy and Clinical Immunology114(2 Suppl):S2-S17, 2004. 
        7. Kurpinski K, Park J, Thakar RG, Li S. Regulation of vascular smooth muscle cells and mesenchymal stem cells by mechanical strain. Mol Cell Biomech 3(1):21-34, 2006. 
        8. McPartland JM. The endocannabinoid system: an osteopathic perspective. J Am Osteopath Assoc 108(10):586-600, 2008. 
        9. Noda M, Takuwa Y, Katoh T, Kurokawa K. Stretch-induced parathyroid hormone-related peptide gene expression: implication in the regulation of myogenic tone. Curr Opin Nephrol Hypertens 4(5):383-387, 1995. 
        10. Ostrow LW, Sachs F. Mechanosensation and endothelin in astrocytes-hypothetical roles in CNS pathophysiology. Brain Research Reviews 48(3):488-508, 2005. 
        11. Park JS, Huang NF, Kurpinski KT, Patel S, Hsu S, Li S. Mechanobiology of mesenchymal stem cells and their use in cardiovascular repair. Front Biosci 12:5098-5116, 2007. 
        12. Rakugi H, Yu H, Kamitani A, Nakamura Y, Ohishi M, Kamide K, Nakata Y, Takami S, Higaki J, Ogihara T. Links between hypertension and myocardial infarction. American Heart Journal 132(1 Pt 2 Su):213-221, 1996.
        13. Songu-Mize E, Liu X, Hymel LJ. Effect of mechanical strain on expression of Na+,K+-ATPase α subunits in rat aortic smooth muscle cells. Amer J Med Sci 316(3):196-199, 1998. 
        14. Takei T, Mills I, Arai K, Sumpio BE. Molecular basis for tissue expansion: clinical implications for the surgeon. Plast Reconstr Surg 102(1):247-258, 1998. 
        15. Tanaka S, Hamanishi C, Kikuchi H, Fukuda K. Factors related to degradation of articular cartilage in osteoarthritis: a review. Semin Arthritis Rheum 27(6):392-399, 1998. 
        16. Thompson MS, Epari DR, Bieler F, Duda GN. In vitro models for bone mechanobiology: applications in bone regeneration and tissue engineering. Proc Inst Mech Eng H 224(12):1533-1541, 2010. 
        17. Vandenburgh HH. Mechanical forces and their second messengers in stimulating cell growth in vitro. Am J Physiol Regulatory Integrative Comp Physiol 262(3):R350-355, 1992. 
        18. Zhang Y, Sekar RB, McCulloch AD, Tung L. Cell cultures as models of cardiac mechanoelectric feedback. Prog Biophys Mol Biol97(2-3):367-382, 2008. Epub 2008 Feb 16.

        UNIFLEX®和單軸拉伸(UNIFLEX®AND UNIAXIAL TENSION)細胞牽張拉伸應力應用文獻

        1. Bhatt KA, Chang EI, Warren SM, Lin SE, Bastidas N, Ghali S, Thibboneir A, Capla JM, McCarthy JG, Gurtner GC. Uniaxial mechanical strain: an in vitro correlate to distraction osteogenesis. J Surg Res 143(2):329-336, 2007. Epub 2007 Oct 22. 
        2. Boonen KJ, Langelaan ML, Polak RB, van der Schaft DW, Baaijens FP, Post MJ. Effects of a combined mechanical stimulation protocol: Value for skeletal muscle tissue engineering. J Biomech 43(8):1514-1521, 2010. Epub 2010 Feb 26. 
        3. Ghosh K, Thodeti CK, Dudley AC, Mammoto A, Klagsbrun M, Ingber DE. Tumor-derived endothelial cells exhibit aberrant Rho-mediated mechanosensing and abnormal angiogenesis in vitro. Proc Natl Acad Sci U S A 105(32):11305-11310, 2008. Epub 2008 Aug 6. 
        4. Hamilton DW, Maul TM, Vorp DA. Characterization of the response of bone marrow-derived progenitor cells to cyclic strain: implications for vascular tissue-engineering applications. Tissue Engineering 10(3-4):361-369, 2004. 
        5. Jones BF, Wall ME, Carroll RL, Washburn S, Banes AJ. Ligament cells stretch-adapted on a microgrooved substrate increase intercellular communication in response to a mechanical stimulus. J Biomech 38(8):1653-1664, 2005. 
        6. Lee WC, Maul TM, Vorp DA, Rubin JP, Marra KG. Effects of uniaxial cyclic strain on adipose-derived stem cell morphology, proliferation, and differentiation. Biomech Model Mechanobiol 6(4):265-273, 2007. Epub 2006 Aug 12. 
        7. Matheson LA, Jack FN, Maksym GN, Paul SJ, Labow RS. Characterization of the Flexcell Uniflex cyclic strain culture system with U937 macrophage-like cells. Biomaterials 27(2):226-233, 2006. 
        8. Matheson LA, Maksym GN, Santerre JP, Labow RS. Differential effects of uniaxial and biaxial strain on U937 macrophage-like cell morphology: Influence of extracellular matrix type proteins. J Biomed Mater Res A 81:971-981, 2007. 
        9. Matheson LA, Maksym GN, Santerre JP, Labow RS. The functional response of U937 macrophage-like cells is modulated by extracellular matrix proteins and mechanical strain. Biochem Cell Biol 84(5):763-773, 2006. 
        10. Sedding DG, Hermsen J, Seay U, Eickelberg O, Kummer W, Schwencke C, Strasser RH, Tillmanns H, Braun-Dullaeus RC. Caveolin-1 facilitates mechanosensitive protein kinase B (Akt) signaling in vitro and in vivo. Circ Res 96(6):635-642, 2005. 
        11. Sedding DG, Homann M, Seay U, Tillmanns H, Preissner KT, Braun-Dullaeus RC. Calpain counteracts mechanosensitive apoptosis of vascular smooth muscle cells in vitro and in vivo. FASEB J 22(2):579-589, 2008. Epub 2007 Sep 10. 
        12. Thodeti CK, Matthews B, Ravi A, Mammoto A, Ghosh K, Bracha AL, Ingber DE. TRPV4 channels mediate cyclic strain-induced endothelial cell reorientation through integrin-to-integrin signaling. Circ Res 104(9):1123-1130, 2009. Epub 2009 Apr 9. 
        13.Wescott DC, Pinkerton MN, Gaffey BJ, Beggs KT, Milne TJ, Meikle MC. Osteogenic gene expression by human periodontal ligament cells under cyclic tension. J Dent Res 86(12):1212-1216, 2007. 
        14. Wilson CJ, Kasper G, Schütz MA, Duda GN. Cyclic strain disrupts endothelial network formation on Matrigel. Microvasc Res78(3):358-63, 2009. Epub 2009 Aug 18.

        組織列車®和三維培養系統(TISSUE TRAIN®AND 3D CULTURE SYSTEM)細胞三維培養系統應用文獻

        1. Abraham T, Kayra D, McManus B, Scott A. Quantitative assessment of forward and backward second harmonic three dimensional images of collagen Type I matrix emodeling in a stimulated cellular environment. J Struct Biol 180(1):17-25, 2012. doi: 10.1016/j.jsb.2012.05.004. Epub 2012 May 15.
        2. Ahearne M, Bagnaninchi PO, Yang Y, El Haj AJ. Online monitoring of collagen fibre alignment in tissue-engineered tendon by PSOCT. J Tissue Eng Regen Med 2(8):521-524, 2008.
        3. Allison DA, Wight TN, Ripp NJ, Braun KR, Grande-Allen KJ. Endogenous overexpression of hyaluronan synthases within dynamically cultured collagen gels: Implications for vascular and valvular disease. Biomaterials 29:2969-2976, 2008.
        4. Charoenpanich A, Wall ME, Tucker CJ, Andrews DM, Lalush DS, Loboa EG. Microarray analysis of human adipose-derived stem cells in three-dimensional collagen culture: osteogenesis inhibits bone morphogenic protein and Wnt signaling pathways, and cyclic tensile strain causes upregulation of proinflammatory cytokine regulators and angiogenic factors. Tissue Eng Part A 17(21-22):2615-2627, 2011. Epub 2011 Jul 18.
        5. Clause KC, Tinney JP, Liu LJ, Gharaibeh B, Huard J, Kirk JA, Shroff SG, Fujimoto KL, Wagner WR, Ralphe JC, Keller BB, Tobita K. A three-dimensional gel bioreactor for assessment of cardiomyocyte induction in skeletal muscle-derived stem cells. Tissue Eng Part C Methods 16(3):375-385, 2010.
        6. Clause KC, Tinney JP, Liu LJ, Keller BB, Tobita K. Engineered early embryonic cardiac tissue increases cardiomyocyte proliferation by cyclic mechanical stretch via p38-MAP kinase phosphorylation. Tissue Engineering Part A 15(6):1373-1380, 2009.
        7. Clause KC, Tinney JP, Liu JL, Keller BB, Huard J, Tobita K. p38MAP-kinase regulates cardiomyocyte proliferation and contractile properties of engineered early embryonic cardiac tissue [abstract]. Weinstein Cardiovascular Development Research Conference, Indianapolis, IN, 2007.
        8. Clause KC, Tinney JP, Liu JL, Gharaibeh B, Fujimoto LK, Wagner WR, Ralphe JC, Keller BB, Huard J, Tobita K.Functioning engineered cardiac tissue from skeletal muscle derived stem cells [abstract]. 4th Annual Symposium of AHA Council on Basic Cardiovascular Sciences, Keystone CO, 2007.
        9. Ferdous Z, Lazaro LD, Iozzo RV, Hk M, Grande-Allen KJ. Influence of cyclic strain and decorin deficiency on 3D cellularized collagen matrices. Biomaterials 29(18):2740-2748, 2008. Epub 2008 Apr 3.
        10. Garvin J, Qi J, Maloney M, Banes AJ. Novel system for engineering bioartificial tendons and application of mechanical load.Tissue Eng 9(5):967-979, 2003.
        11. Henshaw DR, Attia E, Bhargava M, Hannafin JA. Canine ACL fibroblast integrin expression and cell alignment in response to cyclic tensile strain in three-dimensional collagen gels. J Orthop Res 24(3):481-490, 2006.
        12. Jobling AI, Gentle A, Metlapally R, McGowan BJ, McBrien NA. Regulation of scleral cell contraction by transforming growth factor-β and stress: competing roles in myopic eye growth. J Biol Chem 284(4):2072-2079, 2009. Epub 2008 Nov 14.

        13. Lee CH, Shin HJ, Cho IH, Kang YM, Kim IA, Park KD, Shin JW. Nanofiber alignment and direction of mechanical strain affect the ECM production of human ACL fibroblast. Biomaterials 26(11):1261-1270, 2005. 
        14. Nieponice A, Maul TM, Cumer JM, Soletti L, Vorp DA. Mechanical stimulation induces morphological and phenotypic changes in bone marrow-derived progenitor cells within a three-dimensional fibrin matrix. J Biomed Mater Res A 81(3):523-530, 2007. 
        15. Nourse MB, Halpin DE, Scatena M, Mortisen DJ, Tulloch NL, Hauch KD, Torok-Storb B, Ratner BD, Pabon L, Murry CE.VEGF induces differentiation of functional endothelium from human embryonic stem cells: implications for tissue engineering.Arterioscler Thromb Vasc Biol 30(1):80-89, 2010. Epub 2009 Oct 29. 
        16. Qi J, Chi L, Bynum D, Banes AJ. Gap junctions in IL-1β-mediated cell survival response to strain. J Appl Physiol 110(5):1425-1431, 2011. Epub 2011 Jan 6. 
        17. Qi J, Chi L, Faber J, Koller B, Banes AJ. ATP reduces gel compaction in osteoblast-populated collagen gels. J Appl Physiol102(3):1152-60, 2007. 
        18. Qi J, Chi L, Maloney M, Yang X, Bynum D, Banes AJ. Interleukin-1β increases elasticity of human bioartificial tendons.Tissue Eng 12(10):2913-2925, 2006. 
        19. Qi J, Fox AM, Alexopoulos LG, Chi L, Bynum D, Guilak F, Banes AJ. IL-1β decreases the elastic modulus of human tenocytes.J Appl Physiol 101(1):189-95, 2006. 
        20. Qi J, Chi L, Wang J, Sumanasinghe R, Wall M, Tsuzaki M, Banes AJ. Modulation of collagen gel compaction by extracellular ATP is MAPK and NF-κB pathways dependent. Exp Cell Res 315(11):1990-2000, 2009. Epub 2009 Feb 23. 
        21. Rathbone SR, Glossop JR, Gough JE, Cartmell SH. Cyclic tensile strain upon human mesenchymal stem cells in 2D and 3D culture differentially influences CCNL2, WDR61 and BAHCC1 gene expression levels. J Mech Behav Biomed Mater 11:82-91, 2012. Epub 2012 Feb 3. 
        22. Sumanasinghe RD, Bernacki SH, Loboa EG. Osteogenic differentiation of human mesenchymal stem cells in collagen matrices: effect of uniaxial cyclic tensile strain on bone morphogenetic protein (BMP-2) mRNA expression. Tissue Eng 12(12):3459-3465, 2006. 
        23. Taylor SE, Vaughan-Thomas A, Clements DN, Pinchbeck G, Macrory LC, Smith RK, Clegg PD. Gene expression markers of tendon fibroblasts in normal and diseased tissue compared to monolayer and three dimensional culture systems. BMC Musculoskelet Disord10:27, 2009. 
        24. Tobita K, Liu LJ, Janczewski AM, Tinney JP, Nonemaker JM, Augustine S, Stolz DB, Shroff SG, Keller BB. Engineered early embryonic cardiac tissue retains proliferative and contractile properties of developing embryonic myocardium. Am J Physiol Heart Circ Physiol 291(4):H1829-37, 2006. 
        25. Triantafillopoulos IK, Banes AJ, Bowman KF Jr, Maloney M, Garrett WE Jr, Karas SG. Nandrolone decanoate and load increase remodeling and strength in human supraspinatus bioartificial tendons. Am J Sports Med 32(4):934-943, 2004. 
        26. Tulloch NL, Muskheli V, Razumova MV, Korte FS, Regnier M, Hauch KD, Pabon L, Reinecke H, Murry CE. Growth of engineered human myocardium with mechanical loading and vascular coculture. Circ Res 109(1):47-59, 2011. Epub 2011 May 19. 
        27. Wen W, Chau E, Jackson-Boeters L, Elliott C, Daley TD, Hamilton DW. TGF-1 and FAK regulate periostin expression in PDL fibroblasts. J Dent Res 89(12):1439-1443, 2010. Epub 2010 Oct 12.

        張力系統應變分布(TENSION SYSTEM STRAIN PROFILES)細胞牽張拉伸應力應用文獻

        1. Brown TD, Bottlang M, Pedersen DR, Banes AJ. Development and experimental validation of a fluid/structure-interaction finite element model of a vacuum-driven cell culture mechanostimulus system. Comput Methods Biomech Biomed Engin 3(1):65-78, 2000. 
        2. Brown TD, Bottlang M, Pedersen DR, Banes AJ. Loading paradigms--intentional and unintentional--for cell culture mechanostimulus. Am J Med Sci 316(3):162-168, 1998. 
        3. Colombo A, Cahill PA, Lally C. An analysis of the strain field in biaxial Flexcell membranes for different waveforms and frequencies. Proc Inst Mech Eng H 222(8):1235-1245, 2008. 
        4. Gilbert JA, Weinhold PS, Banes AJ, Link GW, Jones GL. Strain profiles for circular cell culture plates containing flexible surfaces employed to mechanically deform cells in vitro. Journal of Biomechanics 27(9):1169-1177, 1994. 
        5. Matheson LA, Jack FN, Maksym GN, Paul SJ, Labow RS. Characterization of the Flexcell Uniflex cyclic strain culture system with U937 macrophage-like cells. Biomaterials 27(2):226-233, 2006. 
        6. Throm Quinlan AM, Sierad LN, Capulli AK, Firstenberg LE, Billiar KL. Combining dynamic stretch and tunable stiffness to probe cell mechanobiology in vitro. PLoS ONE 6(8): e23272, 2011. doi:10.1371/journal.pone.0023272. 
        7. Vande Geest JP, Di Martino ES, Vorp DA. An analysis of the complete strain field within FlexercellTM membranes. Journal of Biomechanics 37:1923-1928, 2004.

        張力系統中的應用(APPLICATION OF TENSION SYSTEM)細胞牽張拉伸應力應用文獻

        1. Bartalena G, Grieder R, Sharma RI, Zambelli T, Muff R, Snedeker JG. A novel method for assessing adherent single-cell stiffness in tension: design and testing of a substrate-based live cell functional imaging device. Biomed Microdevices 13(2):291-301, 2011. 
        2. Wiggins MJ, Anderson JM, Hiltner A. Biodegradation of polyurethane under fatigue loading. J Biomed Mater Res A 65(4):524-535, 2003. 
        3. Wiggins MJ, MacEwan M, Anderson JM, Hiltner A. Effect of soft-segment chemistry on polyurethane biostability during in vitro fatigue loading. J Biomed Mater Res A 68(4):668-683, 2004.

        BIOPRESS和壓縮系統(BIOPRESS AND COMPRESSION SYSTEM)細胞壓縮系統應用文獻

        1. Bougault C, Aubert-Foucher E, Paumier A, Perrier-Groult E, Huot L, Hot D, Duterque-Coquillaud M, Mallein-Gerin F.Dynamic compression of chondrocyte-agarose constructs reveals new candidate mechanosensitive genes. PLoS One 7(5):e36964, 2012. Epub 2012 May 17.
        2. Bougault C, Paumier A, Aubert-Foucher E, Mallein-Gerin F. Molecular analysis of chondrocytes cultured in agarose in response to dynamic compression. BMC Biotechnol 8:71, 2008.
        3. Fermor B, Haribabu B, Weinberg JB, Pisetsky, Guilak F. Mechanical stress and nitric oxide influence leukotriene production in cartilage. Biochemical and Biophysical Research Communications 285:806–810, 2001.
        4. Fermor B, Weinberg JB, Pisetsky DS, Guilak F. The influence of oxygen tension on the induction of the nitric oxide and prostaglandin E2 by mechanical stress in articular cartilage. Osteoarthritis Cartilage 13:935-941, 2005.
        5. Fermor B, Weinberg JB, Pisetsky DS, Misukonis MA, Banes AJ, Guilak F. The effects of static and intermittent compression on nitric oxide production in articular cartilage explants. J Orthop Res 9(4):729-737, 2001.
        6. Fermor B, Weinberg JB, Pisetsky DS, Misukonis MA, Fink C, Guilak F. Induction of cyclooxygenase-2 by mechanical stress through a nitric oxide-regulated pathway. Osteoarthritis Cartilage 10:792–798, 2002.
        7. Fink C, Fermor B, Weinberg JB, Pisetsky DS, Misukonis MA, Guilak F. The effect of dynamic mechanical compression on nitric oxide production in the meniscus. Osteoarthritis Cartilage 9(5):481-487, 2001.
        8. Fox DB, Cook JL, Kuroki K, Cockrell M. Effects of dynamic compressive load on collagen-based scaffolds seeded with fibroblast-like synoviocytes. Tissue Eng 12(6):1527-1537, 2006.
        9. Gosset M, Berenbaum F, Levy A, Pigenet A, Thirion S, Saffar JL, Jacques C. Prostaglandin E2 synthesis in cartilage explants under compression: mPGES-1 is a mechanosensitive gene. Arthritis Research & Therapy 8:R135, 2006.
        10. Graff RD, Lazarowski ER, Banes AJ, Lee GM. ATP release by mechanically loaded porcine chondrons in pellet culture. Arthritis Rheum 43(7):1571-1579, 2000.
        11. Hennerbichler A, Fermor B, Hennerbichler, Weinberg JB, Guilak F. Regional differences in prostaglandin E2 and nitric oxide production in the knee meniscus in response to dynamic compression. Biochemical and Biophysical Research Communications358:1047–1053, 2007.
        12. Kuroki K, Cook JL, Stoker AM, Turnquist SE, Kreeger JM, Tomlinson JL. Characterizing osteochondrosis in the dog: potential roles for matrix metalloproteinases and mechanical load in pathogenesis and disease progression. Osteoarthritis Cartilage 13:225-234, 2005.
        13. Lee CY, Hsu HC, Zhang X, Wang DY, Luo ZP. Cyclic compression and tension regulate differently the metabolism of chondrocytes. J Musculoskeletal Res 9(2):59-64, 2005.
        14. Li X, Dong J, Liu C,Wang X, An M, Chen W. Contributions of intermittent cyclic compression to proteoglycans synthesis and mechanical properties of knee articular

        cartilaginous tissue formed in vitro. Biomedical Engineering and Informatics (BMEI), 2010 3rd International Conference 4:1655-1658, 2010.

        1. Maxson S, Orr D, Burg K. Bioreactors for tissue engineering. Tissue Eng 179-197, 2011.
        2. Miki Y, Teramura T, Tomiyama T, Onodera Y, Matsuoka T, Fukuda K, Hamanishi C. Hyaluronan reversed proteoglycan synthesis inhibited by mechanical stress: possible involvement of antioxidant effect. Inflamm Res 59(6):471-477, 2010. Epub 2009 Dec 15.
        3. Piscoya JL, Fermor B, Kraus VB, Stabler TV, Guilak F. The influence of mechanical compression on the induction of osteoarthritis-related biomarkers in articular cartilage explants. Osteoarthritis Cartilage 13:1092-1099, 2005.
        4. Sanchez C, Gabay O, Salvat C, Henrotin YE, Berenbaum F. Mechanical loading highly increases IL-6 production and decreases OPG expression by osteoblasts. Osteoarthritis Cartilage 17(4):473-481, 2009. Epub 2008 Oct 29.
        5. Sharma R, Vinjamaram S, Shah VA, Gupta SK, Chalam KV. The effect of elevated atmospheric pressure on the survival of retinal ganglion cells using Flexcell biopress system. Invest Ophthalmol Vis Sci 44:E-Abstract 152, 2003.
        6. Shin SJ, Fermor B, Weinberg JB, Pisetsky DS, Guilak F. Regulation of matrix turnover in meniscal explants: role of mechanical stress, interleukin-1, and nitric oxide. J Appl Physiol 95(1):308-313, 2003.
        7. Tomiyama T, Fukuda K, Yamazaki K, Hashimoto K, Ueda H, Mori S, Hamanishi C. Cyclic compression loaded on cartilage explants enhances the production of reactive oxygen species. J Rheumatol 34(3):556-562, 2007. Epub 2007 Feb 15.
        8. Upton ML, Chen J, Guilak F, Setton LA. Differential effects of static and dynamic compression on meniscal cell gene expression. J Orthop Res 21(6):963-969, 2003.
        9. Werkmeister E, de Isla N, Netter P, Stoltz JF, Dumas D. Collagenous extracellular matrix of cartilage submitted to mechanical forces studied by second harmonic generation microscopy. Photochem Photobiol 86(2):302-310, 2010. Epub 2009 Nov 18.

        壓縮系統中的應用(APPLICATION OF COMPRESSION SYSTEM)細胞壓縮系統中的應用文獻

        1. Lee CY, Hsu HC, Zhang X, Wang DY, Luo ZP. Cyclic compression and tension regulate differently the metabolism of chondrocytes. J Musculoskeletal Res 9(2):59-64, 2005. 
        2. Ackermann P, Schizas N, Bring D, Li J, Andersson T, Fahlgren A, Aspenberg P. Compression therapy promotes tissue repair and biomechanical properties during immobilization. J Bone Joint Surg Br 94B (Supp XXXVII) 89, 2012.

        FLEXFLOW流光®流體剪切力系統(FLEXFLOW AND STREAMER®FLUID SHEAR STRESS SYSTEMS)細胞流體剪切力系統應用文獻

        1. Archambault JM, Elfervig MK, Tsuzaki M, Herzog W, Banes AJ. Shear stress response of rabbit tendon cells is serum dependent.Proceedings of the Eleventh Canadian Society for Biomechanics Conference, 181, 2000. 
        2. Archambault JM, Elfervig-Wall MK, Tsuzaki M, Herzog W, Banes AJ. Rabbit tendon cells produce MMP-3 in response to fluid flow without significant calcium transients. J Biomech 35(3):303-309, 2002. 
        3. Clark PR, Jensen TJ, Kluger MS, Morelock M, Hanidu A, Qi Z, Tatake RJ, Pober JS. MEK5 is activated by shear stress, activates ERK5 and induces KLF4 to modulate TNF responses in human dermal microvascular endothelial cells. Microcirculation 18(2):102-117, 2011. doi: 10.1111/j.1549-8719.2010.00071.x. 
        4. Eifler RL, Blough ER, Dehlin JM, Haut Donahue TL. Oscillatory fluid flow regulates glycosaminoglycan production via an intracellular calcium pathway in meniscal cells. J Orthop Res 24(3):375-384, 2006. 
        5. Elfervig M, Francke E, Archambault J, Herzog W, Tsuzaki M, Bynum D, Brown TD, Banes AJ. Fluid-induced shear stress activates human tendon cells to signal through multiple Ca2+ dependent pathways [abstract]. Transactions of the 46th Annual Meeting of the Orthopaedic Research Society 25:179, 2000. 
        6. Elfervig M, Lotano M, Tsuzaki M, Faber J, Banes A J. Fluid-induced shear stress modulates Cx-43 expression in avian tendon cells but does not induce a Ca2+ signal [abstract]. Transactions of the 47th Annual Meeting of the Orthopaedic Research Society 26:570, 2001. 
        7. Elfervig MK, Minchew JT, Francke E, Tsuzaki M, Banes AJ. IL-1β sensitizes intervertebral disc annulus cells to fluid-induced shear stress. J Cell Biochem 82(2):290-298, 2001. 
        8. Finley MJ, Rauova L, Alferiev IS, Weisel JW, Levy RJ, Stachelek SJ. Diminished adhesion and activation of platelets and neutrophils with CD47 functionalized blood contacting surfaces. Biomaterials 33(24):5803-5811, 2012. Epub 2012 May 20. 
        9. Francke E, Banes A, Elfervig M, Brown T, Bynum D. Fluid-induced shear stress increases [Ca2+]ic in cultured human tendon epitenon cells [abstract]. Transactions of the 46th Annual Meeting of the Orthopaedic Research Society 25:638, 2000. 
        10. Francke E, Elfervig MK, Sood A, Brown TD, Bynum DK, Banes AJ. Fluid-induced shear stress stimulates Ca2+ signaling in human epitenon cells [abstract]. 1999 Advances in Bioengineering, J.S. Wayne, ed. American Society of Mechanical Engineers: New York, 1999. 
        11. Gao X, Wu L, O’Neil RG. Temperature-modulated diversity of TRPV4 channel gating: activation by physical stresses and phorbol ester derivatives through protein kinase C-dependent and -independent pathways. J Biol Chem 278(29):27129-27137, 2003. 
        12. Glossop JR, Hidalgo-Bastida LA, Cartmell SH. Fluid shear stress induces differential gene expression of leukemia inhibitory factor in human mesenchymal stem cells. J Biomat Tiss Eng 1:166-176, 2011. 
        13. Hosoya T, Maruyama A, Kang MI, Kawatani Y, Shibata T, Uchida K, Warabi E, Noguchi N, Itoh K, Yamamoto M. Differential responses of the Nrf2-Keap1 system to laminar and oscillatory shear stresses in endothelial cells. J Biol Chem 280(29):27244-27250, 2005. 
        14. Jaitovich A, Mehta S, Na N, Ciechanover A, Goldman RD, Ridge KM. Ubiquitin-proteasome-mediated degradation of keratin intermediate filaments in mechanically stimulated A549 cells. J Biol Chem 283(37):25348-25355, 2008. Epub 2008 Jul 10. 
        15. Kamel MA, Picconi JL, Lara-Castillo N, Johnson ML. Activation of β-catenin signaling in MLO-Y4 osteocytic cells versus 2T3 osteoblastic cells by fluid flow shear stress and PGE2: Implications for the study of mechanosensation in bone. Bone 47(5):872-881, 2010. Epub 2010 Aug 14. 
        16. Malone AM, Batra NN, Shivaram G, Kwon RY, You L, Kim CH, Rodriguez J, Jair K, Jacobs CR. The role of actin cytoskeleton in oscillatory fluid flow-induced signaling in MC3T3-E1 osteoblasts. Am J Physiol Cell Physiol 292(5):C1830-C1836, 2007. Epub 2007 Jan 24. 
        17. Metaxa E, Meng H, Kaluvala SR, Szymanski MP, Paluch RA, Kolega J. Nitric oxide-dependent stimulation of endothelial cell proliferation by sustained high flow. Am J Physiol Heart Circ Physiol 295(2):H736-H742, 2008. Epub 2008 Jun 13. 
        18. Ni J, Waldman A, Khachigian LM. c-Jun regulates shear- and injury-inducible Egr-1 expression, vein graft stenosis after autologous end-to-side transplantation in rabbits, and intimal hyperplasia in human saphenous veins. J Biol Chem 285(6):4038-4048, 2010. Epub 2009 Nov 23. 
        19. Qi J, Chi L, Faber J, Koller B, Banes AJ. ATP reduces gel compaction in osteoblast-populated collagen gels. J Appl Physiol102(3):1152-60, 2007. 
        20. Radel C, Carlile-Klusacek M, Rizzo V. Participation of caveolae in β1 integrin-mediated mechanotransduction. Biochem Biophys Res Commun 358(2):626-631, 2007. Epub 2007 May 7. 
        21. Radel C, Rizzo V. Integrin mechanotransduction stimulates caveolin-1 phosphorylation and recruitment of Csk to mediate actin reorganization. Am J Physiol Heart Circ Physiol 288(2):H936-H945, 2005. 
        22. Ridge KM, Linz L, Flitney FW, Kuczmarski ER, Chou YH, Omary MB, Sznajder JI, Goldman RD. Keratin 8 phosphorylation by protein kinase C delta regulates shear stress-mediated disassembly of keratin intermediate filaments in alveolar epithelial cells. J Biol Chem 280(34):30400-30405, 2005. 
        23. Rosser J, Bonewald LF. Studying osteocyte function using the cell lines MLO-Y4 and MLO-A5. Methods Mol Biol 816:67-81, 2012. 
        24. Sivaramakrishnan S, DeGiulio JV, Lorand L, Goldman RD, Ridge KM. Micromechanical properties of keratin intermediate filament networks. PNAS 105(3):889–894, 2008. 
        25. Sivaramakrishnan S, Schneider JL, Sitikov A, Goldman RD, Ridge KM. Shear stress induced reorganization of the keratin intermediate filament network requires phosphorylation by protein kinase C zeta. Mol Biol Cell 20(11):2755-2765, 2009. Epub 2009 Apr 8. 
        26. Srivastava T, McCarthy ET, Sharma R, Cudmore PA, Sharma M, Johnson ML, Bonewald LF. Prostaglandin E(2) is crucial in the response of podocytes to fluid flow shear stress. J Cell Commun Signal 4(2):79-90, 2010. Epub 2010 Apr 8. 
        27. Stachelek SJ, Alferiev I, Connolly JM, Sacks M, Hebbel RP, Bianco R, Levy RJ. Cholesterol-modified polyurethane valve cusps demonstrate blood outgrowth endothelial cell adhesion post-seeding in vitro and in vivo. Ann Thorac Surg 81(1):47-55, 2006.
        28. Sun HB, Liu Y, Qian L, Yokota H. Model-based analysis of matrix metalloproteinase expression under mechanical shear. Ann Biomed Eng 31(2):171-180, 2003. 
        29. Takai E, Landesberg R, Katz RW, Hung CT, Guo XE. Substrate modulation of osteoblast adhesion strength, focal adhesion kinase activation, and responsiveness to mechanical stimuli. Mol Cell Biomech 3(1):1-12, 2006. 
        30. Wang XL, Fu A, Spiro C, Lee HC. Proteomic analysis of vascular endothelial cells-effects of laminar shear stress and high glucose. J Proteomics Bioinform 2:445, 2009. 
        31. Wang P, Zhu F, Lee NH, Konstantopoulos K. Shear-induced interleukin-6 synthesis in chondrocytes: roles of E prostanoid (EP) 2 and EP3 in cAMP/protein kinase A- and PI3-K/Akt-dependent NF-kappaB activation. J Biol Chem 285(32):24793-24804, 2010. Epub 2010 Jun 1. 
        32.Wu L, Gao X, Brown RC, Heller S, O’Neil RG. Dual role of the TRPV4 channel as a sensor of flow and osmolality in renal epithelial cells. Am J Physiol Renal Physiol 293(5):F1699-F1713, 2007. Epub 2007 Aug 15. 
        33. Yang W, Lu Y, Kalajzic I, Guo D, Harris MA, Gluhak-Heinrich J, Kotha S, Bonewald LF, Feng JQ, Rowe DW, Turner CH, Robling AG, Harris SE. Dentin matrix protein 1 gene cis-regulation: use in osteocytes to characterize local responses to mechanical loading in vitro and in vivo. J Biol Chem 280(21):20680-20690, 2005. 
        34. Yokota H, Goldring MB, Sun HB. CITED2-mediated regulation of MMP-1 and MMP-13 in human chondrocytes under flow shear. J Biol Chem 278(47):47275-47280, 2003. 
        35. Yoo PS, Mulkeen AL, Dardik A, Cha CH. A novel in vitro model of lymphatic metastasis from colorectal cancer. J Surg Res143(1):94-98, 2007. Epub 2007 Jul 19. 
        36. Zhang K, Barragan-Adjemian C, Ye L, Kotha S, Dallas M, Lu Y, Zhao S, Harris M, Harris SE, Feng JQ, Bonewald LF.E11/gp38 selective expression in osteocytes: regulation by mechanical strain and role in dendrite elongation. Mol Cell Biol 26(12):4539-45, 2006. 
        37. Zhu F, Wang P, Kontrogianni-Konstantopoulos A, Konstantopoulos K. Prostaglandin (PG)D(2) and 15-deoxy-Delta(12,14)-PGJ(2), but not PGE(2), mediate shear-induced chondrocyte apoptosis via protein kinase A-dependent regulation of polo-like kinases. Cell Death Differ 17(8):1325-1334, 2010. Epub 2010 Feb 12. 
        38. Zhu F, Wang P, Lee NH, Goldring MB, Konstantopoulos K. Prolonged application of high fluid shear to chondrocytes recapitulates gene expression profiles associated with osteoarthritis. PLoS One 5(12):e15174, 2010.

        培養板和載玻片中的應用(APPLICATION OF CULTURE PLATES AND SLIDES)細胞牽張拉伸應力應用文獻

        1. Ahmed SM, Rzigalinski BA, Willoughby KA, Sitterding HA, Ellis EF. Stretch-induced injury alters mitochondrial membrane potential and cellular ATP in cultured astrocytes and neurons. J Neurochem 74(5):1951-1960, 2000. 
        2. Ahmed SM, Weber JT, Liang S, Willoughby KA, Sitterding HA, Rzigalinski BA, Ellis EF NMDA receptor activation contributes to a portion of the decreased mitochondrial membrane potential and elevated intracellular free calcium in strain-injured neurons.Journal of Neurotrauma 19(12):1619-1629, 2002. 
        3. Alenghat FJ, Tytell JD, Thodeti CK, Derrien A, Ingber DE. Mechanical control of cAMP signaling through integrins is mediated by the heterotrimeric Gαs protein. J Cell Biochem 106(4):529-538, 2009. 
        4. Arold SP, Bartolák-Suki E, Suki B. Variable stretch pattern enhances surfactant secretion in alveolar type II cells in culture.Am J Physiol Lung Cell Mol Physiol 296(4):L574-581, 2009. Epub 2009 Jan 9. 
        5. Arold SP, Wong JY, Suki B. Design of a new stretching apparatus and the effects of cyclic strain and substratum on mouse lung epithelial-12 cells. Ann Biomed Eng 35(7):1156-1164, 2007. Epub 2007 Feb 16. 
        6. Belete HA, Godin LM, Stroetz RW, Hubmayr RD. Experimental models to study cell wounding and repair. Cell Physiol Biochem25(1):71-80, 2010. Epub 2009 Dec 22. 
        7. Bell JD, Ai J, Chen Y, Baker AJ. Mild in vitro trauma induces rapid Glur2 endocytosis, robustly augments calcium permeability and enhances susceptibility to secondary excitotoxic insult in cultured Purkinje cells. Brain 130(Pt 10):2528-2542, 2007. Epub 2007 Jul 29. 
        8. Bonacci JV, Harris T, Wilson JW, Stewart AG. Collagen-induced resistance to glucocorticoid anti-mitogenic actions: a potential explanation of smooth muscle hyperplasia in the asthmatic remodelled airway. British Journal of Pharmacology 138(7):1203-1206, 2003. 
        9. Bonacci JV, Schuliga M, Harris T, Stewart AG. Collagen impairs glucocorticoid actions in airway smooth muscle through integrin signalling. Br J Pharmacol 149(4):365-373, 2006. 
        10. Boudreault F, Tschumperlin DJ. Stretch-induced mitogen-activated protein kinase activation in lung fibroblasts is independent of receptor tyrosine kinases. Am J Respir Cell Mol Biol 43(1):64-73, 2010. Epub 2009 Aug 14. 
        11. Chen SC, Wang BW, Wang DL, Shyu KG. Hypoxia induces discoidin domain receptor-2 expression via the p38 pathway in vascular smooth muscle cells to increase their migration. Biochem Biophys Res Commun 374(4):662-667, 2008. Epub 2008 Jul 26. 
        12. Chen T, Willoughby KA, Ellis EF. Group I metabotropic receptor antagonism blocks depletion of calcium stores and reduces potentiated capacitative calcium entry in strain-injured neurons and astrocytes. Journal of Neurotrauma 21(3):271-281, 2004. 
        13. Collins NT, Cummins PM, Colgan OC, Ferguson G, Birney YA, Murphy RP, Meade G, Cahill PA. Cyclic strain–mediated regulation of vascular endothelial occludin and ZO-1. Influence on intercellular tight junction assembly and function. Arterioscler Thromb Vasc Biol 26:62-68, 2006 
        14. Dunn I, Pugin J. Mechanical ventilation of various human lung cells in vitro: identification of the macrophage as the main producer of inflammatory mediators. Chest 116(1 Suppl):95S-97S, 1999. 
        15. Ellis EF, Willoughby KA, Sparks SA, Chen T. S100B protein is released from rat neonatal neurons, astrocytes, and microglia by in vitro trauma and anti-S100 increases trauma-induced delayed neuronal injury and negates the protective effect of exogenous S100B on neurons. J Neurochem 101(6):1463-1470, 2007. Epub 2007 Apr 2. 
        16. Endlich N, Kress KR, Reiser J, Uttenweiler D, Kriz W, Mundel P, Endlich K. Podocytes respond to mechanical stress in vitro. J Am Soc Nephrol 12(3):413-22, 2001. 
        17. Endlich N, Sunohara M, Nietfeld W, Wolski EW, Schiwek D, Krnzlin B, Gretz N, Kriz W, Eickhoff H, Endlich K. Analysis of differential gene expression in stretched podocytes: osteopontin enhances adaptation of podocytes to mechanical stress. FASEB J16(13):1850-1852, 2002. Epub 2002 Sep 19. 
        18. Floyd CL, Gorin FA, Lyeth BG. Mechanical strain injury increases intracellular sodium and reverses Na+/Ca2+ exchange in cortical astrocytes. Glia 51(1):35-46, 2005. 
        19. Floyd CL, Rzigalinski BA, Sitterding HA, Willoughby KA, Ellis EF. Antagonism of group I metabotropic glutamate receptors and PLC attenuates increases in inositol trisphosphate and reduces reactive gliosis in strain-injured astrocytes. Journal of Neurotrauma21(2):205-216, 2004. 
        20. Floyd CL, Rzigalinski BA, Weber JT, Sitterding HA, Willoughby KA, Ellis EF. Traumatic injury of cultured astrocytes alters inositol (1,4,5)-trisphosphate-mediated signaling. Glia 33(1):12-23, 2001. 
        21. Fudge D, Russell D, Beriault D, Moore W, Lane EB, Vogl AW. The intermediate filament network in cultured human keratinocytes is remarkably extensible and resilient. PLoS One 3(6):e2327, 2008. 
        22. Gavara N, Roca-Cusachs P, Sunyer R, Farré R, Navajas D. Mapping cell-matrix stresses during stretch reveals inelastic reorganization of the cytoskeleton. Biophys J 95(1):464-471, 2008. Epub 2008 Mar 21. 
        23. Goforth PB, Ellis EF, Satin LS. Enhancement of AMPA-mediated current after traumatic injury in cortical neurons. J Neurosci19(17):7367-7374, 1999. 
        24. Goforth PB, Ellis EF, Satin LS. Mechanical injury modulates AMPA receptor kinetics via an NMDA receptor-dependent pathway.Journal of Neurotrauma 21(6):719-732, 2004. 
        25. Hampton C, Webster GD, Rzigalinski B, Gabler HC. Mechanical properties of polytetraflouroethylene elastomer membrane for dynamic cell culture testing. Biomed Sci Instrum 44:105-110, 2008. 
        26. Hasel C, Durr S, Bauer A, Heydrich R, Bruderlein S, Tambi T, Bhanot U, Moller P. Pathologically elevated cyclic hydrostatic pressure induces CD95-mediated apoptotic cell death in vascular endothelial cells. Am J Physiol Cell Physiol 289(2):C312-C322, 2005. 
        27. Kao CQ, Goforth PB, Ellis EF, Satin LS. Potentiation of GABA(A) currents after mechanical injury of cortical neurons. Journal of Neurotrauma 21(3):259-270, 2004. 
        28. Kito H, Chen EL, Wang X, Ikeda M, Azuma N, Nakajima N, Gahtan V, Sumpio BE. Role of mitogen-activated protein kinases in pulmonary endothelial cells exposed to cyclic strain. J Appl Physiol 89(6):2391-2400, 2000. 
        29. Kizer N, Guo XL, Hruska K. Reconstitution of stretch-activated cation channels by expression of the α-subunit of the epithelial sodium channel cloned from osteoblasts Proc Natl Acad Sci U S A 94(3):1013-1018, 1997. 
        30. Krüger M, Sachse C, Zimmermann WH, Eschenhagen T, Klede S, Linke WA. Thyroid hormone regulates developmental titin isoform transitions via the phosphatidylinositol-3-kinase/ AKT pathway. Circ Res 102(4):439-447, 2008. Epub 2007 Dec 20. 
        31. Kuznetsov SA, Mankani MH, Gronthos S, Satomura K, Bianco P, Robey PG. Circulating skeletal stem cells J Cell Biol153(5):1133-1140, 2001. 
        32. Lamb RG, Harper CC, McKinney JS, Rzigalinski BA, Ellis EF. Alterations in phosphatidylcholine metabolism of stretch-injured cultured rat astrocytes. J Neurochem 68(5):1904-1910, 1997. 
        33. Lapanantasin S, Chongthammakun S, Floyd CL, Berman RF. Effects of 17β-estradiol on intracellular calcium changes and neuronal survival after mechanical strain injury in neuronal-glial cultures. Synapse 60(5):406-410, 2006. 
        34. Lea PM, Custer SJ, Stoica BA, Faden AI. Modulation of stretch-induced enhancement of neuronal NMDA receptor current by mGluR1 depends upon presence of glia. Journal of Neurotrauma 20(11):1233-1249, 2003. 
        35. Lea PM, Custer SJ, Vicini S, Faden AI. Neuronal and glial mGluR5 modulation prevents stretch-induced enhancement of NMDA receptor current. Pharmacology Biochemistry and Behavior 73(2):287-298, 2002. 
        36. Lehnich H, Simm A, Weber B, Bartling B. Development of a cyclic multi-axial strain cell culture device. Biomed Tech (Berl),2012. pii: /j/bmte.2012.57.issue-s1-G/bmt-2012-4182/bmt-2012-4182.xml. doi: 10.1515/bmt-2012-4182. [Epub ahead of print] 
        37. Lewko B, Bryl E, Witkowski JM, Latawiec E, Angielski S, Stepinski J. Mechanical stress and glucose concentration modulate glucose transport in cultured rat podocytes. Nephrol Dial Transplant 20(2):306-311, 2005. 
        38. Lewko B, Endlich N, Kriz W, Stepinski J, Endlich K. C-type natriuretic peptide as a podocyte hormone and modulation of its cGMP production by glucose and mechanical stress. Kidney International 66(3):1001-1008, 2004. 
        39. Liebau MC, Lang D, Bohm J, Endlich N, Bek MJ, Witherden I, Mathieson PW, Saleem MA, Pavenstadt H, Fischer KG. Functional expression of the renin-angiotensin system in human podocytes. Am J Physiol Renal Physiol 290(3):F710-F719, 2006. 
        40. Maul TM, Hamilton DW, Nieponice A, Soletti L, Vorp DA. A new experimental system for the extended application of cyclic hydrostatic pressure to cell culture. J Biomech Eng 129(1):110-6, 2007. 
        41. McKinney JS, Willoughby KA, Liang S, Ellis EF. Stretch-induced injury of cultured neuronal, glial, and endothelial cells. Effect of polyethylene glycol-conjugated superoxide dismutase. Stroke 27(5):934-940, 1996. 
        42. Neary JT, Kang Y, Tran M, Feld J. Traumatic injury activates protein kinase B/Akt in cultured astrocytes: role of extracellular ATP and P2 purinergic receptors. Journal of Neurotrauma 22(4):491-500, 2005. 
        43. Neary JT, Kang Y, Willoughby KA, Ellis EF. Activation of extracellular signal-regulated kinase by stretch-induced injury in astrocytes involves extracellular ATP and P2 purinergic receptors. J Neurosci 23(6):2348-2356, 2003. 
        44. Onodera K, Takahashi I, Sasano Y, Bae JW, Mitani H, Kagayama M, Mitani H. Stepwise mechanical stretching inhibits chondrogenesis through cell-matrix adhesion mediated by integrins in embryonic rat limb-bud mesenchymal cells. European Journal of Cell Biology 84(1):45-58, 2005. 
        45. Pugin J, Dunn I, Jolliet P, Tassaux D, Magnenat JL, Nicod LP, Chevrolet JC. Activation of human macrophages by mechanical ventilation in vitro. Am J Physiol Lung Cell Mol Physiol 275:L1040-L1050, 1998. 
        46. Putnam AJ, Cunningham JJ, Pillemer BBL, Mooney DJ. External mechanical strain regulates membrane targeting of Rho GTPases by controlling microtubule assembly. Am J Physiol Cell Physiol 284(3):C627-C639, 2003. 
        47. Putnam AJ, Schultz K, Mooney DJ. Control of microtubule assembly by extracellular matrix and externally applied strain Am J Physiol Cell Physiol 280(3):C556-C564, 2001. 
        48. Quaglino A, Salierno M, Pellegrotti J, Rubinstein N, Kordon EC. Mechanical strain induces involution-associated events in mammary epithelial cells. BMC Cell Biol 10:55, 2009. 
        49. Rana OR, Zobel C, Saygili E, Brixius K, Gramley F, Schimpf T, Mischke K, Frechen D, Knackstedt C, Schwinger RH, Schauerte P, Saygili E. A simple device to apply equibiaxial strain to cells cultured on flexible membranes. Am J Physiol Heart Circ Physiol 294(1):H532-540, 2008. Epub 2007 Oct 26. 
        50. Rauch C, Loughna PT. Cyclosporin-A inhibits stretch-induced changes in myosin heavy chain expression in C2C12 skeletal muscle cells. Cell Biochem Funct 24(1):55-61, 2006. 
        51. Rauch C, Loughna PT. Static stretch promotes MEF2A nuclear translocation and expression of neonatal myosin heavy chain in C2C12 myocytes in a calcineurin- and p38-dependent manner. Am J Physiol Cell Physiol 288(3):C593-C605, 2005. 
        52. Reimann S, Rath-Deschner B, Deschner J, Keilig L, Jger A, Bourauel C. Development of an experimental device for the application of static and dynamic tensile strain on cells. 4th European Conference of the International Federation for Medical and Biological Engineering 22:2019-2022, 2009. 
        53. Rzigalinski BA, Liang S, McKinney JS, Willoughby KA, Ellis EF. Effect of Ca2+ on in vitro astrocyte injury. J Neurochem68(1):289-296, 1997. 
        54. Rzigalinski BA, Weber JT, Willoughby KA, Ellis EF. Intracellular free calcium dynamics in stretch-injured astrocytes. J Neurochem 70(6):2377-2385, 1998. 
        55. Sawada Y, Suda M, Yokoyama H, Kanda T, Sakamaki T, Tanaka S, Nagai R, Abe S, Takeuchi T. Stretch-induced hypertrophic growth of cardiocytes and processing of brain-type natriuretic peptide are controlled by proprotein-processing endoprotease furin. J Biol Chem 272(33):20545-20554, 1997. 
        56. Schordan S, Schordan E, Endlich K, Endlich N. αV-integrins mediate the mechanoprotective action of osteopontin in podocytes.Am J Physiol Renal Physiol 300(1):F119-F132, 2011. Epub 2010 Nov 3. 
        57. Schordan E, Welsch S, Rothhut S, Lambert A, Barthelmebs M, Helwig JJ, Massfelder T. Role of parathyroid hormone-related protein in the regulation of stretch-induced renal vascular smooth muscle cell proliferation. J Am Soc Nephrol 15(12):3016-3025, 2004. 
        58. Slemmer JE, Matser EJ, De Zeeuw CI, Weber JT. Repeated mild injury causes cumulative damage to hippocampal cells. Brain125(Pt 12):2699-2709, 2002. 
        59. Slemmer JE, Zhu C, Landshamer S, Trabold R, Grohm J, Ardeshiri A, Wagner E, Sweeney MI, Blomgren K, Culmsee C, Weber JT, Plesnila N. Causal role of apoptosis-inducing factor for neuronal cell death following traumatic brain injury. Am J Pathol173(6):1795-1805, 2008. Epub 2008 Nov 6. 
        60. Sowa G, Agarwal S. Motion exerts a protective effect on intervertebral discs. American Journal of Physical Medicine & Rehabilitation 85(3):246-247, 2006. 
        61. Sowa G, Agarwal S. Cyclic tensile stress exerts a protective effect on intervertebral disc cells. American Journal of Physical Medicine & Rehabilitation 87(7):537-544, 2008.
        62. Stroetz RW, Vlahakis NE, Walters BJ, Schroeder MA, Hubmayr RD. Validation of a new live cell strain system: characterization of plasma membrane stress failure. J Appl Physiol 90(6):2361-2370, 2001. 
        63. Takahashi I, Onodera K, Sasano Y, Mitzoguchi I, Bae JW, Mitani H, Kagayama M, Mitani H. Effect of stretching on gene expression of β1 integrin and focal adhesion kinase and on chondrogenesis through cell-extracellular matrix interactions. European Journal of Cell Biology 82(4):182-192, 2003. 
        64. Tamada M, Sheetz MP, Sawada Y. Activation of a signaling cascade by cytoskeleton stretch. Dev Cell 7:709-718, 2004. 
        65. Tavalin SJ, Ellis EF, Satin LS. Inhibition of the electrogenic Na pump underlies delayed depolarization of cortical neurons after mechanical injury or glutamate. J Neurophysiol 77:632-638, 1997. 
        66. Tavalin SJ, Ellis EF, Satin LS. Mechanical perturbation of cultured cortical neurons reveals a stretch-induced delayed depolarization. J Neurophysiol 74(6):2767-2773, 1995. 
        67. Toyoda T, Matsumoto H, Fujikawa K, Saito S, Inoue K. Tensile load and the metabolim of anterior cruciate ligament cells.Clinical Orthopaedics & Related Research 353:247-255, 1998. 
        68. Toyoda T, Saito S, Inokuchi S, Yabe Y. The effects of tensile load on the metabolism of cultured chondrocytes. Clin Orthop Relat Res (359):221-228, 1999. 
        69. Tran MD, Neary JT. Purinergic signaling induces thrombospondin-1 expression in astrocytes. PNAS 103(24):9321–9326, 2006. 
        70. Trepat X, Deng L, An SS, Navajas D, Tschumperlin DJ, Gerthoffer WT, Butler JP, Fredberg JJ. Universal physical responses to stretch in the living cell. Nature 447(7144):592-595, 2007. 
        71. Trepat X, Grabulosa M, Puig F, Maksym GN, Navajas D, Farre R. Viscoelasticity of human alveolar epithelial cells subjected to stretch. Am J Physiol Lung Cell Mol Physiol 287(5):L1025-L1034, 2004. 
        72. Trepat X, Puig F, Gavara N, Fredberg JJ, Farre R, Navajas D. Effect of stretch on structural integrity and micromechanics of human alveolar epithelial cell monolayers exposed to thrombin. Am J Physiol Lung Cell Mol Physiol 290(6):L1104-L1110, 2006. Epub 2006 Jan 6. 
        73. Tyurina YY, Nylander KD, Mirnics ZK, Portugal C, Yan C, Zaccaro C, Saragovi HU, Kagan VE, Schor NF. The intracellular domain of p75NTR as a determinant of cellular reducing potential and response to oxidant stress. Aging Cell 4(4):187-196, 2005. 
        74. Upton ML, Chen J, Setton LA. Region-specific constitutive gene expression in the adult porcine meniscus. J Orthop Res24(7):1562-1570, 2006. 
        75. Vincent F, Duquesnes N, Christov C, Damy T, Samuel JL, Crozatier B. Dual level of interactions between calcineurin and PKC-ε in cardiomyocyte stretch. Cardiovasc Res 71(1):97-107, 2006. 
        76. Vlahakis NE, Schroeder MA, Pagano RE, Hubmayr RD. Deformation-induced lipid trafficking in alveolar epithelial cells. Am J Physiol Lung Cell Mol Physiol 280(5):L938-L946, 2001. 
        77. Wagner AH, Schroeter MR, Hecker M. 17β-estradiol inhibition of NADPH oxidase expression in human endothelial cells. FASEB J15(12):2121-2130, 2001. 
        78. Wang D, Taboas JM, Tuan RS. PTHrP overexpression partially inhibits a mechanical strain-induced arthritic phenotype in chondrocytes. Osteoarthritis Cartilage 19(2):213-221, 2011. Epub 2010 Nov 16. 
        79.Weber JT, Rzigalinski BA, Ellis EF. Calcium responses to caffeine and muscarinic receptor agonists are altered in traumatically injured neurons. Journal of Neurotrauma 19(11):1433-1443, 2002. 
        80.Weber JT, Rzigalinski BA, Ellis EF. Traumatic injury of cortical neurons causes changes in intracellular calcium stores and capacitative calcium influx. J Biol Chem 276(3):1800-1807, 2001. 
        81. Weber JT, Rzigalinski BA, Willoughby KA, Moore SF, Ellis EF. Alterations in calcium-mediated signal transduction after traumatic injury of cortical neurons. Cell Calcium 26(6):289-299, 1999. 
        82.Willoughby KA, Kleindienst A, Muller C, Chen T, Muir JK, Ellis EF. S100B protein is released by in vitro trauma and reduces delayed neuronal injury. J Neurochem 91(6):1284-1291, 2004. 
        83. Xu Q, Schett G, Li C, Hu Y, Wick G. Mechanical stress-induced heat shock protein 70 expression in vascular smooth muscle cells is regulated by Rac and Ras small G proteins but not mitogen-activated protein kinases. Circ Res 86(11):1122-1128, 2000. 
        84. Xu Z, Buckley MJ, Evans CH, Agarwal S. Cyclic tensile strain acts as an antagonist of IL-1β actions in chondrocytes. J Immunol 165(1):453-60, 2000. 
        85. Yamamoto H, Teramoto H, Uetani K, Igawa K, Shimizu E. Cyclic stretch upregulates interleukin-8 and transforming growth factor-β1 production through a protein kinase C-dependent pathway in alveolar epithelial cells. Respirology 7(2):103-109, 2002. 
        86. Yan C, Liang Y, Nylander KD, Schor NF. TrkA as a life and death receptor: receptor dose as a mediator of function. Cancer Res62:4867-4875, 2002. 
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        88. Zhan M, Jin B, Chen SE, Reecy JM, Li YP. TACE release of TNF-α mediates mechanotransduction-induced activation of p38 MAPK and myogenesis. J Cell Sci 120(Pt 4):692-701, 2007. Epub 2007 Jan 30. 
        89. Zhong C, Chrzanowska-Wodnicka M, Brown J, Shaub A, Belkin AM, Burridge K. Rho-mediated contractility exposes a cryptic site in fibronectin and induces fibronectin matrix assembly. J Cell Biol 141(12):539-551, 1998.

        客戶改性單位(CUSTOMER-MODIFIED UNITS)細胞牽張拉伸應力應用

        1. Boerboom RA, Rubbens MP, Driessen NJ, Bouten CV, Baaijens FP. Effect of strain magnitude on the tissue properties of engineered cardiovascular constructs. Annals of Biomedical Engineering 36(2):244–253, 2008. 
        2. Fermor B, Haribabu B, Weinberg JB, Pisetsky, Guilak F. Mechanical stress and nitric oxide influence leukotriene production in cartilage. Biochemical and Biophysical Research Communications 285:806–810, 2001. 
        3. Fermor B, Weinberg JB, Pisetsky DS, Guilak F. The influence of oxygen tension on the induction of the nitric oxide and prostaglandin E2 by mechanical stress in articular cartilage. Osteoarthritis Cartilage 13:935-941, 2005. 
        4. Fermor B, Weinberg JB, Pisetsky DS, Misukonis MA, Banes AJ, Guilak F. The effects of static and intermittent compression on nitric oxide production in articular cartilage explants. J Orthop Res 9(4):729-737, 2001. 
        5. Fermor B, Weinberg JB, Pisetsky DS, Misukonis MA, Fink C, Guilak F. Induction of cyclooxygenase-2 by mechanical stress through a nitric oxide-regulated pathway. Osteoarthritis Cartilage 10:792–798, 2002. 
        6. Fink C, Fermor B, Weinberg JB, Pisetsky DS, Misukonis MA, Guilak F. The effect of dynamic mechanical compression on nitric oxide production in the meniscus. Osteoarthritis Cartilage 9(5):481-487, 2001. 
        7. Fisher DD, Cyr RJ. Mechanical forces in plant growth and development. Gravit Space Biol Bull 13(2):67-73, 2000. 
        8. Giunti S, Pinach S, Arnaldi L, Viberti G, Perin PC, Camussi G, Gruden G. The MCP-1/CCR2 system has direct proinflammatory effects in human mesangial cells. Kidney Int 69(5):856-863, 2006. 
        9. Hasel C, Durr S, Bruderlein S, Melzner I, Moller P. A cell-culture system for long-term maintenance of elevated hydrostatic pressure with the option of additional tension. J Biomechanics 35(5):579-584, 2002. 
        10. Meng F, Suchyna TM, Sachs F. A fluorescence energy transfer-based mechanical stress sensor for specific proteins in situ. FEBS J 275(12):3072-3087, 2008. Epub 2008 May 10. 
        11. Park SA, Kim IA, Lee YJ, Shin JW, Kim CR, Kim JK, Yang YI, Shin JW. Biological responses of ligament fibroblasts and gene expression profiling on micropatterned silicone substrates subjected to mechanical stimuli. J Biosci Bioeng 102(5):402-412, 2006. 
        12. Piscoya JL, Fermor B, Kraus VB, Stabler TV, Guilak F. The influence of mechanical compression on the induction of osteoarthritis-related biomarkers in articular cartilage explants. Osteoarthritis Cartilage 13:1092-1099, 2005. 
        13. Rubbens MP, Driessen-Mol A, Boerboom RA, Koppert MM, van Assen HC, TerHaar Romeny BM, Baaijens FP, Bouten CV.Quantification of the temporal evolution of collagen orientation in mechanically conditioned engineered cardiovascular tissues. Ann Biomed Eng 37(7):1263-1272, 2009. Epub 2009 May 5. 
        14. Shin SJ, Fermor B, Weinberg JB, Pisetsky DS, Guilak F. Regulation of matrix turnover in meniscal explants: role of mechanical stress, interleukin-1, and nitric oxide. J Appl Physiol 95(1):308-313, 2003. 
        15. Tobita K, Garrison JB, Keller BB. Differential effects of cyclic stretch on embryonic ventricular cardiomyocyte and non-cardiomyocyte orientation. Edited by Clark EB, Nakazawa M, Takao A. Blackwell Futura Publishing:177-179, 2005.
        16. Upton ML, Chen J, Guilak F, Setton LA. Differential effects of static and dynamic compression on meniscal cell gene expression. J Orthop Res 21(6):963-969, 2003.

        美國專利(U.S. PATENTS)細胞牽張拉伸應力應用

        1. Banes AJ, Maloney MM. Method and system for measuring properties of deformable material specimens. Issued April 13, 2004. Patent No. 6,721,667. 
        2. Banes AJ. Apparatus for growing cells in culture under shear stress and/or strain. Issued July 1, 2003. Patent No. 6,586,235. 
        3. Banes AJ. Apparatus for growing cells in culture under shear stress and/or strain. Issued November 11, 2003. Patent No. 6,645,759. 
        4. Banes AJ. Culture compression device. Issued March 14, 2000. Patent No. 6,037,141. 
        5. Banes AJ. Flexible bottom culture plate for applying mechanical load to cell cultures. Issued April 11, 2000. Patent No. 6,048,723.
        6. Banes AJ. Loading station assembly and method for tissue engineering. Issued October 29, 2002. Patent No. 6,472,202. 
        7. Banes AJ. Loading station assembly. Issued April 17, 2001. Patent No. 6,218,178. 
        8. Banes AJ. Method and apparatus to grow and mechanically condition cell cultures. Issued February 14, 2006. Patent No. 6,998,265. 
        9. Bodine PV. Pharmaceutical compositions and methods of using secreted frizzled related protein. Issued August 29, 2006. Patent No. 7,098,372
        10. Hecker M, Lauth M, Wagner AH. Modulating transcription of genes in vascular cells. Issued March 6, 2007. Patent No. 7,186,556
        11. Hruska K, Wozniak M. Cell matrix plaques of initial bone formation. Issued March 30, 2004. Patent No. 6,713,249
        12. Hruska KA, Friedman PA, Barry EL, Duncan RL. Voltage-gated calcium channel and antisense oligonucleotides thereto. Issued October 20, 1998. Patent No. 5,824,550
        13. Hungerford DS, Frondoza CG, Shikani AH, Domb AJ. Cell-culture and polymer constructs. Issued October 28, 2003. Patent No. 6,637,437
        14. Sheetz MP, Sawada Y. System and method for identifying proteins involved in force-initiated signal transduction. Issued January 3, 2006. Patent No. 6,982,150
        15. Torday JS, Rehan VK. Method of inhibiting lipofibroblast to myofibroblast transdifferentiation. Issued January 31, 2006. Patent No. 6,992,093
        16. Tymianski M. Method of screening peptides useful in treating traumatic injury to the brain or spinal cord. Issued March 31, 2009.Patent No. 7,510,824.

        國際專利(INTERNATIONAL PATENTS)細胞牽張拉伸應力應用

        1. Al-Jamal R, Harrison D. Compounds and methods for the modulation of β-1 integrin function to mediate tissue repair. Published September 04, 2008. Patent No. WO/2008/104808. 
        2. Banes AJ, Qi J. Modulation of cell intrinsic strain to control cell modulus, matrix synthesis, secretion, organization, material properties and remodeling of tissue engineered constructs. Published September 22, 2005. Patent No. WO/2005/086881. 
        3. Banes AJ, Qi J. Modulation of cell intrinsic strain to control matrix synthesis, secretion, organization and remodeling. Published March 17, 2005. Patent No. WO/2005/023988. 
        4. Banes AJ. Method and apparatus to grow and mechanically condition cell cultures. Published June 13, 2002. Patent No. WO/2002/046365.
        5. Blott PLewis, Hartwell EY, Lee-Webb J, Nicolini D. Wound treatment apparatus and method. Published November 02, 2006. Patent No. WO/2006/114637. 
        6. Bodine PV. Pharmaceutical compositions and methods of using secreted frizzled related protein. Published March 22, 2001. Patent No. WO/2001/019855
        7. Hruska K, Wozniak M. Cell matrix plaques of initial bone formation. Published June 08, 2000. Patent No. WO/2000/033077.
        8. Hruska KA, Friedman PA, Barry EL, Duncan RL. Stretch-activated cation channel and antisense oligonucleotides thereto. Published May 09, 1996. Patent No. WO/1996/013269
        9. Paleck SP, De Pablo JJ, Li L. Method of reducing embryonic stem cell differentiation. Published June 09, 2005. Patent No. WO/2005/052142. 
        10. Rade JJ, Kapur NKumar. Augmentation of endothelial thromboresistance. Published September 27, 2007. Patent No. WO/2007/108992. 
        11. Roberts A, Saika S, Ooshima A. Use of SMAD3 inhibitor in the treatment of fibrosis dependent on epithelial to mesenchymal transition as in the eye and kidney. Published August 05, 2004. Patent No. WO/2004/064770. 
        12. Sheetz MP, Sawada Y. System and method for identifying proteins involved in force-initiated signal transduction. Published August 21, 2003. Patent No. WO/2003/069330. 
        13. Torday JS, Rehan VK, Mink R. Use of parathyroid hormone-related protein (PTHrP) in the diagnosis and treatment of chronic lung disease and other pathologies. Published November 13, 2003. Patent No. WO/2003/092685. 
        14. Wang G, Burczynski FJ, Anderson JE. Compositions and methods for enhancing nitric oxide delivery. Published December 14, 2006.Patent No. WO/2006/130982.

        15. Yokota H, Sun HB. Methods for predicting transcription levels. Published April 24, 2003. Patent No. WO/2003/033679. We invite our customers to submit recent publications to be posted in this listing and on our website (www.flexcellint.com).

      (來源: 世聯博研(北京)科技有限公司


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