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      現在位置首頁>實驗室服務>實驗室服務>抗體定制>Anti- Dxd (Exatecan derivative for ADC) antibody, mAbYKZP1802
      Anti- Dxd (Exatecan derivative for ADC) antibody, mAbYKZP1802
      Anti- Dxd (Exatecan derivative for ADC) antibody, mAbYKZP1802
      • Anti- Dxd (Exatecan derivative for ADC) antibody, mAbYKZP1802

      Anti- Dxd (Exatecan derivative for ADC) antibody, mAbYKZP1802

      產品報價:39800元

      更新時間:2022/4/14 14:38:38

      地:上海

      牌:友科生物

      號:YKZP1802

      廠商性質:

      公司名稱: 上海友科生物科技有限公司

      產品關鍵詞: 抗體藥物定制開發   多抗制備   多克隆抗體定制   抗體定制   多克隆抗體制備  

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      Anti- Dxd (Exatecan derivative for ADC) antibody, mAb YKZP1802

      Dxd 鼠單抗

      編號:YKZP1802

      Background
      Dxd (Exatecan derivative for ADC) is a potent DNA topoisomerase I inhibitor, with an IC50 of 0.31 μM, used as a conjugated drug of HER2-targeting ADC (DS-8201a). Dxd is cytotoxic to human cancer cell lines of KPL-4, NCI-N87, SK-BR-3, and MDA-MB-468 with IC50s of 1.43 nM-4.07 nM, but the control IgG-ADC (Dxd is the payload) shows no inhibition on the four cell lines (with HER2 expression). DS-8201a (Dxd is the payload) displays significant suppression on the HER2-positive KPL-4, NCI-N87, and SK-BR-3 cell lines, with IC50 values of 26.8, 25.4, and 6.7 ng/mL, respectively, but with no such inhibition on MDA-MB-468 (IC50, >10,000 ng/mL).

      Anti- Dxd (Exatecan derivative for ADC) antibody, mAb YKZP1802

      Monomethyl auristatin E (MMAE; SGD-1010) 是海兔毒素10的合成衍生物,通過抑制微管蛋白聚合而起到有效的有絲分裂抑制作用。MMAE廣泛用作細胞毒性成分制作抗體-藥物偶聯物 (ADCs) 以治療癌癥。

      Dxd (Exatecan derivative for ADC) is a potent inhibitor of DNA topoisomerase I (IC50: 0.31 μM). It is used as a conjugated drug of HER2-targeting ADC.

      #ADC-Ab0001 mouse monoclonal antibody can recognize Dxd and Dxd structurally similar molecules

      Concentration:

      1 mg/ml. Protein was determined by OD280 absorbance.

      Physical State:Liquid

      Reactivity:

      Dxd and Dxd structurally similar molecules

      Storage Condition:Store at -20 °C. Stable for 12 months from date of receipt.

      Anti-MMAF (Monomethyl Auristain F) antibody, mAb YKZP1802

      MMAF鼠單抗 

      Background

      Monomethyl auristatin F (MMAF) is a synthetic antineoplastic agent. It is part of the approved drug belantamab mafodotin in multiple myeloma and some experimental anti-cancer antibody-drug conjugates such as vorsetuzumab mafodotin and SGN-CD19A. In International Nonproprietary Names for MMAF-antibody-conjugates, the name mafodotin refers to MMAF plus its attachment structure to the antibody.


       Anti-MMAF (Monomethyl Auristain F) antibody, mAb

      MMAF (Monomethylauristatin F) hydrochloride 是一種有效的微管蛋白聚合 (tubulin polymerization抑制劑,用作抗腫瘤藥物。MMAF hydrochloride 廣泛用作抗體偶聯藥物 (ADCs) 的細胞毒性成分,如 Vorsetuzumab mafodotin  SGN-CD19A。

       




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